CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3436
Family Name Sodium-dependent serotonin transporter Inhibitor Irindalone Family
No. of Seeds 16 No. of Other Members 9
Family Centroid CFAMM00291373 Functional Category Investigative Drug
Superfamily Substance-P receptor Ligand Vestipitant Superfamily
Class Class 1148

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Substance-P receptor Ligand Orvepitant Family 11 46
Substance-P receptor Ligand Vestipitant Family 14 137
Zicronapine family 43 62
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Reverse transcriptase Inhibitor 3-benzylamino-5-ethyl-6-methyl... 2 24
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 3 12
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 11 6
Histamine H3 receptor Ligand N-benzyl-4-cyclopentylpiperazine-... 3 19
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Dipeptidyl peptidase 4 Inhibitor 1-benzyl-4-(2,4-dichloropheny... 2 10
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Induced myeloid leukemia cell differentiation protein Mcl-1 an... 2 7
Sodium-dependent serotonin transporter Inhibitor Tefludazine F... 8 9
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 4 24
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 4 13
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 7 9
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 5 20
5-hydroxytryptamine receptor 7 and Sodium-dependent serotonin ... 5 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 7 1
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 16 11
Survival motor neuron protein inhibitor CHEMBL1323700 family 1 4
D(1A) dopamine receptor and D(2) dopamine receptor ligand Sure... 2 0
D(1A) dopamine receptor and 5-hydroxytryptamine receptor 2A li... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 6 0
Dipeptidyl peptidase 8 inhibitor (2S)-2-amino-4-[4-[bis(4-fluo... 2 9
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 2 5
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 9 1
Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthy... 2 0
P2X purinoceptor 7 inhibitor (4S)-3-methyl-N-[[2-methyl-3-(tri... 3 0
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 1
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 3 0
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 1 0
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
C-C chemokine receptor type 5 ligand AC1L9YPM family 3 6
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 1
Sodium-dependent noradrenaline transporter and Muscarinic acet... 1 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Prostaglandin E synthase inhibitor AGN-PC-09QMEJ family 2 0
C-C chemokine receptor type 3 ligand 4-(benzenesulfonyl)-N-[(1... 1 1
Histamine H3 receptor ligand (2S)-N-(2,3-dihydro-1H-inden-2-yl... 2 1
Melanin-concentrating hormone receptor 1 ligand 1-[[4-(4-fluor... 2 10
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 7


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00291365 CHEMBL590833 Bioactive [2-[3,5-bis(trifluoromethyl)phenyl]pyrrolidin-1-yl]-[(2S)-2-(4-fluoro-2-methylphenyl)piperazin-1-yl]methanone
CFAMM00291373 DNC011870 Investigative Drug Irindalone

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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