CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3379
Family Name 5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-containing] A Ligand 5-bromo-2,3,4,9-tetrahydro-1h-beta-carboline Family
No. of Seeds 10 No. of Other Members 18
Family Centroid CFAMM00289922 Functional Category Investigative Drug with Natural Product
Superfamily Dihydroorotate dehydrogenase and 5-hydroxytryptamine receptor 2A Binder Superfamily
Class Class 59

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Acetylcholinesterase Inhibitor Tacrine Family 12 515
D(2) dopamine receptor Ligand Sertindole Family 3 173
Gamma-aminobutyric acid A receptor Ligand Bromazepam Family 2 60
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 6 17
Dihydroorotate dehydrogenase Inhibitor Nsc 665564 Family 2 83
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 5 Inhibi... 2 5
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 43 17
Mast/stem cell growth factor receptor Kit Ligand 9-bromo-5,11-... 1 0
Indoleamine 2,3-dioxygenase 1 Inhibitor N-[2-(indol-3-yl)ethyl... 2 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Kinesin-like protein KIF11 Inhibitor 2-(trifluoromethyl)-9h-ca... 5 0
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 7,12-d... 1 0
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Arachidonate 15-lipoxygenase Inhibitor PD-146176 Family 1 3
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
Histone deacetylase Inhibitor ST-5732 Family 8 6
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Progesterone receptor and Androgen receptor ligand 5-[4-[(Z)-C... 2 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Sodium-dependent serotonin transporter inhibitor SureCN6087152... 1 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 4 0
D(4) dopamine receptor and D(1A) dopamine receptor ligand 2-[[... 5 4
Prostaglandin G/H synthase 2 inhibitor SureCN6998947 family 1 1
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 4
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 5 6
Melanin-concentrating hormone receptor 2 ligand N-[(1R)-1'-(9H... 4 1
Melanin-concentrating hormone receptor 2 and Sodium-dependent ... 2 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-6-br... 5 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN5551829 f... 1 14
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-methylsulfany... 1 1
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 2 2
C-X-C chemokine receptor type 2 ligand 1-(benzenesulfonyl)-3-[... 1 2
5-hydroxytryptamine receptor 5A and 5-hydroxytryptamine recept... 2 0
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
CGMP-dependent protein kinase inhibitor AGN-PC-075INU family 1 1
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 1 0
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 5
Prostaglandin G/H synthase 2 inhibitor AGN-PC-03NCPN family 4 0
Prostaglandin G/H synthase 2 inhibitor SureCN6345015 family 6 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 1
Potassium voltage-gated channel subfamily A member 5 and Volta... 2 4
Hexokinase and Farnesyl pyrophosphate synthase inhibitor AC1NQ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00289914 CHEMBL353389 Bioactive 3-[2-(3-bromophenyl)-1H-indol-3-yl]-N,N-dimethylpropan-1-amine
CFAMM00289926 DNC011699 Investigative Drug 8-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline
CFAMM00289938 DNC011672 Investigative Drug 5-Bromo-4,9-dihydro-3H-beta-carboline
CFAMM00289923 DNC011624 Investigative Drug 6-Bromo-4,9-dihydro-3H-beta-carboline
CFAMM00289929 DNC011688 Investigative Drug 7-Bromo-4,9-dihydro-3H-beta-carboline
CFAMM00289922 DNC011647 Investigative Drug 5-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline
CFAMM00289921 DNC011658 Investigative Drug 7-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline
CFAMM00289927 DNC011695 Investigative Drug 8-Bromo-4,9-dihydro-3H-beta-carboline
CFAMM00289920 DNC011657 Investigative Drug 6-Bromo-2,3,4,9-tetrahydro-1H-beta-carboline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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