CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3290
Family Name Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5-(4-chlorophenyl)nicotinamide Family
No. of Seeds 11 No. of Other Members 46
Family Centroid CFAMM00288331 Functional Category Investigative Drug with Natural Product
Superfamily ABC294640 Superfamily
Class Class 913

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
26S proteasome Inhibitor Bortezomib Family 7 65
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Smoothened homolog Inhibitor Vismodegib Family 1 19
Transient receptor potential cation channel subfamily V member... 16 295
Histidine decarboxylase Inhibitor Bf-derm1 Family 12 95
Farnesyltransferase beta subunit, putative Inhibitor Lonafarni... 36 87
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Coagulation factor X Inhibitor Otamixaban Family 9 21
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Substance-P receptor Ligand TAK-637 Family 18 63
ABC294640 family 5 75
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
JAK Inhibitor Momelotinib Family 33 83
Stress kinase p38 Inhibitor P38 Map Kinase Inhibitor Family 1 3
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
C-C chemokine receptor type 5 Ligand Sch 351125 Family 6 29
XL-888 family 16 85
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
Arachidonate 5-lipoxygenase Inhibitor Ici 207968 Family 3 7
Class II cytokine receptor Ligand IL-10 Family 7 45
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cyclin-dependent kinase 8 Inhibitor Oxindole 94 Family 2 3
Inhibitor of nuclear factor kappa-B kinase subunit epsilon and... 1 4
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-chlorophenyl)-5-... 2 8
Integrin beta-3 Inhibitor Elarofiban Family 28 45
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 3 5
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
MO15-related protein kinase Pfmrk Inhibitor (e)-1-(4-nitro-phe... 2 9
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Amine oxidase [flavin-containing] B Inhibitor Lazebemide Family 2 13
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Peroxisome proliferator-activated receptor gamma Ligand 2-chlo... 5 19
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 1 Ligand N-(2-phenylpropyl)qui... 3 1
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Amine oxidase [flavin-containing] A Inhibitor 6-chloro-n-(2-mo... 5 3
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 4
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
Transient receptor potential cation channel subfamily V member... 3 1
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 3 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 17 14
Vasopressin V2 receptor and Vasopressin V1a receptor ligand [2... 2 5
Rho-associated protein kinase 2 inhibitor N-(7-chloro-1-oxo-2H... 1 2
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 1 10
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 3 59
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Cannabinoid receptor 1 ligand AGN-PC-04YSUM family 7 6
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
Vasopressin V1b receptor ligand 2-[3-(3-chlorophenyl)-1-oxo-7-... 2 12
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
Nicotinamide phosphoribosyltransferase inhibitor 4-[(7-chloro-... 6 4
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
B1 bradykinin receptor ligand ELN-441958 family 1 0
Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... 2 3
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 19
Melanin-concentrating hormone receptor 1 ligand AGN-PC-072CVE ... 4 4
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
C-C chemokine receptor type 5 and Muscarinic acetylcholine rec... 3 0
Prelamin-A/C and Tyrosyl-DNA phosphodiesterase 1 inhibitor nif... 1 0
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Metabotropic glutamate receptor 2 ligand AGN-PC-00A1HD family 2 0
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Reverse transcriptase/RNaseH inhibitor AGN-PC-0755HU family 1 0
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 2 4
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 1 0
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Nicotinamide phosphoribosyltransferase inhibitor 4-[[(7-chloro... 1 1
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 1
Glycogen synthase kinase-3 beta inhibitor 7-(6-chloropyridin-2... 2 3
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 12
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 2-... 3 0
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6
C-C chemokine receptor type 5 ligand N-[3-[4-[4-bromo-N-[(3-cy... 2 4
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
Glucagon receptor ligand 3-[[4-[(1R,2S)-1-(4-chlorophenyl)-1-(... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Delta-type opioid receptor and Potassium voltage-gated channel... 2 0
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
