CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3288
Family Name Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-aminobutyric acid receptor subunit gamma-2 Ligand Ethyl 9h-pyrido[3,4-b]indole-3-carboxylate Family
No. of Seeds 24 No. of Other Members 64
Family Centroid CFAMM00288154 Functional Category Investigative Drug with Natural Product
Superfamily Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-aminobutyric acid receptor subunit gamma-2 Ligand Ethyl 9h-pyrido[3,4-b]indole-3-carboxylate Superfamily
Class Class 2724

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
5-hydroxytryptamine receptor 3A Ligand Dolasetron Family 12 171
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Diacylglycerol O-acyltransferase 2 and Hydroxycarboxylic acid ... 4 45
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
DNA Binder Elliptinium Acetate Family 11 116
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Histone deacetylase 1 Inhibitor MS-275 Family 4 41
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Substance-P receptor Ligand GSK424887 Family 8 184
Sodium channel Ligand GSK1014802 Family 4 92
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Lethal factor Inhibitor GM6001 Family 50 435
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
AP endonuclease APE1 Inhibitor 5-fluoro-1h-indole-2-carboxylic... 2 61
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Tyrosine-protein phosphatase non-receptor type 1 Ligand Cauler... 2 8
Lethal factor Inhibitor 3-(2,5-dimethyl-1h-pyrrol-1-yl)benzoic... 2 44
Fatty acid-binding protein, adipocyte Inhibitor 1-benzyl-2,3-d... 1 8
Egl nine homolog 2 Inhibitor Pyridine-2,4-dicarboxylic Acid Fa... 2 21
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Kinesin-like protein KIF11 Inhibitor Methyl 7-tert-butyl-9h-ca... 2 9
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand (6-ben... 2 5
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand Isoqui... 1 6
Endothelin B receptor Ligand IRL-2500 Family 34 87
Tubulin beta chain Inhibitor Isopropyl 3-(phenylthio)-1h-indol... 1 7
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 6-phenylethynyl-nicot... 2 26
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
5-hydroxytryptamine receptor 3A Ligand 3alpha-(1'-methyl-2'-in... 2 17
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
Prostaglandin E2 receptor EP4 subtype and Prostaglandin D2 rec... 8 17
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 10 4
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 5 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Neutrophil collagenase and Stromelysin-3 inhibitor AC1MORIH fa... 7 9
Sodium-dependent serotonin transporter and D(2) dopamine recep... 13 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
NS5B protein inhibitor AC1NQMYG family 6 12
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Renin inhibitor [(2S,4S,5S,7R)-4-amino-8-(butylamino)-5-hydrox... 3 1
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Retinoic acid receptor gamma and Retinoic acid receptor alpha ... 2 3
Retinoic acid receptor beta and Retinoic acid receptor alpha l... 2 2
Retinoic acid receptor alpha and Retinoic acid receptor beta l... 1 2
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 4 53
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Glutamate receptor ionotropic, NMDA 1 ligand (3S)-3-[2-[4-(ami... 2 2
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 4
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... 3 15
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Glucocorticoid receptor ligand SureCN4198717 family 5 0
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-[2-(2-h... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Scavenger receptor class B member 1 ligand methyl 9-[3-(4,6-di... 2 10
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[2-(1H-ind... 1 0
Collagenase 3 and Matrix metalloproteinase-14 inhibitor 4-[[[5... 2 4
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 3 6
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Prostaglandin D2 receptor 2 ligand 2-[1-(4-benzamidobenzoyl)is... 4 9
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Egl nine homolog 1 inhibitor 2-[5-methyl-6-[[1-oxo-2-(4-phenyl... 4 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 1
Rho-associated protein kinase 2 inhibitor 2-hydroxyethyl 3-[2-... 2 0
Neutrophil collagenase and Stromelysin-3 inhibitor [3-[[1-amin... 3 2
Gastrin/cholecystokinin type B receptor ligand (2R)-2-[[5-(8-a... 2 3
Cyclin-dependent kinase 2 and Vascular endothelial growth fact... 1 1
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(... 2 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
RAC-alpha serine/threonine-protein kinase inhibitor Isoquinoli... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
KiSS-1 receptor ligand N-[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-... 1 0
Thromboxane-A synthase inhibitor AGN-PC-00NE8C family 2 3
D-amino-acid oxidase inhibitor SureCN679780 family 1 5
Ras guanyl-releasing protein 3 and Protein kinase C alpha type... 1 2
Beta-3 adrenergic receptor ligand SureCN5704018 family 4 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 16 3
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1340977 family 1 5
Huntingtin and Alkaline phosphatase, tissue-nonspecific isozym... 1 5
TGF-beta receptor type-1 ligand Methyl 4-(4-(3-(pyridin-2-yl)-... 1 2
Bifunctional epoxide hydrolase 2 inhibitor ethyl 1-[[4-[(1-ada... 7 5
Methionine aminopeptidase 1 inhibitor ethyl 4-[4-(2-pyridin-2-... 2 3
Glycine receptor subunit alpha-1 ligand [(1R,5R)-8-azabicyclo[... 2 10
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 48
Caspase-1 inhibitor (3S)-5-[2-(1H-indol-3-yl)acetyl]oxy-4-oxo-... 1 0
Protein kinase C alpha type inhibitor methyl 4-[[4-[[2-[3-[4-(... 3 0
Serine/threonine-protein kinase pim-3 inhibitor methyl 6-amino... 1 2
Calcium/calmodulin-dependent protein kinase type II subunit de... 1 0
Transmembrane prolyl 4-hydroxylase inhibitor 2,2'-Bipyridine-5... 1 1
Potassium-transporting ATPase alpha chain 1 and Potassium-tran... 1 3
Indoles Metabolite Mukeic acid Family 1 1
Amino Acids and Derivatives Metabolite Flazine Family 3 2
Putative NP ZINC20113225 Family 2 0
9H-pyrido[3,4-b]indole-3-carboxamide NP (1-(3-bromophenyl)-9h-... 5 0
Putative NP ZINC15919780 Family 2 0
methyl 4-[(5Z)-5-(1H-indol-3-ylmethylidene)-4-oxo-2-sulfanylid... 1 0
2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-2-ium-8-carboxylate N... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00288184 CHEMBL75373 Bioactive NSC627682
CFAMM00288182 CHEMBL2051966 Bioactive trideuteriomethyl 9H-pyrido[3,4-b]indole-3-carboxylate
CFAMM00288197 CHEMBL305360 Bioactive CHEMBL305360
CFAMM00288154 DNC011246 Investigative Drug Ethyl 9H-pyrido[3,4-b]indole-3-carboxylate
CFAMM00288235 DNC012685 Investigative Drug 9H-beta-Carboline-3-carboxylic acid propyl ester
CFAMM00288153 DNC011244 Investigative Drug beta-Carboline-3-carboxylic acid t-butyl ester
CFAMM00288169 DNC012604 Investigative Drug (beta-CCE)9H-beta-Carboline-3-carboxylic acid
CFAMM00288158 DNC011810 Investigative Drug BETA-CCM
CFAMM00288157 DNC012697 Investigative Drug 9H-beta-Carboline-3-carboxylic acid butyl ester
CFAMM00288156 DNC011248 Investigative Drug sec-butyl 9H-pyrido[3,4-b]indole-3-carboxylate
CFAMM00288155 DNC011247 Investigative Drug ethyl 6-iodo-9H-pyrido[3,4-b]indole-3-carboxylate
CFAMM00288188 DNC012036 Investigative Drug 3-Methoxycarbonyl-2-methyl-9H-beta-carbolin-2-ium

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22920 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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