CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3384
Family Name Protein farnesyltransferase subunit beta Inhibitor A-313326 Family
No. of Seeds 85 No. of Other Members 149
Family Centroid CFAMM00290051 Functional Category Investigative Drug
Superfamily Protein farnesyltransferase subunit beta Inhibitor A-313326 Superfamily
Class Class 2754

Cousin Family NamesSeedsMembers
Type-1 angiotensin II receptor Ligand Telmisartan Family 4 181
Type-1 angiotensin II receptor Ligand Eprosartan Family 36 176
Farnesyltransferase beta subunit, putative Inhibitor Cp-609,75... 2 11
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Histamine H3 receptor Ligand 4-(3-phenoxy-propyl)-1h-imidazole... 26 142
5-hydroxytryptamine receptor 3A and Alpha-2A adrenergic recept... 31 24
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Aromatase Inhibitor 3-((1h-imidazol-1-yl)methyl)-9h-xanthen-9-... 6 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 1-... 2 9
Aromatase Inhibitor 4-((1h-imidazol-1-yl)methyl)-2h-chromen-2-... 3 69
Cytochrome P450 3A4 Inhibitor SK&F-96365 Family 2 26
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor Rac-4'-(1-i... 5 9
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Potassium voltage-gated channel subfamily H member 2 Ligand (1... 64 70
Bombesin receptor subtype-3 ligand AGN-PC-07ZAKV family 13 23
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Cathepsin S and Cathepsin K inhibitor AGN-PC-07YOWS family 4 6
Extracellular calcium-sensing receptor ligand SureCN2972008 fa... 4 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 19 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 8 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 21 0
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 8 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 5 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 1
AMP deaminase 3 inhibitor 4-[2-(8-hydroxy-7,8-dihydro-4H-imida... 1 10
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 3... 5 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 3... 2 10
Calcitonin gene-related peptide type 1 receptor ligand SureCN2... 9 1
Cytochrome P450 26A1 and Cytochrome P450 3A4 inhibitor 3-[6-[(... 14 26
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 5 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 11 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Type-1A angiotensin II receptor ligand 2-[[2-butyl-3-[(4-carbo... 2 4
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 1
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 3
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 2
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 5 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
AMP deaminase 3 and AMP deaminase 1 inhibitor 1-bromo-4-[2-(8-... 1 11
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Serine/threonine-protein kinase Sgk1 inhibitor SureCN3774571 f... 2 18
Glucocorticoid receptor ligand SureCN12238714 family 16 4
Type-1 angiotensin II receptor ligand AGN-PC-025PHO family 3 21