Mast/stem cell growth factor receptor Kit and Mitogen-activate... 4 2
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[[(E)-3-(3,4-dichlo... 6 1
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 1 0
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 1 1
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Substance-P receptor ligand SureCN7796965 family 9 1
Protein kinase C theta type inhibitor (2-aminopyridin-3-yl)-[6... 4 1
Dipeptidyl peptidase 4 inhibitor [(2S,4S)-4-(4-quinolin-4-ylpi... 5 8
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 8 1
Melanin-concentrating hormone receptor 1 ligand SureCN4261878 ... 4 7
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 0
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 2 11
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Cannabinoid receptor 1 ligand SureCN4454684 family 2 0
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 6
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Seprase and Prolyl endopeptidase inhibitor [(2R)-1-[(2R)-2-[(2... 4 2
Motilin receptor ligand SureCN2768052 family 3 0
C-C chemokine receptor type 2 ligand SureCN5946889 family 2 6
Seprase and Prolyl endopeptidase inhibitor 7-chloro-N-[2-[(2S)... 3 3
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Acetylcholinesterase inhibitor N-[6-[4-[(6-chloro-1,2,3,4-tetr... 9 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[(4S)-4-(4-chlo... 4 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 17 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Coagulation factor X inhibitor 5-bromo-N-(5-chloropyridin-2-yl... 1 1
C-C chemokine receptor type 2 ligand (E)-3-(3,4-dichlorophenyl... 3 2
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 1
Substance-K receptor and Substance-P receptor ligand 3,5-dichl... 3 0
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Platelet-activating factor receptor ligand SureCN9853140 family 3 3
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 1
KiSS-1 receptor ligand SureCN5132924 family 2 4
Coagulation factor X inhibitor N-[2-[(5-chloropyridin-2-yl)sul... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor SureCN4998361 family 1 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
Cytochrome P450 2C9 inhibitor AGN-PC-04XDND family 1 3
Macrophage colony-stimulating factor 1 receptor ligand AGN-PC-... 3 0
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 10 14
Translocator protein inhibitor N,N-dibutyl-2-(7-chloro-2-pheny... 3 1
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 17
Nociceptin receptor and Mu-type opioid receptor ligand N-[(1R,... 4 2
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 1 0
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 1 1
Mitogen-activated protein kinase 14 inhibitor SureCN14185127 f... 2 0
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 2 2
P2X purinoceptor 7 inhibitor 2-chloro-N-[(1-hydroxy-3,3-dimeth... 1 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 3
Poly [ADP-ribose] polymerase 1 inhibitor SureCN3553433 family 22 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R9GP family 5 0
Hepatocyte growth factor receptor ligand N-[2-(3-chlorophenyl)... 2 2
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 2
C-C chemokine receptor type 3 ligand AGN-PC-075CFA family 3 1
C-C chemokine receptor type 5 ligand methyl 4-[benzyl-[1-[4-[(... 1 0
Glucocorticoid receptor ligand 5-[(6-methylpyridin-2-yl)methyl... 3 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 1 0
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 7 2
Peptide deformylase and Peptide deformylase 1A, chloroplastic/... 1 1
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [2-(a... 1 2
Vesicular acetylcholine transporter and Sigma non-opioid intra... 2 0
C-X-C chemokine receptor type 2 ligand 6-chloro-N-(4-fluorophe... 1 0
3-[(3S)-2,5-dioxo-3,4-dihydro-1H-1,4-benzodiazepin-3-yl]-N-pyr... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00288289 CHEMBL1269991 Bioactive AGN-PC-09M7AK
CFAMM00288303 CHEMBL1801563 Bioactive 4-[[(E)-but-2-enyl]-[(2-chlorophenyl)methyl]amino]-N-(pyridin-3-ylmethyl)benzamide
CFAMM00288314 CHEMBL482527 Bioactive AGN-PC-077PQM
CFAMM00288285 CHEMBL1801559 Bioactive 4-[(2-chlorophenyl)methyl-(3-methylbutyl)amino]-N-(pyridin-3-ylmethyl)benzamide
CFAMM00288304 CHEMBL1801562 Bioactive 4-[(2-chlorophenyl)methyl-(3-methylbut-2-enyl)amino]-N-(pyridin-3-ylmethyl)benzamide
CFAMM00288291 CHEMBL2398757 Bioactive N-[(2R)-1-[(4R)-4-(4-chlorophenyl)-3,3-dimethylpiperidin-1-yl]-3-methyl-1-oxobutan-2-yl]pyridine-3-carboxamide
CFAMM00288331 DNC011258 Investigative Drug N-benzyl-5-(4-chlorophenyl)nicotinamide
CFAMM00288343 DNC011256 Investigative Drug N-(2-chlorobenzyl)-5-(4-chlorophenyl)nicotinamide
CFAMM00288342 DNC011257 Investigative Drug 5-(4-chlorophenyl)-N-(2-methylbenzyl)nicotinamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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