CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID332
Family Name Neprilysin Inhibitor Thiorphan Family
No. of Seeds 41 No. of Other Members 68
Family Centroid CFAMM00187805 Functional Category Investigative Drug with Natural Product
Superfamily Neprilysin Inhibitor Thiorphan Superfamily
Class Class 1538

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Oxytocin receptor Ligand Oxytocin Family 30 182
Penicillin binding protein inhibitor β-lactam aminopenicillin ... 12 359
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Tyrosine 3-monooxygenase Inhibitor L-phenylalanine Family 19 144
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Penicillin binding protein inhibitor β-lactam ureidopenicillin... 4 9
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Angiotensin-converting enzyme Inhibitor Temocapril Family 4 15
Thymopentin family 20 133
Puromycin-sensitive aminopeptidase Inhibitor CHR-2797 Family 1 2
Angiotensin-converting enzyme and Neprilysin Inhibitor M100,24... 18 60
Dopamine reuptake Inhibitor Amineptine Family 2 5
Iofolastat I-124 family 6 33
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
72 kDa type IV collagenase Inhibitor Batimastat Family 6 52
Integrin alpha-V and Integrin beta-3 Inhibitor C[rgd-(s)-alpha... 19 95
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Neuromedin-K receptor Ligand Senktide Family 15 22
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Gamma-g... 2 1
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Penicillin-binding protein 1B Inhibitor N-benzoyl-d-alanine Fa... 1 40
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Farnesyltransferase beta subunit, putative and Protein farnesy... 24 82
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Cathepsin B and Cathepsin K Inhibitor (s)-1-benzylcyclopentyl ... 11 5
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Beta-secretase 1 Inhibitor KMI-172 Family 3 0
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 6 24
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 3 21
Delta-type opioid receptor Ligand H-cxp-ala-gly-phe-leu-oh Family 1 8
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Substance-P receptor Ligand [sar9,met(o2)11]-sp Family 34 9
Cytosolic phospholipase A2 Inhibitor Methyl 2-(2-oxo-8-phenylo... 2 3
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-154957 Family 2 3
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Inhibit... 5 23
Receptor-type tyrosine-protein phosphatase C Ligand Asp-brpmp-... 2 0
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 49 19
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Protein farnesyltransferase subunit beta Inhibitor L-739750 Fa... 4 0
Genome polyprotein Inhibitor Acasp-glu-dif-glu-cha-cys Family 13 17
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Voltage-dependent calcium channel gamma-1 subunit Ligand 4-(3,... 6 9
Aminopeptidase N Inhibitor 2-benzyl-n1-hydroxy-n3-(4-phenylbut... 5 3
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Leukotriene A-4 hydrolase Inhibitor SA-6541 Family 4 32
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Cholecystokinin receptor type A Ligand CR-1795 Family 19 41
Protein farnesyltransferase subunit beta and Protein farnesylt... 3 5
Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[a... 13 1
Carboxypeptidase B and Carboxypeptidase B2 inhibitor (2S)-7-am... 3 9
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[... 14 2
Renin and Cathepsin D inhibitor (3S)-4-[[6-acetamido-2-[[3-nap... 6 26
Pol polyprotein inhibitor Lysine Sulfonamide 11c family 3 73
Angiotensin-converting enzyme inhibitor SureCN9749318 family 2 0
Neprilysin inhibitor SureCN489232 family 3 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 2
Neprilysin inhibitor AGN-PC-047EOK family 7 4
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 0
Angiotensin-converting enzyme inhibitor Zofenoprilat family 2 14
Neprilysin inhibitor (2S)-2-methyl-3-oxo-3-[[(2S)-1-phenyl-3-s... 5 2
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 6 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-cycl... 1 6
Dipeptidyl peptidase 4 inhibitor (3S)-4-[(3R)-3-amino-4-(2,4,5... 1 1
Angiotensin-converting enzyme inhibitor (2S,4S,5R)-1-[(2R)-2-a... 1 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Endothelin-converting enzyme 1 and Cathepsin D inhibitor N-[(2... 6 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-1-... 3 3
