CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFID3298
Family Name Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyclopentyl)-1h-indole-5-carbonitrile Family
No. of Seeds 94 No. of Other Members 23
Family Centroid CFAMM00288497 Functional Category Investigative Drug with Natural Product
Superfamily 5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin transporter Binder Superfamily
Class Class 1116

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Neuronal acetylcholine receptor subunit alpha-4 Ligand Varenic... 3 54
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Acetylcholinesterase Inhibitor Tacrine Family 12 515
D(2) dopamine receptor Ligand Sertindole Family 3 173
Gamma-aminobutyric acid A receptor Ligand Bromazepam Family 2 60
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor qu... 2 60
Prothrombin Inhibitor Ximelegatran Family 8 157
G protein-activated inward rectifier potassium channel 4 Ligan... 3 48
Transient receptor potential cation channel subfamily V member... 15 158
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Transient receptor potential cation channel subfamily V member... 15 457
Neuromedin-K receptor Ligand SB222200 Family 17 235
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Substance-P receptor Ligand GSK424887 Family 8 184
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 23 63
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Histone deacetylase 1 Inhibitor Resminostat Family 2 5
Amg 423 family 7 47
E7820 family 9 56
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Cyclin-dependent kinase 5 Inhibitor 9-nitropaullone Family 2 13
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Lethal factor Inhibitor N,n'-bis(4-amino-2-methylquinolin-6-yl... 2 11
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-chlorophenyl)-5-... 2 8
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
TGF-beta receptor type-1 Ligand Naphthyridine Inhibitor Family 3 6
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Platelet-derived growth factor receptor alpha and Platelet-der... 5 48
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 22
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 16
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 43 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Mast/stem cell growth factor receptor Kit Ligand 9-bromo-5,11-... 1 0
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Indoleamine 2,3-dioxygenase 1 Inhibitor N-[2-(indol-3-yl)ethyl... 2 2
Metabotropic glutamate receptor 5 Ligand 2-methyl-6-(4-phenylb... 6 32
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Mineralocorticoid receptor and Androgen receptor Ligand WAY-25... 10 26
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 6
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
Histamine H4 receptor Ligand A-943931 Family 14 11
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 4 33
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Kinesin-like protein KIF11 Inhibitor 2-(trifluoromethyl)-9h-ca... 5 0
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 3
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
Translocator protein Inhibitor 5-phenyl-6-thia-10b-aza-benzo[e... 1 2
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 7,12-d... 1 0
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 18 17
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 3-fluoro-5-(2-methylq... 3 2
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Metabotropic glutamate receptor 1 Ligand (e)-4,4-dimethyl-1-qu... 2 2
Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)ph... 7 33
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Trypsin Inhibitor 4-(5-nitro-indol-1-ylmethyl)-benzamidine Family 2 0
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Protein kinase C theta type and Protein kinase C delta type in... 7 17
Dipeptidyl peptidase 1 inhibitor (2S)-2-amino-N-[(1S)-1-cyano-... 2 14
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 0
Protein kinase C theta type and Protein kinase C delta type in... 16 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
5-hydroxytryptamine receptor 6 ligand N-methyl-1-[(1R)-6-(1H-p... 3 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 14
