CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3438
Family Name D(2) dopamine receptor Ligand Epidepride Family
No. of Seeds 31 No. of Other Members 66
Family Centroid CFAMM00291459 Functional Category Investigative Drug with Natural Product
Superfamily D(2) dopamine receptor Ligand Epidepride Superfamily
Class Class 322

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Nemonapride Family 70 283
D(2) dopamine receptor Ligand Sulpiride Family 7 38
D(2) dopamine receptor Ligand Remoxipride Family 12 84
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
Acetylcholinesterase Inhibitor Donepezil Family 23 242
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Insulin receptor Ligand Meglitinides Family 9 25
Histamine H1 receptor Ligand Tranilast Family 5 125
Zucapsacin family 7 177
C-C chemokine receptor type 2 Ligand CCX915 Family 3 25
Leukotriene B4 receptor 1 Ligand Ltb 019 Family 3 35
Endothelin-1 receptor Ligand Atrasentan Family 127 336
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Myeloperoxidase Inhibitor AZD5904 Family 1 2
Substance-P receptor Ligand Ezlopitant Family 10 207
5-hydroxytryptamine receptor 3A Ligand KB-6806 Family 12 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 23
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Histamine H3 receptor Ligand A-317920 Family 9 240
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Poly [ADP-ribose] polymerase 1 Inhibitor 3-methoxybenzamide Fa... 2 23
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 16
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Potassium ... 1 15
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Scytalone dehydratase Inhibitor 5-fluoro-2-hydroxy-n-isopropyl... 3 14
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 14
Histamine H3 receptor Ligand A-349821 Family 49 228
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Interstitial collagenase Inhibitor N-hydroxycarbamoylmethyl-4-... 5 24
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Amyloid beta A4 protein Inhibitor 6-iodo-4'-methylaminoflavone... 3 33
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Multidrug resistance protein 1 and Multidrug resistance-associ... 3 55
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Histone deacetylase 1 Inhibitor N-hydroxy-8-(2-methoxyphenyl)-... 2 14
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Proto-oncogene tyrosine-protein kinase receptor Ret Ligand (z)... 1 60
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 14
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
5-hydroxytryptamine receptor 4 Ligand SB-207710 Family 10 5
Reverse transcriptase Inhibitor 10-propyl-10h-dibenzo[b,f][1,4... 9 60
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 5 17
Acetylcholinesterase Inhibitor 6-methyl-4-(4-benzoylpiperazin-... 2 6
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
Tubulin beta chain Inhibitor Gnf-pf-117 Family 2 16
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand N-... 1 2
Disintegrin and metalloproteinase domain-containing protein 17... 28 10
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Stromelysin-1 and 72 kDa type IV collagenase inhibitor [(2S)-2... 2 2
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide, 8... 4 15
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 13
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
D(2) dopamine receptor and D(3) dopamine receptor ligand 5-bro... 3 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 49 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Renin inhibitor N-[(2S,4S,5S,7S)-7-[2-(1-acetylpiperidin-4-yl)... 2 1
D(2) dopamine receptor ligand (E)-2,3-dihydroxybut-2-enedioic ... 6 10
D(2) dopamine receptor ligand 2-bromo-3-chloro-N-[[(2S)-1-ethy... 1 1
D(2) dopamine receptor ligand 2-chloro-3-ethyl-N-[[(2S)-1-ethy... 3 0
D(2) dopamine receptor ligand 2-bromo-N-[[(2S)-1-ethylpyrrolid... 3 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 10
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
Multidrug resistance protein 1 inhibitor 1-[2-[(2R)-3-[4-(2,3-... 2 41
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Mu-type opioid receptor ligand 3-[(3R,4R)-1-[(2,4-dimethoxyphe... 2 4
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 4 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 2
Carbonic anhydrase 9 and Carbonic anhydrase 14 inhibitor N-[2-... 6 10
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 7 9
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 11 9
D(3) dopamine receptor and D(4) dopamine receptor ligand N-[4-... 6 16
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
Pol polyprotein inhibitor CHEMBL305466 family 4 7
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 6
D(2) dopamine receptor ligand AGN-PC-0041GL family 2 0
