CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3352
Family Name Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapol Family
No. of Seeds 3 No. of Other Members 41
Family Centroid CFAMM00289207 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily Cytochrome P450 11B1, mitochondrial and Potassium voltage-gated channel subfamily A member 5 Binder Superfamily
Class Class 387

Cousin Family NamesSeedsMembers
Thromboxane A2 receptor Ligand Ridogrel Family 7 83
Farnesyl pyrophosphate synthase Inhibitor Risedronate Family 4 28
Histamine H1 receptor Ligand Doxylamine Family 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Citric Acid family 2 58
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 5 23
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 12 3
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
Oestrogen receptor and Estrogen receptor beta Ligand Estrogen ... 7 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Estradiol 17-beta-dehydrogenase 1 Inhibitor 3,3'-pyrazine-2,5-... 2 14
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 5 69
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase inhibit... 2 24
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [(4S,... 5 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 5 8
Sodium-dependent serotonin transporter and Substance-P recepto... 1 0
Platelet-activating factor receptor ligand SureCN9852997 family 1 1
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 5
Nociceptin receptor and Potassium voltage-gated channel subfam... 3 9
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1,1,1... 12 3
Beta-3 adrenergic receptor ligand N-[4-[2-[[(2R)-2-hydroxy-2-p... 4 10
Melanin-concentrating hormone receptor 1 and Potassium voltage... 7 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
Glutamate receptor ionotropic, NMDA 2B ligand SureCN8345160 fa... 1 2
Nuclear receptor ROR-gamma and Induced myeloid leukemia cell d... 1 1
D(2) dopamine receptor and D(3) dopamine receptor ligand [(7S)... 1 3
Urokinase-type plasminogen activator and Plasminogen inhibitor... 1 0
Acetylcholine-binding protein and Neuronal acetylcholine recep... 1 5
Aromatase inhibitor AGN-PC-075MRV family 1 3
Platelet-activating factor receptor ligand 3-[3-[(2S,5R)-5-(4-... 2 4
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 1 0
Pyridines and Derivatives Metabolite 4-Hydroxy-4-(3-pyridyl)-b... 1 2
Pyridines and Derivatives Metabolite Venoterpine Family 1 0
(E)-3-(2-hydroxyphenyl)-1-pyridin-4-ylprop-2-en-1-one NP (e)-3... 1 0
6-pyridin-3-ylpyran-2-one NP 6-(pyridin-3-yl)-2h-pyran-2-one F... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00289207 DNC011452 Investigative Drug METYRAPOL
CFAMM00289200 DNC011431 Investigative Drug 2-Methyl-1,2-di-pyridin-3-yl-1-methoxypropane
CFAMM00289198 DNC011490 Investigative Drug 2-Methyl-1-phenyl-2-pyridin-3-yl-propan-1-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26400 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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