Angiotensin-converting enzyme inhibitor (2S)-2-[[(3R)-5-(carbo... 6 4
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 5 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)... 5 8
Neprilysin inhibitor SureCN7437961 family 2 6
Pol polyprotein inhibitor AC1LA4ZN family 1 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor methyl ... 6 2
Angiotensin-converting enzyme and Histone-lysine N-methyltrans... 1 19
Chymase and Chymotrypsinogen B inhibitor AGN-PC-075LTI family 2 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Angiotensin-converting enzyme inhibitor 89177-63-9 family 2 0
Angiotensin-converting enzyme and Neprilysin inhibitor (5R,7S)... 1 0
Histone deacetylase 1 and Histone deacetylase 8 inhibitor meth... 1 3
Angiotensin-converting enzyme inhibitor SureCN7263641 family 2 11
Angiotensin-converting enzyme and Leukotriene A-4 hydrolase in... 7 1
Neprilysin and Angiotensin-converting enzyme inhibitor 3-[(3S)... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 6
Neprilysin inhibitor AGN-PC-02K4O6 family 2 0
Neprilysin inhibitor methyl (2S)-4-methyl-2-[[2-(sulfanylmethy... 3 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 1 5
Ribonucleoside-diphosphate reductase large subunit and Ribonuc... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Group VII phospholipase A2 and Group 10 secretory phospholipas... 3 0
Gamma-secretase subunit PEN-2 inhibitor SureCN5966881 family 1 9
Angiotensin-converting enzyme inhibitor N-cyclohexylcyclohexan... 2 0
Histone deacetylase 8 and Histone deacetylase 1 inhibitor tert... 1 0
Matrix metalloproteinase-9 and Metalloproteinase inhibitor 3 i... 6 4
Leukotriene A-4 hydrolase and Angiotensin-converting enzyme in... 1 0
4'-phosphopantetheinyl transferase ffp and Beta-lactamase inhi... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor 6-[4-[(2S)-2-ca... 1 0
Pol polyprotein inhibitor methyl (2S)-2-[[(2S)-2-[[(2S)-2-[5-[... 1 2
Gag-Pro polyprotein inhibitor (4S)-3-[(2S,3S)-3-[[(2S,3S)-2-[[... 4 0
Neprilysin and Angiotensin-converting enzyme 2 inhibitor AGN-P... 1 1
Tubulin beta-1 chain inhibitor SureCN6672529 family 1 0
Kinesin-like protein KIF11 inhibitor methyl (2S)-2-[[(2R)-2-am... 1 1
Transcriptional activator protein LuxR inhibitor 3-(3-iodophen... 8 2
Leukotriene A-4 hydrolase and Angiotensin-converting enzyme in... 1 0
4-methyl-2-[[(E)-3-phenylprop-2-enyl]azaniumyl]pentanoate NP 2... 4 6
(2S)-2-[(3aR,6aS)-2,5-dioxo-3,3a,6,6a-tetrahydro-1H-imidazo[4,... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00187793 CHEMBL147185 Bioactive (7S,10S)-9-oxo-10-(sulfanylmethyl)-8-azabicyclo[10.3.1]hexadeca-1(16),12,14-triene-7-carboxylic acid
CFAMM00187757 CHEMBL11537 Bioactive AGN-PC-024W3M
CFAMM00187763 CHEMBL11297 Bioactive AGN-PC-0745FH
CFAMM00187743 CHEMBL55286 Bioactive 2-[(2-benzyl-5-methyl-3-sulfanylhexanoyl)amino]propanoic acid
CFAMM00187791 CHEMBL275690 Bioactive AGN-PC-0745GQ
CFAMM00187797 CHEMBL298827 Bioactive (2-MERCAPTOMETHYL-3-PHENYL-PROPIONYL)-GLYCINE
CFAMM00187811 CHEMBL165980 Bioactive (2R)-2-[[(2R)-2-benzyl-3-sulfanylpropanoyl]amino]propanoic acid
CFAMM00187796 CHEMBL148840 Bioactive (7S,10R)-9-oxo-10-(sulfanylmethyl)-8-azabicyclo[10.3.1]hexadeca-1(16),12,14-triene-7-carboxylic acid
CFAMM00187725 CHEMBL276008 Bioactive AGN-PC-024W2W
CFAMM00187753 CHEMBL442337 Bioactive D-Leucine, N-[2-(mercaptomethyl)-1-oxo-3-phenylpropyl]-, (R)-
CFAMM00187766 CHEMBL6915 Bioactive 2-[[3-phenyl-2-(sulfanylmethyl)butanoyl]amino]butanoic acid
CFAMM00187809 CHEMBL2052008 Bioactive (2S)-2-[[(2R,3R)-3-phenyl-2-(sulfanylmethyl)butanoyl]amino]propanoic acid
CFAMM00187772 CHEMBL80038 Bioactive (2R)-2-[[(2R)-2-benzyl-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00187788 CHEMBL2110347 Bioactive (2S)-2-[[(2S,3S)-2-benzyl-5-methyl-3-sulfanylhexanoyl]amino]propanoic acid
CFAMM00187724 CHEMBL61512 Bioactive AC1OEMTM
CFAMM00187739 CHEMBL345021 Bioactive 2-[(3S,7R)-7-(2-methylpropyl)-2-oxo-3-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]azepan-1-yl]acetic acid
CFAMM00187769 DNC000685 Investigative Drug Gemopatrilat
CFAMM00187805 DNC001437 Investigative Drug Thiorphan

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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