CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3388
Family Name Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4]oxazepin-11-one Family
No. of Seeds 9 No. of Other Members 60
Family Centroid CFAMM00290308 Functional Category Investigative Drug with Natural Product
Superfamily Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4]oxazepin-11-one Superfamily
Class Class 1677

Cousin Family NamesSeedsMembers
SUR1-type K(ATP) channel and SUR2-type K(ATP) channel Ligand R... 1 16
D(2) dopamine receptor Ligand Nemonapride Family 70 283
Beta-1 adrenergic receptor Ligand Acebutolol Family 2 27
Sodium channel protein type 5 subunit alpha Ligand Proparacain... 2 26
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Histamine H1 receptor Ligand Tranilast Family 5 125
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
D(4) dopamine receptor Ligand PD-165167 Family 2 96
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
Cinitapride family 4 22
Dihydroorotate dehydrogenase and Interleukin-17A Inhibitor Vid... 4 74
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Neuropeptide Y receptor type 1 Ligand BMS-193885 Family 3 11
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Amine oxidase [flavin-containing] A Inhibitor Ethyl 4-(2-oxo-2... 4 117
Tubulin Inhibitor WR85915 Family 3 15
Sodium channel protein type 10 subunit alpha Ligand A-803467 F... 2 81
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 7 23
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 40 90
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 4-(2... 4 31
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Cytochrome P450 1B1 Inhibitor N-(2,4-dimethoxy-phenyl)-3,5-dim... 1 110
Histamine H3 receptor Ligand A-349821 Family 49 228
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Alpha-1A adrenergic receptor Ligand Naftopidil Family 15 119
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Oxysterols receptor LXR-alpha Ligand N-{4-[2-(4-methoxyphenyl)... 3 16
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Histone deacetylase 2 Inhibitor N-(4-amino-3'-methoxybiphenyl-... 3 49
Leukotriene A-4 hydrolase Inhibitor N5-[4-(2-oxo-3-phenylpropo... 1 61
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Macrophage migration inhibitory factor Inhibitor 3-benzyl-5-me... 10 42
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
Sodium channel protein type 10 subunit alpha and Sodium channe... 2 13
Amine oxidase [flavin-containing] B Inhibitor N-methyl-n-pheny... 6 25
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
D(2) dopamine receptor Ligand Epidepride Family 31 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Aldose reductase Inhibitor (6-hydroxy-2-oxo-2h-quinolin-1-yl)-... 3 4
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 8 39
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
Metabotropic glutamate receptor 5 Ligand N-(3-(3-cyanobenzamid... 2 13
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 2 17
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
D(2) dopamine receptor ligand 7-[4-[4-(2-ethoxyphenyl)piperazi... 12 14
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 9 22
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 3 6
Beta-1 adrenergic receptor ligand 4-[2-[[(2S)-3-(2-cyano-5-flu... 3 2
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 2
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 2 0
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 11 4
Alpha-1A adrenergic receptor and 5-hydroxytryptamine receptor ... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-3... 2 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
D(3) dopamine receptor and D(1A) dopamine receptor ligand N-[(... 6 14
Microsomal triglyceride transfer protein large subunit inhibit... 4 5
D(3) dopamine receptor and D(2) dopamine receptor ligand (E)-N... 2 2
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-01ZLS4 family 2 8
Neuropeptide S receptor and Prelamin-A/C ligand CHEMBL1352632 ... 1 25
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 1
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
Nuclear receptor ROR-gamma and Menin ligand CHEMBL1432265 family 1 18
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 2
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 4 4
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 7 4
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 5 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
Prelamin-A/C and Cruzipain inhibitor CHEMBL1598118 family 1 3
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 4 2
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 6 11
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QMLE family 5 0
DNA-dependent protein kinase catalytic subunit and Phosphatidy... 1 6
Trace amine-associated receptor 1 ligand EPPTB family 4 9
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Leukotriene A-4 hydrolase inhibitor AGN-PC-0A9QDC family 2 5
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 4 1
Androgen receptor ligand (2R)-2-ethyl-1-(2,2,2-trifluoroethyl)... 32 6
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 5
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 2 4
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 5
Transient receptor potential cation channel subfamily V member... 1 0
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
MAP kinase-activated protein kinase 2 inhibitor 5-(4-cyanophen... 3 8
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 2 0
