CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3342
Family Name Sodium-dependent serotonin transporter Inhibitor 6-nitroquipazine Family
No. of Seeds 18 No. of Other Members 21
Family Centroid CFAMM00289092 Functional Category Investigative Drug
Superfamily cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Histamine H3 receptor Binder Superfamily
Class Class 903

Cousin Family NamesSeedsMembers
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Transient receptor potential cation channel subfamily V member... 15 457
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... 7 11
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 22
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A1 and Adenosine receptor A2a Ligand 3-benz... 1 6
Adenosine receptor A3 Ligand 2-(4-nitro-1h-benzo[d]imidazol-2-... 2 12
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-amin... 2 30
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 1-(3-... 2 29
Aromatase Inhibitor NSC-356781 Family 3 10
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 9 24
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Urotensin-2 receptor Ligand Palosuran Family 4 4
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Amine oxidase [flavin-containing] A Inhibitor 3-benzyl-n-(2-mo... 2 3
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
5-hydroxytryptamine receptor 3A and D(2) dopamine receptor Lig... 1 0
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 11
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 8
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
Bloom syndrome protein inhibitor SR 57227A family 2 12
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Histamine H4 receptor ligand 4-[(3R)-3-(methylamino)pyrrolidin... 7 6
Corticotropin-releasing factor receptor 1 ligand 5-(2,4-dichlo... 5 17
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Transient receptor potential cation channel subfamily V member... 4 0
Scavenger receptor class B member 1 ligand 9-[3-(4,6-diethylpy... 2 0
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
Dihydrofolate reductase inhibitor 5-[4-[(3,4-dichlorophenyl)me... 1 0
Type-1 angiotensin II receptor ligand SureCN7390271 family 2 1
Dihydrofolate reductase type 1 and Dihydrofolate reductase inh... 1 0
Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... 7 2
Corticotropin-releasing factor receptor 1 ligand 5-N,5-N-bis(c... 2 0
ATP-binding cassette sub-family G member 2 and cGMP-specific 3... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00289063 CHEMBL91817 Bioactive 139593-11-6
CFAMM00289080 CHEMBL166280 Bioactive Quinoline, 3-(3-fluoropropyl)-6-nitro-2-(1-piperazinyl)-
CFAMM00289062 CHEMBL88320 Bioactive 2-(2-methylpiperazin-1-yl)-6-nitroquinoline
CFAMM00289050 CHEMBL39265 Bioactive AGN-PC-073MEH
CFAMM00289091 CHEMBL121952 Bioactive 5-methyl-6-nitro-2-piperazin-1-ylquinoline
CFAMM00289042 DNC011409 Investigative Drug 4-Chloro-6-nitro-2-piperazin-1-yl-quinoline
CFAMM00289079 DNC012150 Investigative Drug 6,8-Dinitro-2-piperazin-1-yl-quinoline
CFAMM00289086 DNC011419 Investigative Drug 6-Nitro-4-phenyl-2-piperazin-1-yl-quinoline
CFAMM00289078 DNC012151 Investigative Drug N*1*-(6-Nitro-quinolin-2-yl)-ethane-1,2-diamine
CFAMM00289092 DNC011388 Investigative Drug 6-nitroquipazine
CFAMM00289068 DNC012134 Investigative Drug 3-Bromo-6-nitro-2-piperazin-1-yl-quinoline
CFAMM00289084 DNC012145 Investigative Drug 2-(3-Methyl-piperazin-1-yl)-6-nitro-quinoline
CFAMM00289047 DNC011407 Investigative Drug 4-Benzyl-6-nitro-2-piperazin-1-yl-quinoline
CFAMM00289046 DNC011401 Investigative Drug 4-Bromo-6-nitro-2-piperazin-1-yl-quinoline
CFAMM00289058 DNC011423 Investigative Drug 6-Nitro-2-piperazin-1-yl-4-vinyl-quinoline
CFAMM00289054 DNC012187 Investigative Drug 2-[1,4]Diazepan-1-yl-6-nitro-quinoline
CFAMM00289090 DNC011417 Investigative Drug 4-Iodo-6-nitro-2-piperazin-1-yl-quinoline
CFAMM00289053 DNC011394 Investigative Drug 4-Allyl-6-nitro-2-piperazin-1-yl-quinoline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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