CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3289
Family Name 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 2A Ligand 1-ethyl-4-(2-methoxy-phenyl)-piperazine Family
No. of Seeds 21 No. of Other Members 13
Family Centroid CFAMM00288251 Functional Category Investigative Drug with Natural Product
Superfamily 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 2A Binder Superfamily 3
Class Class 1166

Cousin Family NamesSeedsMembers
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Acetylcholinesterase Inhibitor Edrophonium Family 7 40
Acetylcholinesterase Inhibitor Neostigmine Family 4 76
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
Calcium-activated potassium channel subunit alpha-1 Ligand Chl... 2 15
Squalene monooxygenase Inhibitor Tolnaftate Family 1 4
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 3 27
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 3 67
Substance-P receptor Ligand Ezlopitant Family 10 207
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
Transforming growth factor-beta Inhibitor ACE-011 Family 1 13
Dp-b99 family 1 5
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Neuropeptide Y receptor type 1 Ligand BMS-193885 Family 3 11
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 6 Ligand Sb 258585 Family 11 121
Multidrug resistance protein Inhibitor MM36 Family 1 1
Histamine H3 receptor Ligand UCL1972 Family 3 23
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
5-hydroxytryptamine receptor 6 Ligand SB-357134 Family 13 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 20 33
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 131
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Alpha-1A adrenergic receptor Ligand Ro-11-04253 Family 1 1
Peroxisome proliferator-activated receptor gamma and Peroxisom... 1 31
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Amyloid beta A4 protein Inhibitor SB-13 Family 1 2
Carbonic anhydrase 2 Inhibitor 4-methoxyphenylsulfamide Family 2 27
Histone deacetylase 1 Inhibitor 7-(4-(dimethylamino)phenoxy)-n... 2 1
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 12 44
Sodium-dependent serotonin transporter Inhibitor 4-(2-((dimeth... 3 1
Cholesteryl ester transfer protein Inhibitor Tetrahydroquinoli... 3 8
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Renin Inhibitor Ro-66-1168 Family 10 30
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Fatty-acid amide hydrolase 1 Inhibitor 2-fluorophenyl 4-(octyl... 15 9
Fatty-acid amide hydrolase 1 Inhibitor Propan-2-one O-4-(hexyl... 12 4
Fatty-acid amide hydrolase 1 Inhibitor Benzaldehyde O-4-ethoxy... 21 4
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 3
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 28 24
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 7
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Acetylcholinesterase Inhibitor 6-methyl-4-(4-phenylpiperazin-1... 6 622
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-00G... 16 4
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 6
D(4) dopamine receptor ligand AGN-PC-004XJQ family 2 1
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 10
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Pyruvate kinase PKLR and Pyruvate kinase PKM inhibitor AGN-PC-... 1 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 4 6
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 9 22
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(4-... 3 5
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 2
5-hydroxytryptamine receptor 6 ligand N-(3,5-dichlorophenyl)-4... 7 2
Alpha-2A adrenergic receptor and 5-hydroxytryptamine receptor ... 7 10
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 4 2
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 0
D(4) dopamine receptor and D(2) dopamine receptor ligand 7-[[4... 1 23
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 2
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-087THW family 1 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 12 10
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 8 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Estrogen receptor and Estrogen receptor beta ligand SureCN5681... 7 3
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 4 8
Neuropeptide S receptor and Prelamin-A/C ligand CHEMBL1352632 ... 1 25
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 1 0
Survival motor neuron protein and DNA-(apurinic or apyrimidini... 1 5
Acetylcholinesterase inhibitor AGN-PC-075N8G family 2 9
Nischarin inhibitor SureCN7818902 family 2 12
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 7
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 7 4
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 0
5-hydroxytryptamine receptor 6 ligand 1-(4-methoxy-3-piperazin... 6 3
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Survival motor neuron protein and ATP-dependent DNA helicase Q... 1 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
5-hydroxytryptamine receptor 6 ligand AGN-PC-0BRZ7B family 9 2
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 9
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 6 11
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-088O2I family 3 3
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 11 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 3 0
Gonadotropin-releasing hormone receptor ligand SureCN5756131 f... 5 7
