CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3435
Family Name Delta-type opioid receptor and Mu-type opioid receptor Ligand H-tyr-c[d-orn-(d Or L)atc-glu]-nh2 Family
No. of Seeds 49 No. of Other Members 19
Family Centroid CFAMM00291330 Functional Category Investigative Drug with Natural Product
Superfamily Mu-type opioid receptor Ligand Alvimopan Superfamily
Class Class 323

Cousin Family NamesSeedsMembers
Vasopressin V2 receptor ligand peptide analog Desmopressin family 111 1472
Alpha-1 adrenergic receptor ligand arylethanolamine derivative... 4 37
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
Trypsin inhibitor polypeptide Aprotinin Family 7 68
Dopamine receptor ligand L-Tyrosine derivative Levodopa Family 4 59
Opioid receptor ligand opiate Levorphanol Family 18 537
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
Oxytocin receptor Ligand Oxytocin Family 30 182
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Penicillin binding protein Inhibitor Cefadroxil Family 5 17
Tyrosine 3-monooxygenase Inhibitor L-tyrosine Family 4 36
Glucan synthesis regulatory protein Inhibitor Caspofungin Family 17 71
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Glycoprotein IIb/IIIa receptor Ligand Tirofiban Family 4 173
Growth hormone-releasing hormone receptor ligand polypeptide ... 14 34
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Mu-type opioid receptor Ligand Alvimopan Family 32 325
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Zucapsacin family 7 177
Eptazocine Hbr family 6 8
Thymopentin family 20 133
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Substance-P receptor Ligand DA-5018 Family 14 73
Plitidepsin family 15 5
Flovagatran family 12 546
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Tryptase Inhibitor APC-366 Family 2 12
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Neuropeptide Y receptor type 1 Ligand Bibp 3226 Family 43 80
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Neprilysin Inhibitor Thiorphan Family 41 68
Plasmepsin-2 Inhibitor KNI-727 Family 3 37
Vasopeptidase Inhibitor Sampatrilat Family 25 9
Neuromedin-K receptor Ligand Senktide Family 15 22
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 20 35
Caspase-1 Inhibitor Yvad Family 1 0
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Kynureninase Inhibitor 3-hydroxyhippuric Acid Family 1 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU84687 F... 2 14
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Cruzipain Inhibitor WRR-204 Family 18 35
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Proto-oncogene tyrosine-protein kinase Src Inhibitor Glu-pro-g... 8 4
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 2 2
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Integrin beta-3 Inhibitor RWJ-53419 Family 6 65
Proto-oncogene tyrosine-protein kinase Src Inhibitor Y-c[d-pen... 20 66
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Integrin beta-3 Inhibitor Lamifiban Family 3 4
Scytalone dehydratase Inhibitor 5-fluoro-2-hydroxy-n-isopropyl... 3 14
Neuromedin-K receptor Ligand PD-160946 Family 10 32
Cathepsin B and Cathepsin L1 Inhibitor MDL-2170 Family 17 24
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 4-hy... 2 13
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-n-diethyl Estrad... 6 16
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
Calcitonin gene-related peptide type 1 receptor Ligand Fvptdvg... 8 8
Caspase-1 Inhibitor Z-vad-cho Family 8 34
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-ethyl Estrone-16... 3 5
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-isopropyl Estrad... 3 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 9 43
Proto-oncogene tyrosine-protein kinase Src Inhibitor Ac-cys-il... 36 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 23 9
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 36 15
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 31 5
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Mu-type opioid receptor and Nociceptin receptor Ligand Ac-ryyr... 60 11
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
C-X-C chemokine receptor type 4 Ligand Cyclo(-d-tyr-l-ala-l-ar... 25 23
Lethal factor Inhibitor N-(3,4,5-trihydroxyphenethyl)oleamide ... 1 3
Prothrombin Inhibitor Cyclotheonamide E5 Family 3 0
