CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3432
Family Name 5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic receptor Ligand RWJ-25730 Family
No. of Seeds 28 No. of Other Members 24
Family Centroid CFAMM00291217 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic receptor Ligand RWJ-25730 Superfamily
Class Class 1145

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Muscarinic acetylcholine receptor M1 Ligand AC-260584 Family 4 36
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Integrin beta-3 Inhibitor L-756568 Family 8 59
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
C-C chemokine receptor type 5 ligand (2,4-dimethyl-1-oxidopyri... 5 4
Cathepsin S inhibitor AGN-PC-07ZCGX family 2 20
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 9 22
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
Histamine H3 receptor ligand (4S)-7-bromo-4-methyl-8-(1-propan... 2 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 3-... 4 8
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 3 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Sonic hedgehog protein inhibitor 3-methoxy-1-methyl-4-oxo-5-ph... 5 3
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Vasopressin V2 receptor ligand SureCN4400636 family 1 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 1 2
Histamine H3 receptor ligand SureCN1397929 family 1 1
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... 58 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00291212 CHEMBL434512 Bioactive SureCN10525334
CFAMM00291218 CHEMBL543905 Bioactive AGN-PC-07C06K
CFAMM00291234 CHEMBL152311 Bioactive 1-[[1-methyl-5-[[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]methyl]pyrrol-2-yl]methyl]azepan-2-one
CFAMM00291197 CHEMBL152363 Bioactive 1-[[5-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-1-methylpyrrol-2-yl]methyl]azepan-2-one
CFAMM00291211 CHEMBL440499 Bioactive AGN-PC-074JRR
CFAMM00291190 CHEMBL1161067 Bioactive AGN-PC-080PLQ
CFAMM00291203 CHEMBL348241 Bioactive 1-[[5-[[4-(2-ethoxyphenyl)piperazin-1-yl]methyl]-1-methylpyrrol-2-yl]methyl]pyrrolidin-2-one
CFAMM00291233 CHEMBL345506 Bioactive 1-[[1-methyl-5-[[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]methyl]pyrrol-2-yl]methyl]pyrrolidin-2-one
CFAMM00291210 CHEMBL346168 Bioactive 1-[[1-methyl-5-[[4-(2-propan-2-yloxyphenyl)piperazin-1-yl]methyl]pyrrol-2-yl]methyl]azocan-2-one
CFAMM00291202 CHEMBL1161065 Bioactive AGN-PC-080PLO
CFAMM00291189 CHEMBL152776 Bioactive SureCN9751111
CFAMM00291195 CHEMBL1161061 Bioactive AGN-PC-080PLK
CFAMM00291209 CHEMBL1161068 Bioactive AGN-PC-080PLR
CFAMM00291222 CHEMBL153136 Bioactive AGN-PC-003ULW
CFAMM00291238 CHEMBL1161052 Bioactive AGN-PC-080PLB
CFAMM00291215 CHEMBL435198 Bioactive N-[[5-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-1-methylpyrrol-2-yl]methyl]-N-propan-2-ylmethanesulfonamide
CFAMM00291194 CHEMBL1161063 Bioactive AGN-PC-080PLM
CFAMM00291237 CHEMBL1161059 Bioactive AGN-PC-080PLI
CFAMM00291200 CHEMBL1161074 Bioactive AGN-PC-080PLX
CFAMM00291214 CHEMBL347056 Bioactive 1-[[5-[[4-(2-methoxyphenyl)piperazin-1-yl]methyl]-1-methylpyrrol-2-yl]methyl]azocan-2-one
CFAMM00291243 CHEMBL1161055 Bioactive AGN-PC-080PLE
CFAMM00291207 CHEMBL76867 Bioactive AGN-PC-074JR4
CFAMM00291193 CHEMBL1161064 Bioactive AGN-PC-080PLN
CFAMM00291236 CHEMBL124285 Bioactive AGN-PC-04VJCL
CFAMM00291199 CHEMBL1161073 Bioactive AGN-PC-080PLW
CFAMM00291192 CHEMBL348002 Bioactive 1-[[5-[[4-(2-butoxyphenyl)piperazin-1-yl]methyl]-1-methylpyrrol-2-yl]methyl]azepan-2-one
CFAMM00291219 CHEMBL543900 Bioactive SureCN10516212
CFAMM00291217 DNC011854 Investigative Drug RWJ-25730

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27515 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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