CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3427
Family Name Platelet-derived growth factor receptor alpha and Platelet-derived growth factor receptor beta Ligand 5-methoxy-1-phenyl-1h-benzoimidazole Family
No. of Seeds 3 No. of Other Members 18
Family Centroid CFAMM00291070 Functional Category Investigative Drug with Human Metabolite
Superfamily Platelet-derived growth factor receptor alpha and Platelet-derived growth factor receptor beta Ligand 5-methoxy-1-phenyl-1h-benzoimidazole Superfamily
Class Class 420

Cousin Family NamesSeedsMembers
Potassium-transporting ATPase alpha chain 1 Inhibitor Rabepraz... 4 113
Histamine H1 receptor Ligand Astemizole Family 7 240
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Nitric oxide synthase, inducible Inhibitor 4-(1h-imidazol-1-yl... 1 7
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Oestrogen receptor and Estrogen receptor beta Ligand 4-(2-phen... 2 9
D(4) dopamine receptor Ligand A-425444 Family 2 10
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Indoleamine 2,3-dioxygenase 1 Inhibitor 2-(1h-imidazol-4-yl)be... 2 6
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Platelet-derived growth factor receptor beta and Platelet-deri... 2 19
Survival motor neuron protein inhibitor CHEMBL1379159 family 1 10
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Neuropeptide Y receptor type 1 ligand 1-[3-[1-(cyclohexylmethy... 15 9
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 3
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 3
Cathepsin K and Cathepsin L1 inhibitor CHEBI:43424 family 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 16 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 1 3
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 5 8
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 4 11
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Vascular endothelial growth factor receptor 2 and Vascular end... 4 2
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 11 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Rho-associated protein kinase 1 inhibitor SureCN4716133 family 2 2
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 2
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 2 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 5
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Metabotropic glutamate receptor 2 ligand 2-[[(1R,5S)-6-[(2,5-d... 2 3
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Glutaminyl-peptide cyclotransferase inhibitor 1-(3,4-dimethoxy... 1 17
Cytochrome P450 2C19 and Cytochrome P450 1A2 inhibitor 2-hepty... 4 4
Arachidonate 5-lipoxygenase-activating protein inhibitor 1-[(2... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00291087 DNC011841 Investigative Drug 4-(5-Methoxy-benzoimidazol-1-yl)-phenylamine
CFAMM00291070 DNC011831 Investigative Drug 5-Methoxy-1-phenyl-1H-benzoimidazole
CFAMM00291069 DNC011833 Investigative Drug 1-Phenyl-1H-benzoimidazol-5-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26400 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543