Integrin alpha-V Inhibitor C[rgdf-(3s)-carboxymorpholine] Family 10 2
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Mu-type opioid receptor Ligand H-tyr-d-ala-aic-asp-val-val-gly... 48 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 12 8
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 1 2
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Genome polyprotein Inhibitor Acasp-glu-cha-val-prb-cys Family 13 18
Genome polyprotein Inhibitor Acasp-glu-dif-ile-cha-cys-iqc-nle... 9 0
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 152 36
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 3 0
Sodium-dependent dopamine transporter Inhibitor Bip-tyr-thr-pr... 8 2
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 4
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 4
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 48 10
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Gamma-secretase subunit APH-1B and Presenilin-1 Inhibitor 3114... 8 9
Vasopressin V1a receptor Ligand Vasopressin Analogue Family 4 3
Pol polyprotein inhibitor 180968-31-4 family 8 13
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 6 19
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 9
Interstitial collagenase and Low affinity immunoglobulin epsil... 1 1
Integrin beta-1 and Integrin alpha-4 inhibitor (3S,6R,11R,14S)... 1 0
Neprilysin and Aminopeptidase N inhibitor (2S)-2-[[(2S)-2-[[[a... 13 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 0
Neprilysin and Angiotensin-converting enzyme inhibitor AGN-PC-... 3 7
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 6 1
Cathepsin B and Calpain-2 catalytic subunit inhibitor AGN-PC-0... 2 2
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6368456 f... 3 23
Peptide deformylase inhibitor (2R)-2-(cyclopentylmethyl)-3-[fo... 2 0
Tyrosine--tRNA ligase, cytoplasmic inhibitor (2S)-2-[[(2S)-2-a... 5 2
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-ethy... 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(4S)-3... 3 24
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Muscarinic acetylcholine receptor M3 and Beta-2 adrenergic rec... 5 0
Pol polyprotein inhibitor AC1LADQG family 7 1
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 1 0
Pol polyprotein inhibitor MDL 74538 family 11 1
Plasminogen inhibitor (2S)-2-acetamido-5-(diaminomethylideneam... 1 0
Histone deacetylase 1 and Histone deacetylase 6 inhibitor (2E)... 1 0
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 2 1
Angiotensin-converting enzyme and Neprilysin inhibitor (2S,5R)... 15 3
KiSS-1 receptor ligand (2S)-N-[(2S)-1-[[(2S)-4-amino-1-[[(2S)-... 1 0
Metallo-beta-lactamase L1 inhibitor 3-[[1-[[(2R)-1-amino-1-oxo... 1 0
Mu-type opioid receptor ligand 4-[(2S)-3-[[(2S)-1-(4-hydroxyph... 2 6
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 6 2
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Neurotensin receptor type 1 ligand (2S)-2-[[(2S,3S)-2-[[(2S)-2... 2 1
Vasopressin V1a receptor and Vasopressin V1b receptor ligand C... 6 0
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4R)-4-(3-hydroxyp... 4 1
Angiotensin-converting enzyme 2 and Neprilysin inhibitor (2S)-... 6 1
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 1
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 2 6
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 3
Pol polyprotein inhibitor AC1LA3AI family 5 9
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2-me... 4 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 3
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 3 1
Pol polyprotein inhibitor N-[2-Hydroxy-2-(8-Isopropyl-6,9-Diox... 7 6
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN6429531 f... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
72 kDa type IV collagenase and Collagenase 3 inhibitor SureCN7... 5 2
Neprilysin inhibitor benzyl (2S)-3-(4-hydroxyphenyl)-2-[[2-(su... 1 1
Prostaglandin E2 receptor EP4 subtype and Prostaglandin E2 rec... 2 1
Pol polyprotein inhibitor 168912-67-2 family 1 0
Follicle-stimulating hormone receptor ligand SureCN6140614 family 2 8
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Pol polyprotein inhibitor (3S)-N-tert-butyl-2-[(2R)-2-[(3S,6S,... 3 1
Neutrophil collagenase and Collagenase 3 inhibitor [4-(4-chlor... 2 0
Stromelysin-1 and Interstitial collagenase inhibitor (2R)-2-[4... 4 1