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 3
Histone deacetylase 3 and Histone deacetylase 6 inhibitor Tria... 20 37
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
5-hydroxytryptamine receptor 6 ligand CHEMBL1950756 family 8 8
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 5 0
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Cathepsin L1 inhibitor Bio2_000267 family 9 1
Vascular endothelial growth factor receptor 2 and Receptor-typ... 7 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Acetylcholinesterase and Cholinesterase inhibitor 3,8-DIAMINO-... 2 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 4 5
Progesterone receptor and Androgen receptor ligand 5-[4-[(Z)-C... 2 5
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 1 1
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 1 inhibi... 2 0
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 10 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 3
Cannabinoid receptor 2 ligand AGN-PC-09M5PW family 12 2
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Sodium-dependent serotonin transporter inhibitor SureCN6087392... 1 1
Sodium-dependent serotonin transporter inhibitor SureCN6087152... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 2
Cathepsin K inhibitor SureCN2155973 family 3 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-072CVE ... 4 4
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 4 0
D(4) dopamine receptor and D(1A) dopamine receptor ligand 2-[[... 5 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Prostaglandin G/H synthase 2 inhibitor SureCN6998947 family 1 1
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 0
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 10 9
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 4 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 7 14
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Progesterone receptor and Mineralocorticoid receptor ligand AG... 6 1
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 5 0
Sodium-dependent serotonin transporter inhibitor SureCN9171444... 2 0
Glucocorticoid receptor ligand SureCN5650626 family 17 25
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Glucocorticoid receptor ligand SureCN4198717 family 5 0
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 5 1
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 1
Glucocorticoid receptor and Androgen receptor ligand AGN-PC-0A... 3 0
Glucocorticoid receptor ligand AGN-PC-0A9RHA family 1 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 2
Hepatocyte growth factor receptor ligand AGN-PC-08XYH3 family 1 0
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00AP1L ... 14 7
Sigma non-opioid intracellular receptor 1 ligand SureCN7434677... 1 0
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
5-hydroxytryptamine receptor 6 and Muscarinic acetylcholine re... 7 3
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Sodium-dependent serotonin transporter inhibitor 3-[[(3S)-1-az... 1 1
5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4
C-X-C chemokine receptor type 3 ligand (6aR,9R)-N-phenyl-4-(2-... 5 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 5 3
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... 7 9
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 12 0
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Cytochrome P450 2D6 and Cytochrome P450 2C19 inhibitor Demethy... 1 4
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 5 6
Melanin-concentrating hormone receptor 2 ligand N,N-dimethyl-3... 2 2
Melanin-concentrating hormone receptor 2 ligand N-[(1R)-1'-(9H... 4 1
Melanin-concentrating hormone receptor 2 and Sodium-dependent ... 2 1
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
CGMP-dependent protein kinase inhibitor AGN-PC-075XJ0 family 9 1
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 2 0
Transporter and Sodium-dependent serotonin transporter inhibit... 2 1
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
Prostaglandin D2 receptor 2 ligand SureCN317401 family 3 8
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1
5-hydroxytryptamine receptor 6 ligand 9-(2-bromophenyl)sulfony... 2 0