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Cathepsin S and Cathepsin K inhibitor arylaminoethyl amide, 7 ... 2 0
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Sodium-dependent serotonin transporter inhibitor 2-[2-[(dimeth... 3 3
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 0
Translocator protein inhibitor AGN-PC-00CH84 family 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Translocator protein inhibitor [11C]DAA1106 family 15 2
Microsomal triglyceride transfer protein large subunit inhibit... 3 0
Translocator protein inhibitor N-methyl-2-[2-oxo-5-[4-(trifluo... 9 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Motilin receptor ligand SureCN14564469 family 1 6
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand CHEMB... 6 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 2 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Receptor-type tyrosine-protein kinase FLT3 ligand (3Z)-5-chlor... 1 4
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 6 11
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 10
Bifunctional epoxide hydrolase 2 and RAF proto-oncogene serine... 4 10
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 5
Glutamate receptor ionotropic, NMDA 2B and Potassium voltage-g... 2 1
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 10 2
Progesterone receptor ligand CHEMBL252850 family 2 0
5-hydroxytryptamine receptor 1A ligand SureCN10513645 family 9 1
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 11
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
D(3) dopamine receptor and D(4) dopamine receptor ligand SureC... 3 19
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 1
5-hydroxytryptamine receptor 1A ligand 3-hydroxy-6-iodo-2-[2-[... 2 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 10
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 4 4
Pol polyprotein inhibitor AC1LALH8 family 2 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Mu-type opioid receptor ligand AGN-PC-00NCMO family 3 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 2
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Pol polyprotein inhibitor AC1LA3B0 family 1 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-00RZQT family 3 4
Beta-3 adrenergic receptor ligand 4-[4-[2-[[(2R)-2-(4-aminophe... 3 0
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJY family 5 4
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KFD family 1 1
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
Growth hormone secretagogue receptor type 1 ligand N-[4-[(2S)-... 1 0
Hormone-sensitive lipase inhibitor [4-[(4-tert-butylcyclohexan... 2 1
Vasopressin V2 receptor ligand SureCN4206215 family 1 2
Lanosterol synthase inhibitor AGN-PC-07BZTC family 1 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 12
5-hydroxytryptamine receptor 7 and 5-hydroxytryptamine recepto... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 1 0
Cathepsin E and Cathepsin D inhibitor SureCN2529506 family 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 1 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 9
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 2
Mitogen-activated protein kinase 14 inhibitor AGN-PC-00A4QT fa... 2 0
Pol polyprotein inhibitor Phenprocoumon .b.AlaNH deriv. family 1 5
Leukotriene B4 receptor 1 ligand 4-methoxy-3-[[(E)-3-(4-phenyl... 2 10
Histone deacetylase 8 and Histone deacetylase 6 inhibitor (3S)... 4 16
Amine oxidase [flavin-containing] B and Adenosine receptor A2b... 2 2
Follicle-stimulating hormone receptor ligand (1-acetyl-2,2,4-t... 1 2
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 0
Caspase-3 inhibitor AGN-PC-00ELYM family 3 2
Dual specificity mitogen-activated protein kinase kinase 1 inh... 3 0
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 2 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 0
Cathepsin K inhibitor N-[2-(4-methoxyanilino)ethyl]-4-methyl-2... 1 1
Histone deacetylase 1 and Histone deacetylase 2 inhibitor Sure... 2 0
Cyclin-dependent kinase 4 inhibitor SureCN3563106 family 1 1
Thioredoxin glutathione reductase and Microtubule-associated p... 1 2
Huntingtin and Retinal dehydrogenase 1 inhibitor CHEMBL1467512... 1 0
Acetylcholinesterase inhibitor 4-[(2-methoxyanilino)methyl]-[1... 2 4
Hypoxia-inducible factor 1-alpha inhibitor 2-morpholin-4-yleth... 2 0
Malate dehydrogenase, mitochondrial and Lactate dehydrogenase ... 1 1
Multidrug resistance protein 1 inhibitor (1R)-2-[4-(2-methoxyp... 2 0
Sodium channel protein type 1 subunit alpha and Sodium channel... 3 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
D(1A) dopamine receptor and D(3) dopamine receptor ligand 7-[3... 1 12
NP (s)-3-(2,5-dioxo-2,3,4,5-tetrahydro-1h-benzo[e][1,4]diazepi... 3 0
4-(4-methoxyphenyl)-2,4,5,10-tetrahydro-1H-pyrrolo[3,4-c][1,5]... 4 0
Putative NP ZINC17112928 Family 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00290274 CHEMBL64702 Bioactive AGN-PC-00GCWQ
CFAMM00290288 CHEMBL253596 Bioactive methyl 2-[(N-acetyl-2-phenoxyanilino)methyl]benzoate
CFAMM00290309 DNC011702 Investigative Drug 10-Ethyl-10H-dibenzo[b,f][1,4]oxazepin-11-one
CFAMM00290308 DNC011701 Investigative Drug 10-Propyl-10H-dibenzo[b,f][1,4]oxazepin-11-one
CFAMM00290255 DNC011662 Investigative Drug 10-Allyl-10H-dibenzo[b,f][1,4]oxazepin-11-one
CFAMM00290310 DNC011709 Investigative Drug 10-Isopropyl-10H-dibenzo[b,f][1,4]oxazepin-11-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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