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Alpha-1A adrenergic receptor ligand AGN-PC-0793UT family 3 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00290080 CHEMBL38595 Bioactive SureCN7090668
CFAMM00290140 CHEMBL182679 Bioactive AGN-PC-075DZX
CFAMM00290007 CHEMBL182171 Bioactive AGN-PC-075G4R
CFAMM00290166 CHEMBL24733 Bioactive AGN-PC-074A0T
CFAMM00289987 CHEMBL339230 Bioactive AGN-PC-0753PZ
CFAMM00290059 CHEMBL182812 Bioactive AGN-PC-075DYL
CFAMM00290119 CHEMBL360525 Bioactive SureCN7094457
CFAMM00290132 CHEMBL282161 Bioactive SureCN7049995
CFAMM00290193 CHEMBL183832 Bioactive AGN-PC-075E0K
CFAMM00290013 CHEMBL22703 Bioactive 4-[3-(4-cyanophenyl)-3-hydroxy-3-(3-methylimidazol-4-yl)propyl]-3-(3-methoxyphenyl)benzonitrile
CFAMM00290073 CHEMBL187128 Bioactive AGN-PC-075G2B
CFAMM00290146 CHEMBL182925 Bioactive AGN-PC-075DTG
CFAMM00289966 CHEMBL43631 Bioactive SureCN7574536
CFAMM00289980 CHEMBL183666 Bioactive AGN-PC-075DSK
CFAMM00290026 CHEMBL331224 Bioactive AGN-PC-0753OM
CFAMM00290052 CHEMBL184568 Bioactive AGN-PC-075FZ1
CFAMM00290125 CHEMBL184330 Bioactive AGN-PC-075FZD
CFAMM00290152 CHEMBL158553 Bioactive SureCN5088991
CFAMM00290139 CHEMBL359950 Bioactive AGN-PC-075DYE
CFAMM00290105 CHEMBL38974 Bioactive 6-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-2-naphthalen-2-ylpyridine-3-carbonitrile
CFAMM00290092 CHEMBL25621 Bioactive AGN-PC-074A0V
CFAMM00290058 CHEMBL41454 Bioactive AGN-PC-073MLU
CFAMM00290118 CHEMBL127617 Bioactive 4-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-3-[(E)-2-(4-nitrophenyl)ethenyl]benzonitrile
CFAMM00290131 CHEMBL187254 Bioactive AGN-PC-075G5I
CFAMM00289973 CHEMBL125907 Bioactive 4-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-3-(4-phenylbut-1-ynyl)benzonitrile
CFAMM00290072 CHEMBL181318 Bioactive AGN-PC-075DYX
CFAMM00290098 CHEMBL181442 Bioactive AGN-PC-075G4S
CFAMM00290145 CHEMBL359959 Bioactive 6-[[[4-cyano-3-[2-(trifluoromethyl)phenyl]phenyl]-(3-methylimidazol-4-yl)methoxy]methyl]-2-(4-methylpiperazin-1-yl)pyridine-3-carbonitrile
CFAMM00290158 CHEMBL160562 Bioactive A313326 Analogue 26
CFAMM00289965 CHEMBL41540 Bioactive AGN-PC-073MHX
CFAMM00290124 CHEMBL24048 Bioactive AGN-PC-076IAY
CFAMM00290198 CHEMBL282349 Bioactive AGN-PC-074A1D
CFAMM00290005 CHEMBL183097 Bioactive AGN-PC-075DYC
CFAMM00290177 CHEMBL338853 Bioactive 4-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-3-(3,3-dimethylbut-1-ynyl)benzonitrile
CFAMM00290091 CHEMBL362519 Bioactive AGN-PC-075G2A
CFAMM00290164 CHEMBL338148 Bioactive AGN-PC-0753JU
CFAMM00290191 CHEMBL24271 Bioactive AGN-PC-076IAG
CFAMM00289985 CHEMBL24554 Bioactive AGN-PC-076IC5
CFAMM00289998 CHEMBL182978 Bioactive SureCN7577195
CFAMM00290044 CHEMBL182330 Bioactive 4-[(4-cyanophenyl)methoxy-(3-methylimidazol-4-yl)methyl]-2-(2-formylphenyl)benzonitrile
CFAMM00290057 CHEMBL126270 Bioactive 4-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-3-(4-phenylphenyl)benzonitrile
CFAMM00290071 CHEMBL287729 Bioactive AGN-PC-073MH9
CFAMM00290157 CHEMBL160563 Bioactive A313326 Analogue 25
CFAMM00290011 CHEMBL183719 Bioactive AGN-PC-075DYA
