CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3307
Family Name Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ionotropic, NMDA 1 Ligand Eliprodil Family
No. of Seeds 9 No. of Other Members 7
Family Centroid CFAMM00288723 Functional Category Investigative Drug
Superfamily potassium channel subunit alpha-1 ligand phenanthrene derivative Halofantrine Lumefantrine Superfamily
Class Class 225

Cousin Family NamesSeedsMembers
Opioid receptor ligand synthetic opioid methadone analog Dextr... 2 108
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Histamine H1 receptor Ligand Terfenadine Family 3 50
Alpha adrenergic receptor Ligand Pseudoephedrine Family 4 96
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
D(2) dopamine receptor Ligand Haloperidol Family 5 53
Histamine H1 receptor Ligand Clemastine Family 5 76
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Delta-type opioid receptor Ligand Loperamide Family 8 55
Histamine H1 receptor Ligand Diphenhydramine Family 5 75
Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Histamine H1 receptor Ligand Chlophedianol Family 4 46
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Mu-type opioid receptor ligand opiate Methadyl Acetate Family 5 9
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Sodium/potassium-transporting ATPase subunit alpha-1 inhibitor... 1 1
Eptazocine Hbr family 6 8
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
Pitolisant family 4 24
Muscarinic acetylcholine receptor Ligand Umeclidinium Family 7 50
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Choline kinase alpha Inhibitor Hemicholinium-3 Family 4 0
Peptide deformylase, mitochondrial Inhibitor Hydroxamates Family 6 17
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13
Adenosine receptor A3 and D(2) dopamine receptor Ligand (+)-bu... 5 14
Substance-P receptor Ligand L-733060 Family 19 71
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
Cytochrome P450 2D6 Inhibitor Bs 7840 Family 4 9
Sodium-dependent noradrenaline transporter Inhibitor (r)-1-((s... 3 8
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 3 1
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3
Potassium voltage-gated channel subfamily H member 2 Ligand [1... 2 23
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 44 3
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-ri... 5 12
Sodium-dependent dopamine transporter and Sodium-dependent nor... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 4 19
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 5 6
Glutamate receptor ionotropic, NMDA 3A and Glutamate receptor ... 2 1
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Melanocortin receptor 4 and Melanocortin receptor 3 ligand Sur... 6 53
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 11
Sigma non-opioid intracellular receptor 1 ligand (1R)-1'-benzy... 7 27
Sigma non-opioid intracellular receptor 1 ligand 2-[(3R)-1'-(c... 2 0
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Vesicular acetylcholine transporter inhibitor BENZOVESAMICOL f... 7 4
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 1 1
C-C chemokine receptor type 1 ligand SureCN7463390 family 1 6
Substance-P receptor ligand 4-[[3,5-bis(trifluoromethyl)phenyl... 2 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
D(2) dopamine receptor and D(3) dopamine receptor ligand 4-(4-... 1 3
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 6 3
Vesicular acetylcholine transporter inhibitor 2-Naphthalenol, ... 3 2
Substance-P receptor ligand 1-[[(1R,2R,3S)-3-[[3,5-bis(trifluo... 4 3
Sodium-dependent dopamine transporter and Transporter inhibito... 2 0
Substance-P receptor ligand AGN-PC-03NGZP family 3 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 0
Substance-P receptor ligand SureCN8415737 family 3 4
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 12
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 3 0
Vesicular acetylcholine transporter inhibitor (1R,2R)-2-spiro[... 3 2
Squalene synthase inhibitor 3-[2-(4-phenylphenyl)ethynyl]-1-az... 2 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 3 3
Sodium-dependent dopamine transporter and Transporter inhibito... 2 0
Sigma non-opioid intracellular receptor 1 and Vesicular acetyl... 1 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-0793IB... 2 0
Nociceptin receptor ligand SB-612111 family 1 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 1
C-C chemokine receptor type 1 ligand 2-chloro-N-[3-[4-(4-chlor... 8 25
C-C chemokine receptor type 1 ligand N-[3-[4-(4-chlorophenyl)-... 1 1
C-C chemokine receptor type 1 ligand SureCN9108276 family 1 0
Membrane primary amine oxidase and Amine oxidase [flavin-conta... 2 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
C-C chemokine receptor type 1 ligand SureCN9108965 family 1 0
Dibenzocycloheptenes Metabolite E-10-Hydroxynortriptyline Family 1 0
7-phenyl-1,3-diazaadamantan-6-ol NP ZINC32124180 Family 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00288726 CHEMBL417637 Bioactive SureCN9330147
CFAMM00288723 DNC011295 Investigative Drug ELIPRODIL

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27515 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543