CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3412
Family Name Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-bromo-phenyl)-chromen-4-one Family
No. of Seeds 6 No. of Other Members 21
Family Centroid CFAMM00290866 Functional Category Investigative Drug with Natural Product
Superfamily Prostaglandin D2 receptor 2 and Gamma-aminobutyric acid receptor subunit alpha-1 Binder Superfamily
Class Class 2225

Cousin Family NamesSeedsMembers
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Sodium channel protein type 5 subunit alpha Ligand Dyclonine F... 6 174
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Vitamin K-dependent gamma-carboxylase Inhibitor Anisindione Fa... 3 243
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Ipriflavone family 62 2480
Agrimophol family 10 22
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Multidrug resistance-associated protein 1 Inhibitor Benzbromar... 2 16
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Steryl-sulfatase Inhibitor Sulfamic Acid 4-(3-methoxy-benzoyl)... 5 24
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor (2,5... 1 9
Steryl-sulfatase Inhibitor Sulfamic Acid 2-nonyl-4-oxo-4h-chro... 4 68
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 3
4-aminobutyrate aminotransferase, mitochondrial and Succinate-... 4 22
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Prostaglandin D2 receptor 2 Ligand 2-(2-benzoyl-4-bromophenoxy... 4 35
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Interleukin-8 Inhibitor 2-(2-(2-fluorophenoxy)phenyl)acetic Ac... 2 4
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Amine oxidase [flavin-containing] B Inhibitor 8-bromo-6-methyl... 5 44
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Fatty-acid amide hydrolase 1 Inhibitor Benzofuran-2-ylboronic ... 1 14
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 7
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 2 7
Carbonic anhydrase 2 and Carbonic anhydrase 5A, mitochondrial ... 3 2
Sterol 26-hydroxylase, mitochondrial and 1,25-dihydroxyvitamin... 1 2
Solute carrier family 22 member 6 and Histone-lysine N-methylt... 1 1
Squalene--hopene cyclase and Lanosterol synthase inhibitor R17... 1 22
Cholinesterase inhibitor (8R,8aS,10aS)-2-bromo-8-methoxy-9-oxo... 1 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 2 6
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 2 0
Benzofurans Metabolite (R)-Bitalin A Family 1 9
NP 6-(4-ethoxyphenyl)-1,3-dimethyl-4-oxo-4h-cyclohepta[c]furan... 13 3
6-bromo-2-oxo-4-phenyl-3,4-dihydrochromene-3-carboxylate NP ZI... 4 0
(6-bromo-5,8-dioxonaphthalen-1-yl) acetate NP 6-bromo-5,8-diox... 1 1
2,4-dimethyl-5,6-dihydro-4H-furo[2',3':3,4]cyclohepta[1,2-b][1... 9 0
NP 3-(4-methoxyphenoxy)-4-oxo-4h-chromen-7-yl 4-bromobenzoate ... 13 0
[4-(6-bromo-2-oxochromen-3-yl)-2-oxochromen-7-yl]oxyacetate NP... 7 0
NP 3-(6-bromo-4h-benzo[d][1,3]dioxin-8-yl)-4h-chromen-4-one Fa... 2 0
1-benzofuran-3-one NP ZINC09050975 Family 24 0
1-benzofuran-3-one NP ZINC02367988 Family 9 0
Putative NP ZINC02424323 Family 24 0
Putative NP ZINC04898806 Family 3 2
NP 7-[(4-bromobenzyl)oxy]-3-(2-methoxyphenyl)-2-(trifluorometh... 7 0
bromobenzoate NP ZINC11865066 Family 6 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00290841 CHEMBL335086 Bioactive ZINC00950325
CFAMM00290866 DNC011771 Investigative Drug 2-(3-Bromo-phenyl)-chromen-4-one
CFAMM00290846 DNC014715 Investigative Drug 2-(3-Bromo-phenyl)-6-methyl-chromen-4-one
CFAMM00290865 DNC011777 Investigative Drug 6-Bromo-2-(3-bromo-phenyl)-chromen-4-one
CFAMM00290864 DNC011775 Investigative Drug 6-Bromo-2-phenyl-chromen-4-one
CFAMM00290849 DNC013709 Investigative Drug 3-Bromo-2'-hydroxy-4-methoxychalcone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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