CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3296
Family Name Renin Inhibitor CP-305202 Family
No. of Seeds 9 No. of Other Members 30
Family Centroid CFAMM00288362 Functional Category Investigative Drug with Natural Product
Superfamily Renin Inhibitor CP-305202 Superfamily
Class Class 2009

Cousin Family NamesSeedsMembers
Multidrug resistance-associated protein 1 Inhibitor Biricodar ... 6 40
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Coagulation factor X Inhibitor Otamixaban Family 9 21
Smoothened homolog Inhibitor LDE225 Family 3 76
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
MO15-related protein kinase Pfmrk Inhibitor WR-289010 Family 2 506
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Oxytocin receptor and Vasopressin V1a receptor Ligand L-372662... 31 23
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-[3... 1 2
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 391
Leukotriene B4 receptor 1 ligand AGN-PC-04XM3V family 3 10
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 18
Pol polyprotein inhibitor Carbamic acid, ((2-hydroxy-1,4-bis(p... 21 1
cAMP-dependent protein kinase type II-alpha regulatory subunit... 2 4
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Somatostatin receptor type 5 ligand AGN-PC-088VSK family 2 3
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 13 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
Acetylcholinesterase and Butyrylcholinesterase inhibitor [3-[[... 3 68
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Thromboxane-A synthase and Thromboxane A2 receptor ligand Sure... 5 37
Glycylpeptide N-tetradecanoyltransferase 2 and Glycylpeptide N... 8 10
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 4
Prostaglandin D2 receptor 2 ligand SureCN137822 family 3 0
Endothelin-1 receptor ligand SureCN8118632 family 4 5
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 14
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 11
Retinoic acid receptor RXR-alpha ligand 6-[(3-butoxy-5,5,8,8-t... 2 2
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Proteinase-activated receptor 1 ligand (3R,3aR,4S,5R,6S,7aS)-5... 2 3
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 4
Cholinesterase and Acetylcholinesterase inhibitor 5-hydroxy-7-... 5 19
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Hydroxycarboxylic acid receptor 2 and Cytochrome P450 2C9 liga... 2 6
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Caspase-1 inhibitor (3S)-3-[[2-[3-(naphthalene-2-carbonylamino... 1 0
Beta-1 adrenergic receptor and Beta-3 adrenergic receptor liga... 2 2
Thromboxane-A synthase inhibitor (E)-7-[4-[5-[(2S,4S,5R)-5-[(Z... 3 9
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 15
Pol polyprotein inhibitor Tertiary Amide deriv. 58 family 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 4 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 4 2
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 1
Beta-3 adrenergic receptor ligand SureCN5704018 family 4 1
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 7 2
Cysteinyl leukotriene receptor 1 ligand 2-[2-[5-[[3-[(E)-2-(6,... 1 8
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 3
Retinoic acid receptor RXR-alpha and Retinoic acid receptor RX... 1 0
Hepatocyte growth factor receptor ligand 2-[(2-fluorophenyl)me... 6 11
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 1 4
Histamine H1 receptor and Histamine H2 receptor ligand SureCN6... 1 3
Histamine H1 receptor and Histamine H2 receptor ligand SureCN5... 3 6
Tyrosine-protein kinase ABL1 inhibitor N-(5-bromopyridin-2-yl)... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 1 0
Cathepsin D inhibitor 5-[2-hydroxy-4-[[4-[(Z)-(4-oxo-2-sulfany... 1 0
8-[[(2S)-2-pyridin-3-ylpiperidin-1-ium-1-yl]methyl]chromen-4-o... 3 0
NP 3-(2,5-dimethyl-7-oxo-3-phenyl-7h-furo[3,2-g]chromen-6-yl)-... 19 0
NP (e)-6-(4,6-dimethoxy-7-methyl-3-oxo-1,3-dihydroisobenzofura... 4 1
NP N-(2-(3,4-dimethoxyphenyl)-4-oxo-4h-chromen-6-yl)nicotinami... 6 1
7-[((1S,9R)-6-oxo-7,11-diazatricyclo[7.3.1.0<2,7>]trideca-2,4-... 1 0
Putative NP ZINC20761495 Family 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00288365 CHEMBL469610 Bioactive 4-[4-[2-[[(2R)-2-hydroxy-2-pyridin-3-ylethyl]amino]ethyl]phenyl]-N-methylsulfonyl-2-propan-2-yloxybenzamide;dihydrochloride
CFAMM00288377 CHEMBL445481 Bioactive SureCN4584202
CFAMM00288360 CHEMBL470292 Bioactive 4-[4-[2-[[(2R)-2-hydroxy-2-pyridin-3-ylethyl]amino]ethyl]phenyl]-2-propan-2-yloxybenzoic acid
CFAMM00288362 DNC011265 Investigative Drug CP-305202

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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