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Neuropeptide Y receptor type 5 ligand 2-(7-chloro-3-oxo-1,4-be... 3 3
Neuropeptide Y receptor type 5 ligand N-[[4-[2-[7-(trifluorome... 1 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 5
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 0
Transient receptor potential cation channel subfamily V member... 1 0
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 2 3
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S)-4-(4-methoxya... 1 26
Amyloid beta A4 protein inhibitor SureCN6372684 family 2 7
Sodium-dependent serotonin transporter inhibitor 2-[2-[(dimeth... 3 3
Renin inhibitor 5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4... 5 9
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 0
D(2) dopamine receptor and Muscarinic acetylcholine receptor M... 1 0
Translocator protein inhibitor [11C]DAA1106 family 15 2
Translocator protein inhibitor N-methyl-2-[2-oxo-5-[4-(trifluo... 9 3
Translocator protein inhibitor 2-(5-bromo-2-oxo-1,3-benzoxazol... 1 0
Translocator protein inhibitor 2-(5-chloro-2-oxo-1,3-benzoxazo... 1 2
Translocator protein inhibitor N-methyl-2-[5-(N-methylanilino)... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 3
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 10 1
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 5 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 1
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 8
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 2 0
5-hydroxytryptamine receptor 7 ligand 1-(2-methoxyphenyl)-4-[2... 6 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 10
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (5R)-... 2 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-ethylbutanoyl)... 11 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 2
Glutamate receptor ionotropic, NMDA 2B and Potassium voltage-g... 2 1
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 10 2
Progesterone receptor ligand CHEMBL252850 family 2 0
Urotensin-2 receptor and Cytochrome P450 3A4 ligand 5-chloro-3... 2 1
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1A ligand AGN-PC-0034EG family 5 2
5-hydroxytryptamine receptor 1A ligand (1R,2R)-2-[4-(2,3-dihyd... 2 3
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 12 4
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZ6 family 3 6
Substance-P receptor ligand CP 141938 family 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 1A ligand AGN-PC-00FVK4 family 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 2
Neutrophil elastase inhibitor AGN-PC-04S1IE family 1 0
Survival motor neuron protein inhibitor N-(2-methoxyphenyl)-2-... 1 1
Sigma non-opioid intracellular receptor 1 ligand (5S)-5-[(4-hy... 1 5
Melanin-concentrating hormone receptor 1 ligand SureCN6779516 ... 1 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 9
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 12
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
Histamine H3 receptor ligand SureCN3057839 family 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 0
D(4) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 1 7
Sodium-dependent noradrenaline transporter and Sodium-dependen... 3 0
Peptide deformylase inhibitor (2S)-N-(cyclopropylmethyl)-N-[2-... 1 0
Hormone-sensitive lipase and Acetylcholinesterase inhibitor Su... 2 0
Prelamin-A/C and Nonstructural protein 1 inhibitor CHEMBL14536... 1 2
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 6
Arachidonate 5-lipoxygenase inhibitor ethyl (E)-3-(10H-phenoxa... 1 1
D(2) dopamine receptor and D(3) dopamine receptor ligand 1-(3-... 2 0
Sterol O-acyltransferase 1 inhibitor SureCN5812305 family 1 0
Leukotriene A-4 hydrolase inhibitor AGN-PC-087BON family 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-[2-... 1 1
2-methylpropyl 2-oxo-1,3-benzoxazole-3-carboxylate NP Isobutyl... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00288265 CHEMBL272854 Bioactive 3-[4-(4-cyclohexylpiperazin-1-yl)butyl]-1,3-benzoxazole-2-thione
CFAMM00288271 CHEMBL105345 Bioactive 1-[4-(4-fluorophenyl)butyl]-4-(2-methoxyphenyl)piperazine
CFAMM00288270 CHEMBL105747 Bioactive T5733063
CFAMM00288261 CHEMBL272610 Bioactive 3-[6-(4-cyclohexylpiperazin-1-yl)hexyl]-1,3-benzoxazol-2-one
CFAMM00288276 CHEMBL104805 Bioactive 1-[(E)-4-(4-fluorophenyl)but-3-enyl]-4-(2-methoxyphenyl)piperazine
CFAMM00288269 CHEMBL107141 Bioactive N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]cyclohexanecarbothioamide
CFAMM00288268 CHEMBL298920 Bioactive SureCN14027684
CFAMM00288258 CHEMBL269876 Bioactive 3-[2-(4-cyclohexylpiperazin-1-yl)ethyl]-1,3-benzoxazol-2-one
CFAMM00288267 CHEMBL1271151 Bioactive 1-(2-methoxyphenyl)-4-[2-(3-methoxyphenyl)ethyl]piperazine
CFAMM00288281 CHEMBL1202216 Bioactive 1-(2-methoxyphenyl)-4-[[(1S,2S)-2-phenylcyclopropyl]methyl]piperazine;hydrobromide
CFAMM00288257 CHEMBL48684 Bioactive 2-[(3S,5R)-3,5-dimethylpiperidin-1-yl]ethyl N-(2-methoxyphenyl)carbamate
CFAMM00288273 CHEMBL285577 Bioactive SureCN7991732
CFAMM00288279 DNC011851 Investigative Drug 1-Butyl-4-(2-methoxy-phenyl)-piperazine
CFAMM00288251 DNC011842 Investigative Drug 1-Ethyl-4-(2-methoxy-phenyl)-piperazine
CFAMM00288250 DNC011848 Investigative Drug 1-(2-Methoxy-phenyl)-4-propyl-piperazine
CFAMM00288282 DNC011255 Investigative Drug 1-(2-methoxyphenyl)-4-pentylpiperazine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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