CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3364
Family Name Sodium-dependent dopamine transporter and Sodium-dependent noradrenaline transporter Inhibitor 2-(2,3-dihydro-1h-indol-5-yl)-1-methyl-ethylamine Family
No. of Seeds 6 No. of Other Members 42
Family Centroid CFAMM00289602 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine receptor 3A Binder Superfamily
Class Class 967

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Calmodulin Inhibitor Aprindine Family 1 4
Histamine H1 receptor Ligand Antazoline Family 5 57
D(2) dopamine receptor Ligand Nomifensine Family 6 100
Motilin receptor Ligand GSK962040 Family 30 457
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
WAY-162545 family 2 4
5-hydroxytryptamine receptor 6 Ligand 4-(1h-inden-1-ylmethyl)-... 5 99
Potassium voltage-gated channel subfamily A member 3 Ligand CP... 4 26
5-hydroxytryptamine receptor 5A Ligand N,4-dimethyl-3,4-dihydr... 8 51
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 14 78
Androgen receptor Ligand LG-121071 Family 8 32
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 1,3,... 3 4
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
5-hydroxytryptamine receptor 6 Ligand [2-(3h-indol-1-yl)-ethyl... 2 7
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 8 32
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Aromatase Inhibitor 3-amino-4'-amino-trans-stilbene Family 5 47
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 7 134
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 2 9
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
Histamine H3 receptor Ligand (r)-1-(4-nitrophenethyl)-2-methyl... 16 38
Cholinesterase Inhibitor (-)-debromoflustramine B Family 2 14
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Sphingosine kinase 2 Inhibitor (r)-2-amino-3-(4-octylphenylami... 1 16
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Amine oxidase [flavin-containing] B Inhibitor L-136662 Family 3 20
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 2 7
Nitric oxide synthase, brain Inhibitor N*1*-(5-methyl-2-nitro-... 1 19
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 45
Acetylcholinesterase Inhibitor (3-hydroxy-2-methyl-phenyl)-tri... 4 25
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 9h-bet... 1 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 10
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
5-hydroxytryptamine receptor 2A ligand AGN-PC-075LXD family 4 4
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 0
Sigma non-opioid intracellular receptor 1 ligand 1-[4-[1-adama... 4 23
5-hydroxytryptamine receptor 7 ligand 1-[2-(4-nitrophenyl)phen... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-[[4... 7 11
Substance-P receptor ligand (2R,3R)-2-benzhydryl-N-(2-iodophen... 2 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand 4-[(... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Androgen receptor ligand 4-[(1R,5R)-3-hydroxy-3-methyl-8-azabi... 8 7
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 1 0
Histamine H3 receptor ligand SureCN3052824 family 4 14
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 4
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 4
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 3
Squalene monooxygenase inhibitor 3-[[[(E)-6,6-dimethylhept-2-e... 1 0
Cholinesterase inhibitor 10-[[(1R,9aR)-2,3,4,6,7,8,9,9a-octahy... 1 0
Androgen receptor ligand 1-[4-[3-[4-[(3,3-dimethyl-2-oxobutyl)... 1 2
C-C chemokine receptor type 3 ligand CHEMBL300905 family 2 1
Cytochrome P450 2C9 and Cytochrome P450 2D6 inhibitor N'-(4-he... 1 0
Alkaloids and Derivatives Metabolite (+)-Aspidospermidine Family 1 5
3,3,5,5-tetramethyl-N-phenyl-1,2,4,6,7,8-hexahydronaphthalen-2... 2 0
2,8-dimethyl-1,2,3,4,4a,9b-hexahydropyrido[4,3-b]indol-2-ium-5... 4 1
3,3,5,5,7,10c-hexamethyl-1,2,3,5,5a,6,10b,10c-octahydrocyclope... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00289577 DNC011525 Investigative Drug 1-(2,3-Dihydro-1H-indol-5-ylmethyl)-propylamine
CFAMM00289602 DNC011510 Investigative Drug 2-(2,3-Dihydro-1H-indol-5-yl)-1-methyl-ethylamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543