CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3279
Family Name Macrophage migration inhibitory factor Inhibitor 1-(2-chlorophenyl)-3-(pyridin-2-yl)thiourea Family
No. of Seeds 2 No. of Other Members 22
Family Centroid CFAMM00287722 Functional Category Investigative Drug
Superfamily Reverse transcriptase and Macrophage migration inhibitory factor Binder Superfamily
Class Class 88

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
Transient receptor potential cation channel subfamily V member... 16 295
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 23 63
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Carbonic anhydrase 2 Inhibitor Cyanamide Family 2 32
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Adenosine receptor A1 and Adenosine receptor A2a Ligand 3-benz... 1 6
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Transient receptor potential cation channel subfamily V member... 2 26
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 2-(4-... 8 25
Reverse transcriptase Inhibitor PT-102 Family 8 12
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Reverse transcriptase Inhibitor PT-109 Family 6 7
Metabotropic glutamate receptor 5 Ligand 5-(2-(3-chlorophenyl)... 2 13
5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor li... 2 3
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
Bloom syndrome protein inhibitor SR 57227A family 2 12
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Acetylcholine receptor subunit delta ligand Guanidine, N-[(6-c... 2 15
Histamine H4 receptor ligand 4-[(3R)-3-(methylamino)pyrrolidin... 7 6
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 10
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Acetylcholinesterase and Cholinesterase inhibitor 2-amino-6-[3... 1 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 2
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Farnesyl pyrophosphate synthase inhibitor AC1NQOV1 family 2 1
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 2 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 10 1
D(4) dopamine receptor and D(2) dopamine receptor ligand (E)-1... 1 2
Nitric oxide synthase, brain and Nitric oxide synthase, induci... 2 0
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Reverse transcriptase/RNaseH inhibitor PETT deriv. 13 family 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 2
Putative hexokinase HKDC1 inhibitor MLS002702208 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00287722 DNC011213 Investigative Drug 1-(2-chlorophenyl)-3-(pyridin-2-yl)thiourea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27256 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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