CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID334
Family Name Glucokinase Inhibitor GKA1 Family
No. of Seeds 2 No. of Other Members 67
Family Centroid CFAMM00187891 Functional Category Investigative Drug with Natural Product
Superfamily Glucokinase Inhibitor GKA1 Superfamily
Class Class 1163

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Multidrug resistance-associated protein 1 Inhibitor Biricodar ... 6 40
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Sodium-dependent noradrenaline transporter Inhibitor Neri Iv F... 6 58
Smoothened homolog Inhibitor LDE225 Family 3 76
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
MO15-related protein kinase Pfmrk Inhibitor WR-289010 Family 2 506
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Reverse transcriptase/RNaseH inhibitor AC1LALKM family 2 19
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Aldo-keto reductase family 1 member B10 and Aldose reductase i... 4 13
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Somatostatin receptor type 5 ligand AGN-PC-088VSK family 2 3
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 17
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Acetylcholinesterase and Cholinesterase inhibitor (2Z)-5-metho... 4 23
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
Growth hormone secretagogue receptor type 1 and Potassium volt... 3 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Motilin receptor ligand SureCN2765637 family 1 1
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL4... 2 3
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 2 2
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 6 1
Histamine H3 receptor ligand AGN-PC-03Z8HB family 3 0
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 2 25
Hydroxycarboxylic acid receptor 2 and Hydroxycarboxylic acid r... 2 3
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 4
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 1 1
Neutrophil elastase and Beta-lactamase inhibitor ST073523 family 1 0
Fibroblast growth factor receptor 1 and Fibroblast growth fact... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00187910 CHEMBL1210143 Bioactive SureCN2955060
CFAMM00187891 DNC000691 Investigative Drug GKA1

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27433 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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