CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3420
Family Name 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 1D Ligand 1-(3-trifluoromethyl-phenyl)-piperazine Family
No. of Seeds 5 No. of Other Members 18
Family Centroid CFAMM00290950 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 1D Binder Superfamily
Class Class 2765

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Sodium channel Ligand iminostilbene derivative (tricyclic stru... 2 46
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Serotonin re-uptake inhibitor Dibenzazepine Clomipramine Family 2 23
Calmodulin Inhibitor Aprindine Family 1 4
Histamine H1 receptor Ligand Antazoline Family 5 57
D(2) dopamine receptor Ligand Nomifensine Family 6 100
Motilin receptor Ligand GSK962040 Family 30 457
Tumor necrosis factor Inhibitor Pirfenidone Family 2 38
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
WAY-162545 family 2 4
Potassium voltage-gated channel subfamily A member 3 Ligand CP... 4 26
5-hydroxytryptamine receptor 5A Ligand N,4-dimethyl-3,4-dihydr... 8 51
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 14 78
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 1,3,... 3 4
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
5-hydroxytryptamine receptor 6 Ligand [2-(3h-indol-1-yl)-ethyl... 2 7
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 8 32
Androgen receptor Ligand YM-175735 Family 30 129
Aromatase Inhibitor 3-amino-4'-amino-trans-stilbene Family 5 47
Androgen receptor Ligand 6-n-propyl -4-trifluoromethylquinolin... 29 13
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 7 134
Kinesin-like protein KIF11 Inhibitor N-[4'-(trifluoromethyl)-4... 2 9
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
Histamine H3 receptor Ligand (r)-1-(4-nitrophenethyl)-2-methyl... 16 38
Cholinesterase Inhibitor (-)-debromoflustramine B Family 2 14
Sphingosine kinase 2 Inhibitor (r)-2-amino-3-(4-octylphenylami... 1 16
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 34
Amine oxidase [flavin-containing] B Inhibitor L-136662 Family 3 20
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 1 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 42
Nitric oxide synthase, brain Inhibitor N*1*-(5-methyl-2-nitro-... 1 19
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 45
Acetylcholinesterase Inhibitor (3-hydroxy-2-methyl-phenyl)-tri... 4 25
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 9h-bet... 1 1
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 4 24
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
Tyrosinase Inhibitor 1-hydroxy-3-(4-(trifluoromethyl)phenyl)ur... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 10
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 5 5
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 4
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 7 27
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Sodium-dependent noradrenaline transporter inhibitor 3-[1-(2-f... 2 13
5-hydroxytryptamine receptor 2A ligand AGN-PC-075LXD family 4 4
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 0
Sigma non-opioid intracellular receptor 1 ligand 1-[4-[1-adama... 4 23
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 2 3
Peroxisome proliferator-activated receptor delta ligand (Z)-2-... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1-[(3-nitroph... 4 2
5-hydroxytryptamine receptor 7 ligand 1-[2-(4-nitrophenyl)phen... 1 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-cyclo... 3 4
Substance-P receptor ligand (2R,3R)-2-benzhydryl-N-(2-iodophen... 2 0
Chitin synthase 1 inhibitor AC1O53V7 family 9 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand 4-[(... 2 3
Steroidogenic factor 1 and Nuclear receptor subfamily 5 group ... 1 13
Androgen receptor ligand 4-[(1R,5R)-3-hydroxy-3-methyl-8-azabi... 8 7
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-[2-... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 4
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 3
Lysosomal Pro-X carboxypeptidase and Glutamate receptor ionotr... 1 0
Squalene monooxygenase inhibitor 3-[[[(E)-6,6-dimethylhept-2-e... 1 0
Cholinesterase inhibitor 10-[[(1R,9aR)-2,3,4,6,7,8,9,9a-octahy... 1 0
Androgen receptor ligand 1-[4-[3-[4-[(3,3-dimethyl-2-oxobutyl)... 1 2
C-C chemokine receptor type 3 ligand CHEMBL300905 family 2 1
Cytochrome P450 2C9 and Cytochrome P450 2D6 inhibitor N'-(4-he... 1 0
Alkaloids and Derivatives Metabolite (+)-Aspidospermidine Family 1 5
3,3,5,5-tetramethyl-N-phenyl-1,2,4,6,7,8-hexahydronaphthalen-2... 2 0
2,8-dimethyl-1,2,3,4,4a,9b-hexahydropyrido[4,3-b]indol-2-ium-5... 4 1
3,3,5,5,7,10c-hexamethyl-1,2,3,5,5a,6,10b,10c-octahydrocyclope... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00290967 DNC011916 Investigative Drug 2-Piperazin-1-yl-benzonitrile
CFAMM00290950 DNC011799 Investigative Drug 1-(3-Trifluoromethyl-phenyl)-piperazine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27269 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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