Prothrombin inhibitor (2S)-1-[(2R)-2-amino-2-cyclohexylacetyl]... 2 1
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 0
Pol polyprotein inhibitor (2R)-5-[(3S,5R)-3,5-dibenzyl-2-oxopy... 3 0
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 1 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 3 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Gonadotropin-releasing hormone receptor ligand (3R,6S,12S,15S,... 1 0
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(3-hydr... 1 0
Neuropeptide Y receptor type 1 ligand (2R)-5-[[amino-[[2-[2-[2... 1 0
N-acetylated-alpha-linked acidic dipeptidase 2 inhibitor (2S)-... 1 5
Renin inhibitor (2S,4S,5S,7S)-5-amino-4-hydroxy-7-[[4-methoxy-... 2 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 2
Kappa-type opioid receptor ligand N-[(1S)-2-[(3S)-3-hydroxypyr... 2 0
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 5 2
72 kDa type IV collagenase and Interstitial collagenase inhibi... 2 0
Sodium-dependent dopamine transporter inhibitor AC1MIIGH family 2 0
Beta-lactamase inhibitor sodium;(1R,5S)-4-[2-amino-2-(4-hydrox... 1 0
Signal transducer and activator of transcription 3 inhibitor [... 7 25
Dipeptidyl peptidase 4 inhibitor ethyl 2-[[4-[[4-[(2-ethoxy-2-... 7 0
Glutamate receptor ionotropic, NMDA 2B ligand AGN-PC-076B5T fa... 1 0
Genome polyprotein inhibitor (2S)-6-amino-N-[(2S)-6-amino-1-[[... 2 0
Signal transducer and activator of transcription 3 inhibitor [... 3 1
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 5
Sigma non-opioid intracellular receptor 1 ligand N-(1-benzylpi... 1 0
Aminopeptidase N and Cytosol aminopeptidase inhibitor AGN-PC-0... 1 0
C-C chemokine receptor type 3 ligand SureCN3932025 family 1 1
Pol polyprotein inhibitor AC1MHYEO family 1 0
N-formyl-2-(4-hydroxyphenyl)acetamide NP Agn-pc-04a0ox Family 1 1
7-[(1R,2R)-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]-N-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00291329 CHEMBL171763 Bioactive SureCN2268939
CFAMM00291362 CHEMBL2371285 Bioactive SureCN8975338
CFAMM00291334 CHEMBL161336 Bioactive 2-amino-N-[2-[(3-tert-butyl-4-hydroxyphenyl)methyl]-3,7,14-trioxo-1,4,8-triazacyclotetradec-13-yl]-3-phenylpropanamide
CFAMM00291347 CHEMBL326235 Bioactive (2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanamide
CFAMM00291361 CHEMBL2370485 Bioactive (2S)-2-amino-N-[(3S,6S,9R)-6-benzyl-3-methyl-2,5,8-trioxo-1,4,7-triazacyclotridec-9-yl]-3-(4-hydroxyphenyl)propanamide
CFAMM00291327 CHEMBL2371291 Bioactive SureCN8975567
CFAMM00291340 CHEMBL323024 Bioactive (2S,5S,13R)-13-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-[(2-methylphenyl)methyl]-3,8,14-trioxo-1,4,9-triazacyclotetradecane-5-carboxamide
CFAMM00291333 CHEMBL2372195 Bioactive (2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3,3-dimethylbutanamide
CFAMM00291360 CHEMBL3037875 Bioactive (2S,5S,13R)-13-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-3,8,14-trioxospiro[1,4,9-triazacyclotetradecane-2,3'-2,4-dihydro-1H-naphthalene]-5-carboxamide
CFAMM00291339 CHEMBL2372817 Bioactive (2S,5S,14S)-14-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-benzyl-3,8,15-trioxo-1,4,9-triazacyclopentadecane-5-carboxamide
CFAMM00291353 CHEMBL496391 Bioactive (2S)-N-[(2S)-1-amino-3-(3-tert-butyl-4-hydroxyphenyl)-1-oxopropan-2-yl]-2-[[(2S)-2-amino-3-phenylpropanoyl]-methylamino]-3-methylbutanamide
CFAMM00291345 CHEMBL213186 Bioactive N-[(2S)-1-[4-(7-aminoheptylamino)butylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]butanamide
CFAMM00291352 CHEMBL2371264 Bioactive (2S)-2-amino-N-[(6S,9S)-6-[(3-tert-butyl-4-hydroxyphenyl)methyl]-2,5,8-trioxo-1,4,7-triazacyclotridec-9-yl]-3-phenylpropanamide
CFAMM00291337 CHEMBL153017 Bioactive AGN-PC-075TEF
CFAMM00291357 CHEMBL107580 Bioactive (2S,5S,13R)-13-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-benzyl-3,8,14-trioxo-1,4,9-triazacyclotetradecane-5-carboxamide
CFAMM00291336 CHEMBL2372833 Bioactive (2S,5S,12S)-12-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-benzyl-3,10,13-trioxo-1,4,9-triazacyclotridecane-5-carboxamide
CFAMM00291338 DNC011885 Investigative Drug H-Tyr-c[D-Orn-Aic-Glu]-NH2
CFAMM00291330 DNC011868 Investigative Drug H-Tyr-c[D-Orn-(D or L)Atc-Glu]-NH2

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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