CFAMM00290037 CHEMBL127155 Bioactive 4-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-3-[(1E,3E)-hepta-1,3-dienyl]benzonitrile
CFAMM00290123 CHEMBL186906 Bioactive AGN-PC-075FYM
CFAMM00290063 CHEMBL24822 Bioactive SureCN7568339
CFAMM00289991 CHEMBL183290 Bioactive SureCN7086562
CFAMM00290116 CHEMBL124339 Bioactive AGN-PC-0753OT
CFAMM00290176 CHEMBL184707 Bioactive AGN-PC-075FXX
CFAMM00289984 CHEMBL186617 Bioactive AGN-PC-075G1L
CFAMM00289997 CHEMBL124470 Bioactive AGN-PC-0753OR
CFAMM00290056 CHEMBL332230 Bioactive 4-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-3-(2-phenylethynyl)benzonitrile
CFAMM00290143 CHEMBL124525 Bioactive AGN-PC-0753OS
CFAMM00290156 CHEMBL365289 Bioactive AGN-PC-075G2O
CFAMM00290023 CHEMBL340122 Bioactive AGN-PC-0753OH
CFAMM00289977 CHEMBL187175 Bioactive AGN-PC-075FYA
CFAMM00290149 CHEMBL179902 Bioactive 6-[[[4-cyano-3-[2-(trifluoromethyl)phenyl]phenyl]-(3-methylimidazol-4-yl)methoxy]methyl]-2-morpholin-4-ylpyridine-3-carbonitrile
CFAMM00290162 CHEMBL362881 Bioactive 4-[[3-[(4-cyanophenyl)methyl]imidazol-4-yl]methoxymethyl]-3-[4-(trifluoromethoxy)phenyl]benzonitrile
CFAMM00290042 CHEMBL123687 Bioactive AGN-PC-0753KB
CFAMM00290022 CHEMBL435247 Bioactive SureCN5094183
CFAMM00290082 CHEMBL186641 Bioactive AGN-PC-075G0K
CFAMM00290155 CHEMBL180550 Bioactive AGN-PC-075DTO
CFAMM00290168 CHEMBL123792 Bioactive 4-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-3-[(E)-2-pyridin-2-ylethenyl]benzonitrile
CFAMM00290035 CHEMBL157782 Bioactive AGN-PC-008ZFC
CFAMM00290061 CHEMBL41515 Bioactive AGN-PC-073MH2
CFAMM00290121 CHEMBL43455 Bioactive AGN-PC-006ETE
CFAMM00290135 CHEMBL184537 Bioactive 4-[[3-[(4-cyanophenyl)methyl]imidazol-4-yl]methoxymethyl]-3-naphthalen-2-ylbenzonitrile
CFAMM00289968 CHEMBL418018 Bioactive AGN-PC-076ICA
CFAMM00290041 CHEMBL183276 Bioactive AGN-PC-075DZJ
CFAMM00290068 CHEMBL124081 Bioactive 3-[2-(4-cyanophenyl)ethynyl]-4-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]benzonitrile
CFAMM00290127 CHEMBL24043 Bioactive 4-[3-(4-cyanophenyl)-3-hydroxy-3-(3-methylimidazol-4-yl)prop-1-ynyl]-3-(3-ethoxyphenyl)benzonitrile
CFAMM00290141 CHEMBL399482 Bioactive A313326 Analogue 20
CFAMM00290081 CHEMBL361357 Bioactive AGN-PC-075DYT
CFAMM00290154 CHEMBL127296 Bioactive A313326 Analogue 15
CFAMM00290180 CHEMBL181748 Bioactive AGN-PC-075FZR
CFAMM00289988 CHEMBL182180 Bioactive AGN-PC-075DYG
CFAMM00290060 CHEMBL182810 Bioactive AGN-PC-075G2X
CFAMM00290194 CHEMBL421641 Bioactive 4-[[(4-cyanophenyl)-(3-methylimidazol-4-yl)methoxy]methyl]-3-[2-(3-hydroxyphenyl)ethynyl]benzonitrile
CFAMM00290014 CHEMBL22702 Bioactive 4-[3-(4-cyanophenyl)-3-hydroxy-3-(3-methylimidazol-4-yl)prop-1-ynyl]-3-(3-methoxyphenyl)benzonitrile
CFAMM00290187 CHEMBL23370 Bioactive AGN-PC-076HWY
CFAMM00289967 CHEMBL132283 Bioactive AGN-PC-075KET
CFAMM00290027 CHEMBL156387 Bioactive A313326 Analogue 50
CFAMM00290040 CHEMBL183725 Bioactive SureCN7569543
CFAMM00290051 DNC011640 Investigative Drug A-313326

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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