CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3365
Family Name Reverse transcriptase Inhibitor Atevirdine Family
No. of Seeds 4 No. of Other Members 55
Family Centroid CFAMM00289641 Functional Category Investigative Drug with Natural Product
Superfamily Reverse transcriptase Inhibitor Atevirdine Superfamily
Class Class 227

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
Epidermal Growth Factor family 111 209
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
DCC-2036 family 2 5
Smoothened homolog Inhibitor LDE225 Family 3 76
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
MK-6096 family 3 69
Eluxadoline family 4 85
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Renin Inhibitor Enalkiren Family 56 44
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 1 8
5-hydroxytryptamine receptor 3A and Alpha-2A adrenergic recept... 31 24
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Integrin beta-3 Inhibitor L-756568 Family 8 59
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Alpha-1A adrenergic receptor Ligand A-131701 Family 16 17
Vascular endothelial growth factor receptor 1 and Vascular end... 4 44
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
Melanin-concentrating hormone receptor 1 Ligand Gnf-pf-2322 Fa... 3 95
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
Potassium voltage-gated channel subfamily H member 2 Ligand (1... 64 70
Reverse transcriptase/RNaseH inhibitor AC1LALKM family 2 19
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 1 6
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Serine/threonine-protein kinase PLK1 and Serine/threonine-prot... 14 42
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
Protein farnesyltransferase subunit beta and Protein farnesylt... 3 0
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Aurora kinase A inhibitor SureCN761545 family 2 2
Aurora kinase A inhibitor SureCN761045 family 2 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Casein kinase I isoform delta and Mitogen-activated protein ki... 3 18
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Histamine H3 receptor ligand SureCN7251693 family 3 1
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Platelet-activating factor receptor ligand SureCN7497229 family 4 2
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Fatty-acid amide hydrolase 1 inhibitor 2-(1,3-dihydroisoindol-... 2 3
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 3 4
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2489170 f... 8 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Adenosine receptor A2b ligand 2-[5-(2,6-dioxo-1,3-dipropyl-7H-... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YLX fa... 3 1
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
DNA gyrase subunit B inhibitor N-ethyl-5-[6-methoxy-5-(2-oxo-3... 3 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Growth hormone secretagogue receptor type 1 ligand SureCN36380... 6 0
Microsomal triglyceride transfer protein large subunit inhibit... 9 0
Mu-type opioid receptor and Mu-type opioid receptor ligand (3S... 6 2
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
Scavenger receptor class B member 1 ligand 5-[9-[3-(4,6-dimeth... 7 3
5-hydroxytryptamine receptor 1D ligand N-[4-[[5-[3-[2-(dimethy... 4 16
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 3 5
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
G-protein coupled bile acid receptor 1 ligand 2-ethyl-6-[3-[4-... 4 6
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Motilin receptor ligand SureCN2765637 family 1 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 0
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Glycogen synthase kinase-3 beta inhibitor 3-imidazo[1,2-a]pyri... 1 1
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Growth hormone secretagogue receptor type 1 ligand N-[(1R)-2-(... 3 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Bifunctional epoxide hydrolase 2 inhibitor 8-(quinoline-5-carb... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 8 13
Platelet-activating factor receptor ligand N,N-dimethyl-6-phen... 12 18
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Substance-P receptor ligand N-[(2R)-1-[acetyl-[(2-chlorophenyl... 2 2
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Substance-P receptor ligand SureCN2139814 family 7 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 16 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 0
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
5-hydroxytryptamine receptor 6 ligand 2-[(2Z)-2-[3-[(3-methoxy... 1 11
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 1 3
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
RAF proto-oncogene serine/threonine-protein kinase inhibitor a... 8 6
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Platelet-activating factor receptor ligand AGN-PC-00GDIY family 1 1
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Adenosine receptor A2b and Adenosine receptor A1 ligand [4-(2,... 6 15
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 1 0
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 1 3
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... 2 1
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 2 25
Bromodomain-containing protein 4 and Bromodomain-containing pr... 3 10
Multidrug resistance-associated protein 1 inhibitor SureCN6823... 1 0
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6
Platelet-derived growth factor receptor beta and Vascular endo... 1 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 0
NP 3-(4-isopropoxyphenyl)-n-(2-(5-methoxy-1h-indol-3-yl)ethyl)... 5 0
NP N-(1-((3-(1h-imidazol-1-yl)propyl)amino)-3-methyl-1-oxobuta... 2 0
3-[(2-carbamoylphenoxy)methyl]-N-[2-(1H-indol-3-yl)ethyl]-1,2,... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00289616 CHEMBL1910384 Bioactive 1H-indol-2-yl-[(3S)-3-[2-[(4-methoxyphenyl)methyl-pyridin-2-ylamino]ethylamino]pyrrolidin-1-yl]methanone
CFAMM00289615 CHEMBL1910381 Bioactive 1H-indol-2-yl-[4-[2-[2-[(4-methoxyphenyl)methyl-pyridin-2-ylamino]ethyl-methylamino]ethyl]piperazin-1-yl]methanone
CFAMM00289641 DNC011520 Investigative Drug ATEVIRDINE
CFAMM00289633 DNC011637 Investigative Drug ATEVIRDINE SULPHATE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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