CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3304
Family Name Metabotropic glutamate receptor 5 Ligand N-(1,3-diphenyl-1h-pyrazol-5-yl)benzamide Family
No. of Seeds 6 No. of Other Members 37
Family Centroid CFAMM00288693 Functional Category Investigative Drug
Superfamily Metabotropic glutamate receptor 5 and Arachidonate 5-lipoxygenase Binder Superfamily
Class Class 1394

Cousin Family NamesSeedsMembers
Macrophage colony-stimulating factor 1 Inhibitor ABT-869 Family 8 56
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
PHA848125 family 13 138
Smoothened homolog Inhibitor LY2940680 Family 3 18
Cyclin-dependent kinase 2 Inhibitor N-(5-cyclopropyl-1h-pyrazo... 6 62
Aurora kinase B and Aurora kinase C Inhibitor PHA-680632 Family 5 72
Metabotropic glutamate receptor 5 Ligand N-(1,4-diphenyl-1h-py... 3 35
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Adenosine receptor A3 Ligand 2-aminoquinazoline-4-carboxyanili... 4 3
RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... 20 90
Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... 7 77
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 55
Sphingosine 1-phosphate receptor 1 ligand SureCN3029336 family 4 8
Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... 10 5
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07C64P fa... 8 4
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 18
Poly [ADP-ribose] polymerase 1 inhibitor 2-[2-[4-(1H-indazol-3... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-088VMM fa... 1 12
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... 9 11
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Mitogen-activated protein kinase 14 inhibitor AGN-PC-00CSYM fa... 2 15
Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... 5 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 19
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Coagulation factor X and Trypsin-1 inhibitor SureCN3836037 family 5 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Coagulation factor X inhibitor AGN-PC-0749BY family 5 9
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
G1/S-specific cyclin-E2 and G1/S-specific cyclin-E1 inhibitor ... 5 10
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Hepatocyte growth factor receptor ligand 5-[(6-phenyl-[1,2,4]t... 6 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... 5 3
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 17 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 6
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 6 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,... 3 1
Cannabinoid receptor 2 ligand N-(1-adamantyl)-7-oxo-4-pentyl-2... 5 0
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor AGN-... 1 1
Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... 9 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 6 6
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 7
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-04VNKY family 1 4
Poly [ADP-ribose] polymerase 1 inhibitor SureCN6479420 family 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-00CRQ3 fa... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00288688 DNC011288 Investigative Drug 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
CFAMM00288697 DNC013021 Investigative Drug 4-nitro-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
CFAMM00288696 DNC013023 Investigative Drug 3-nitro-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
CFAMM00288695 DNC013022 Investigative Drug 4-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
CFAMM00288693 DNC013024 Investigative Drug N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26194 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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