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 8 0
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 6
Serine/threonine-protein kinase Chk1 inhibitor 3-[5-(piperidin... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 4
Motilin receptor ligand SureCN2768052 family 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 5 2
5-hydroxytryptamine receptor 2A ligand (3R,4R)-3-(2-phenyl-1H-... 1 18
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-methylsulfany... 1 1
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 2 2
5-hydroxytryptamine receptor 6 ligand 5-[3-(2-aminoethyl)indol... 1 0
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Glucocorticoid receptor ligand 3,3,3-trifluoro-N-[(3S)-3-[1-(4... 10 4
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
C-C chemokine receptor type 2 ligand SureCN5947024 family 11 0
CGMP-dependent protein kinase inhibitor methyl 2-[[4-[5-(4-flu... 6 1
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Glycogen synthase kinase-3 alpha and Glycogen synthase kinase-... 2 1
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 1 0
5-hydroxytryptamine receptor 5A and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 7
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
Capsid scaffolding protein inhibitor AC1O583J family 5 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
D(4) dopamine receptor and D(1A) dopamine receptor ligand AGN-... 1 0
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
5-hydroxytryptamine receptor 7 ligand 6-[(2R)-2-[2-(4-methylpi... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(... 2 1
5-hydroxytryptamine receptor 1D ligand AGN-PC-01NTBS family 1 1
5-hydroxytryptamine receptor 6 ligand 3,4-dichloro-N-[3-[[(2R)... 5 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
CGMP-dependent protein kinase inhibitor AGN-PC-075INU family 1 1
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 1 0
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
Protein kinase C theta type and Protein kinase C delta type in... 4 5
C-X-C chemokine receptor type 2 and Cytochrome P450 2C9 ligand... 1 7
Sigma non-opioid intracellular receptor 1 ligand 1-phenyl-4-(2... 1 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
CGMP-dependent protein kinase inhibitor 2-[[4-[5-(4-fluorophen... 1 0
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 4 0
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 7 ligand 6-bromo-1-[2-[4-(cyclopr... 2 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 0
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
Prostaglandin G/H synthase 2 inhibitor SureCN6345015 family 6 1
5-hydroxytryptamine receptor 6 and Cytochrome P450 3A4 ligand ... 1 0
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1
Thromboxane-A synthase inhibitor AGN-PC-07BYVF family 1 0
Thymidylate synthase inhibitor AGN-PC-00EUGY family 2 7
Nociceptin receptor ligand SureCN3543370 family 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
5-hydroxytryptamine receptor 6 ligand 2-[[(1Z)-1-[5-(benzenesu... 1 0
5-hydroxytryptamine receptor 6 ligand 4-bromo-N-[3-[[(2S)-1-me... 4 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 1
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 6 4
Histamine H3 receptor ligand AGN-PC-09M6FC family 1 9
Potassium voltage-gated channel subfamily A member 5 and Volta... 2 4
P2X purinoceptor 7 inhibitor SureCN1194877 family 1 6
D(2) dopamine receptor and D(3) dopamine receptor ligand methy... 2 1
Acyl-CoA:cholesterol acyltransferase inhibitor AGN-PC-00GCQW f... 2 1
Peptide deformylase and Peptide deformylase 1A, chloroplastic/... 1 1
Nociceptin receptor and Mu-type opioid receptor ligand SureCN1... 1 0
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 1 1
Insulin receptor ligand 2,5-dihydroxy-3-(1H-indol-3-yl)-6-phen... 1 0
Coagulation factor X inhibitor (3R,4R)-3-N-[2-fluoro-4-(2-oxop... 1 0
Nonstructural protein 1 and Lysine-specific demethylase 4E inh... 1 0
Cytochrome P450 2C19 inhibitor CHEMBL1449918 family 1 0
Lysine-specific demethylase 4E and Lethal(3)malignant brain tu... 1 1
Hexokinase and Farnesyl pyrophosphate synthase inhibitor AC1NQ... 1 0
