CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3370
Family Name D(2) dopamine receptor Ligand PD-135146 Family
No. of Seeds 5 No. of Other Members 11
Family Centroid CFAMM00289737 Functional Category Investigative Drug with Human Metabolite
Superfamily D(2) dopamine receptor and Interleukin-1 receptor type 1 Binder Superfamily
Class Class 914

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
Transient receptor potential cation channel subfamily V member... 16 295
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Cyclin-dependent kinase 2 Inhibitor 4-(2,4-dimethyl-thiazol-5-... 2 14
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cytochrome P450 3A4 Inhibitor 3-(3-methylthiophen-2-yl)pyridin... 5 27
Metabotropic glutamate receptor 5 Ligand 2-methyl-4-(pyridin-3... 10 35
Vascular endothelial growth factor receptor 2 Ligand 3-(4-amin... 2 5
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Transient receptor potential cation channel subfamily V member... 2 26
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 3 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2
Reverse transcriptase Inhibitor HI-443 Family 1 0
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 2 7
Potassium voltage-gated channel subfamily H member 2 and Neuro... 2 3
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... 1 2
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Platelet-activating factor receptor ligand Foropafant family 2 0
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Vascular endothelial growth factor receptor 2 ligand AC1NS6KN ... 4 5
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Adenosine receptor A1 ligand SureCN1497799 family 2 2
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 5 1
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Metabotropic glutamate receptor 5 ligand AGN-PC-075XWO family 2 0
Glutamate racemase inhibitor (5Z)-N-methyl-5-pyrrol-3-ylidene-... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00289731 CHEMBL1411979 Bioactive methapyrilene
CFAMM00289722 DNC011596 Investigative Drug PD-135188
CFAMM00289737 DNC011554 Investigative Drug PD-135146
CFAMM00289721 DNC011599 Investigative Drug PD-135111

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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