CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID339
Family Name 5-hydroxytryptamine receptor 1B Ligand GR55562 Family
No. of Seeds 3 No. of Other Members 45
Family Centroid CFAMM00188088 Functional Category Investigative Drug with Natural Product
Superfamily 5-hydroxytryptamine receptor 1B Ligand GR55562 Superfamily
Class Class 1542

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Cannabinoid receptor 1 Ligand Taranabant Family 20 30
Histamine H3 receptor Ligand GSK239512 Family 2 65
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor GSK2... 15 18
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Coagulation factor X Inhibitor Otamixaban Family 9 21
Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619... 3 61
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Smoothened homolog Inhibitor LDE225 Family 3 76
Eluxadoline family 4 85
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Reverse transcriptase Inhibitor 3'thiacytidine Family 4 29
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Putative histidine protein kinase Inhibitor Closantel 6 Family 1 2
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
5-hydroxytryptamine receptor 1A Ligand Sun N4057 Family 2 86
Estradiol 17-beta-dehydrogenase 1 Inhibitor 4'-(6-methoxypyrid... 5 34
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 6
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-methoxyphenyl)qu... 2 11
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Renin Inhibitor CP-305202 Family 9 30
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Beta-ketoacyl-acyl carrier protein synthase III Inhibitor 2-[3... 1 2
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
C-C chemokine receptor type 5 ligand (2,4-dimethyl-1-oxidopyri... 5 4
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
Gonadotropin-releasing hormone receptor ligand 1-[(2,6-difluor... 6 31
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
cAMP-dependent protein kinase type II-alpha regulatory subunit... 2 4
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Neuronal acetylcholine receptor subunit beta-4 and Neuronal ac... 1 0
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 13 0
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Vascular endothelial growth factor receptor 2 ligand AGN-PC-05... 2 2
Sodium channel protein type 10 subunit alpha and Sodium channe... 3 22
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Disintegrin and metalloproteinase domain-containing protein 17... 2 5
B2 bradykinin receptor ligand SureCN6640854 family 7 4
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Cathepsin S and Cathepsin K inhibitor N-[(2S)-3-(1-methylcyclo... 2 0
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
Histamine H3 receptor ligand SureCN2784306 family 5 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor Sure... 14 8
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Metabotropic glutamate receptor 2 and Metabotropic glutamate r... 3 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Prothrombin inhibitor AGN-PC-073H0Z family 9 6
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 2 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Histone deacetylase inhibitor (3S,6S,9S,12R)-3-[(2S)-butan-2-y... 1 0
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... 3 0
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 14
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Retinoic acid receptor RXR-alpha ligand (E)-3-[3-(3,5-ditert-b... 5 5
Histamine H3 receptor ligand 3-[4-[3-[(2R)-2-methylpyrrolidin-... 1 5
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 11
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 1
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 1 13
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 2
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 3 1
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Beta-3 adrenergic receptor ligand 6-[4-[2-[[(2S)-3-[(3,3-dimet... 6 7
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Platelet-derived growth factor receptor beta and Macrophage co... 1 4
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Histamine H3 receptor ligand 6-[[2-[2-[(2R)-2-methylpyrrolidin... 2 0
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 3 1
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
Melanin-concentrating hormone receptor 1 ligand 3-[6-[3-(dimet... 14 6
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoylpyrrol-1... 4 6
D(4) dopamine receptor ligand AGN-PC-00SXAZ family 2 4
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Hydroxycarboxylic acid receptor 2 and Cytochrome P450 2C9 liga... 2 6
Motilin receptor ligand SureCN2768193 family 2 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 11 7
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Bifunctional epoxide hydrolase 2 inhibitor 8-(quinoline-5-carb... 1 0
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
Prothrombin and Coagulation factor X inhibitor N-[3-[(3-fluoro... 1 8
Egl nine homolog 1 inhibitor 2-(2-methoxy-4-phenylphenyl)-8-[(... 1 0
Transient receptor potential cation channel subfamily V member... 6 1
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... 1 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Platelet-activating factor receptor ligand N,N-dimethyl-6-phen... 12 18
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 1 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 15
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Coagulation factor X and Prothrombin inhibitor SureCN6434488 f... 3 13
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Pol polyprotein inhibitor Tertiary Amide deriv. 58 family 1 0
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
CGMP-dependent protein kinase inhibitor AGN-PC-075IHL family 2 8
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 12
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 2 2
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
Renin inhibitor SureCN7300793 family 2 5
Sodium-dependent serotonin transporter and Neuropeptide Y rece... 1 0
5-hydroxytryptamine receptor 4 ligand 4-amino-5-chloro-N-[1-[8... 2 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 4
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 3
Hydroxycarboxylic acid receptor 2 ligand AGN-PC-04RSPS family 4 0
Platelet-activating factor receptor ligand [(2R,4R)-4-(octadec... 3 2
Leucyl-cystinyl aminopeptidase inhibitor SureCN988709 family 1 14
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 2 10
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 2 7
Sodium channel protein type 9 subunit alpha and Sodium channel... 1 1
Tyrosine-protein kinase JAK3 and Activated CDC42 kinase 1 inhi... 4 1
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 3
Rho-associated protein kinase 1 and Casein kinase I isoform ga... 1 1
Cytochrome P450 1A2 and Metabotropic glutamate receptor 4 liga... 1 2
Thromboxane-A synthase and Platelet-activating factor receptor... 1 6
Bile acid receptor ligand SureCN1243717 family 1 4
Fatty-acid amide hydrolase 1 and Monoglyceride lipase inhibito... 1 3
Platelet-derived growth factor receptor beta and Vascular endo... 1 3
Platelet-activating factor receptor ligand AGN-PC-001U4L family 2 0
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 2 0
NP N-(2-(3,4-dimethoxyphenyl)-4-oxo-4h-chromen-6-yl)nicotinami... 6 1
NP N-(2-(2-methoxyphenyl)-4-oxo-4h-chromen-6-yl)nicotinamide F... 9 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00188042 CHEMBL67692 Bioactive 4-[4-[[(E)-3-[3-(diaminomethylidene)-6-oxocyclohexa-1,4-dien-1-yl]prop-2-enyl]carbamoyl]phenyl]pyridine-2-carboxamide
CFAMM00188088 DNC000704 Investigative Drug GR55562

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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