Farnesyl pyrophosphate synthase inhibitor [[(5-benzylpyridin-3... 1 0
Kinesin-like protein KIF11 inhibitor AGN-PC-077SFB family 1 0
Proto-oncogene Wnt-3 inhibitor CHEMBL563202 family 2 0
Azoles Metabolite 2,5-Dimethyl-1H-pyrrole Family 1 4
methyl-1H-pyrrole NP (z)-2-((3,4-dimethyl-1h-pyrrol-2-yl)methy... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00288463 CHEMBL146976 Bioactive AC1N5SOM
CFAMM00288520 CHEMBL331241 Bioactive 5-Methyltryptamine
CFAMM00288495 CHEMBL554369 Bioactive 3-[[(2S)-1-methylpyrrolidin-2-yl]methyl]-1H-indole;hydrochloride
CFAMM00288508 CHEMBL188409 Bioactive SureCN7530566
CFAMM00288488 CHEMBL40815 Bioactive 1-(3H-benzo[e]indol-1-yl)propan-2-amine
CFAMM00288440 CHEMBL1275731 Bioactive SureCN6087352
CFAMM00288501 CHEMBL1276165 Bioactive SureCN6087348
CFAMM00288483 CHEMBL600263 Bioactive AGN-PC-07R9Y1
CFAMM00288462 CHEMBL180630 Bioactive AGN-PC-009ASA
CFAMM00288518 CHEMBL1275671 Bioactive SureCN6087628
CFAMM00288494 CHEMBL1276960 Bioactive SureCN6088726
CFAMM00288447 CHEMBL1277048 Bioactive SureCN6087824
CFAMM00288507 CHEMBL590487 Bioactive AGN-PC-07R9TJ
CFAMM00288514 CHEMBL294398 Bioactive AGN-PC-073TLV
CFAMM00288471 CHEMBL357034 Bioactive 2-(5-tert-butyl-1H-indol-3-yl)-N-methylethanamine
CFAMM00288482 CHEMBL2380983 Bioactive 5-[(1R,2R)-2-[(dimethylamino)methyl]cyclopropyl]-1H-indole-3-carbonitrile
CFAMM00288439 CHEMBL562118 Bioactive SureCN6085677
CFAMM00288500 CHEMBL1276166 Bioactive SureCN6101555
CFAMM00288461 CHEMBL57232 Bioactive AGN-PC-00ORPS
CFAMM00288517 CHEMBL1276298 Bioactive SureCN6087334
CFAMM00288493 CHEMBL1276961 Bioactive SureCN6086711
CFAMM00288446 CHEMBL1277049 Bioactive SureCN6087738
CFAMM00288451 CHEMBL151502 Bioactive 2-(5-cyclopentyl-1H-indol-3-yl)ethanamine
CFAMM00288524 CHEMBL1275707 Bioactive SureCN6089353
CFAMM00288481 CHEMBL2380980 Bioactive SureCN6084533
CFAMM00288499 CHEMBL1275792 Bioactive SureCN6087959
CFAMM00288470 CHEMBL1275670 Bioactive SureCN6087591
CFAMM00288460 CHEMBL599684 Bioactive AGN-PC-07R9WO
CFAMM00288492 CHEMBL1276962 Bioactive SureCN6086982
CFAMM00288445 CHEMBL444341 Bioactive 5-TERT-BUTYLTRYPTAMINE
CFAMM00288505 CHEMBL423029 Bioactive SureCN13209526
CFAMM00288477 CHEMBL150798 Bioactive AGN-PC-00OXW9
CFAMM00288487 CHEMBL373211 Bioactive 3-[(1R,2S)-2-[(dimethylamino)methyl]cyclopropyl]-1H-indole-5-carbonitrile
CFAMM00288516 CHEMBL1276299 Bioactive SureCN6088195
CFAMM00288450 CHEMBL606244 Bioactive AGN-PC-07R9V5
CFAMM00288523 CHEMBL1275708 Bioactive SureCN6086908
CFAMM00288498 CHEMBL147454 Bioactive N-[2-(5-tert-butyl-1H-indol-3-yl)ethyl]propan-1-amine
CFAMM00288512 CHEMBL1162965 Bioactive SureCN6795965
CFAMM00288469 CHEMBL1277138 Bioactive SureCN6087698
CFAMM00288480 CHEMBL605535 Bioactive 3-[2-[(2S,4S)-4-benzyl-1-methylpiperidin-2-yl]ethyl]-1H-indole-5-carbonitrile
CFAMM00288457 CHEMBL539656 Bioactive 3-[(1S,2R)-2-[(dimethylamino)methyl]cyclopentyl]-1H-indole-5-carbonitrile
CFAMM00288459 CHEMBL195774 Bioactive SureCN6615017
CFAMM00288476 CHEMBL1275793 Bioactive SureCN6088177
CFAMM00288486 CHEMBL197354 Bioactive 3-[(1S,2S)-2-[(dimethylamino)methyl]cyclopropyl]-1H-indole-7-carbonitrile
CFAMM00288449 CHEMBL1275729 Bioactive SureCN6089286
CFAMM00288465 CHEMBL554074 Bioactive 3-[(1S,2S)-2-[[ethyl(methyl)amino]methyl]cyclopentyl]-1H-indole-5-carbonitrile
CFAMM00288522 CHEMBL291739 Bioactive AGN-PC-073TMD
CFAMM00288456 CHEMBL196468 Bioactive UNII-WR55VTJ7AL
CFAMM00288443 CHEMBL600890 Bioactive AGN-PC-07R9V8
CFAMM00288475 CHEMBL1275794 Bioactive SureCN6087713
CFAMM00288485 CHEMBL592776 Bioactive AGN-PC-07R9V6
CFAMM00288464 CHEMBL539470 Bioactive 3-[(1R,2S)-2-[(dimethylamino)methyl]cyclopentyl]-1H-indole-5-carbonitrile
CFAMM00288496 CHEMBL1277229 Bioactive SureCN6089167
CFAMM00288441 CHEMBL1275730 Bioactive SureCN6088212
CFAMM00288502 CHEMBL54364 Bioactive AGN-PC-02TBQ0
CFAMM00288474 CHEMBL197966 Bioactive 3-[(1S,2S)-2-[(dimethylamino)methyl]cyclopropyl]-1H-indole-6-carbonitrile
CFAMM00288484 CHEMBL1276226 Bioactive SureCN6088301
CFAMM00288497 DNC011268 Investigative Drug 3-(3-aminocyclopentyl)-1H-indole-5-carbonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24517 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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