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Mu-type opioid receptor ligand AGN-PC-075GAC family 16 8
Mu-type opioid receptor ligand AGN-PC-075GAW family 2 1
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 3
Collagenase 3 and 72 kDa type IV collagenase inhibitor N-[(3,4... 1 6
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Potassium voltage-gated channel subfamily H member 2 and Melan... 4 22
Melanocortin receptor 4 ligand 2-[2-(5-bromo-2-methoxyphenyl)e... 6 12
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
5-hydroxytryptamine receptor 1A ligand (3S)-3-[4-(7,9-dioxo-8-... 2 0
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-[cyano-(2-meth... 1 0
Integrin beta-3 and Integrin alpha-2 inhibitor 3-(4-methoxyphe... 4 6
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 6
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 5
Histamine H3 receptor and Sodium-dependent serotonin transport... 14 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 2 6
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 2
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 7
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 11 4
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Sigma non-opioid intracellular receptor 1 and D(3) dopamine re... 26 8
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 5
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 2
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
C-C chemokine receptor type 5 ligand (4-chlorophenyl) N-[1-[(4... 2 2
Leukotriene A-4 hydrolase inhibitor SureCN5313952 family 4 1
Growth hormone secretagogue receptor type 1 ligand N-[4-[(2S)-... 1 0
Dipeptidyl peptidase 4 inhibitor SureCN5777647 family 1 0
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 3 4
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 3 1
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 5 2
C-C chemokine receptor type 3 ligand N-[(3R)-1-[(6-fluoronapht... 1 4
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Cathepsin K inhibitor (2S)-2-[[2-(3,4-dimethoxyphenyl)acetyl]a... 1 1
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
Capsid scaffolding protein inhibitor AC1LAC52 family 1 0
Histamine H1 receptor ligand SureCN7952197 family 1 0
Histone deacetylase 3 and Histone deacetylase 6 inhibitor (E)-... 1 1
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 2-ben... 1 0
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 1 0
15-hydroxyprostaglandin dehydrogenase [NAD(+)] and Retinal deh... 1 1
Nonstructural protein 1 and Thioredoxin glutathione reductase ... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 3
Histone deacetylase 1 and Histone deacetylase 2 inhibitor 4-[3... 4 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Prostaglandin D2 receptor ligand (E)-7-[(1S,3S,4R,5R)-4-(1,3-b... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 1 0
Putative NP ZINC02127056 Family 4 1
NP ((1r,4as,8as)-4a-hydroxy-1-(3,4,5-trimethoxyphenyl)octahydr... 3 3
Putative NP ZINC00519603 Family 8 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00291386 CHEMBL42953 Bioactive N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-5-(3-fluoropropyl)-2,3-dimethoxybenzamide
CFAMM00291463 CHEMBL54866 Bioactive AGN-PC-073SK4
CFAMM00291392 CHEMBL340471 Bioactive 152128-14-8
CFAMM00291470 CHEMBL392158 Bioactive Fallypride
CFAMM00291435 CHEMBL123282 Bioactive Benzamide, 2,3-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-
CFAMM00291474 CHEMBL1276647 Bioactive 2,3-diethyl-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-5-hydroxy-6-methoxybenzamide
CFAMM00291404 CHEMBL75876 Bioactive AC1MIALF
CFAMM00291434 CHEMBL1276325 Bioactive N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-3-hydroxy-5-iodo-2,6-dimethoxybenzamide
CFAMM00291413 CHEMBL288704 Bioactive N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-5-(2-fluoroethyl)-2,3-dimethoxybenzamide
CFAMM00291384 CHEMBL1276559 Bioactive 3-ethyl-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-fluoro-5-hydroxy-6-methoxybenzamide
CFAMM00291399 CHEMBL1276459 Bioactive 5-bromo-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-3-hydroxy-2-methoxybenzamide
CFAMM00291419 CHEMBL289330 Bioactive 107188-74-9
CFAMM00291461 CHEMBL2112605 Bioactive AC1MIF8R
CFAMM00291432 CHEMBL1276763 Bioactive N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-3-hydroxy-2-methoxy-6-methyl-5-propylbenzamide
CFAMM00291412 CHEMBL176458 Bioactive SureCN10762595
CFAMM00291445 CHEMBL241169 Bioactive 5-iodo-2,3-dimethoxy-N-[[(2S)-1-prop-2-enylpyrrolidin-2-yl]methyl]benzamide
CFAMM00291460 CHEMBL2112607 Bioactive 87964-79-2
CFAMM00291439 CHEMBL240106 Bioactive SureCN10355478
CFAMM00291451 CHEMBL308524 Bioactive ioxipride
CFAMM00291421 CHEMBL48450 Bioactive Iodine-123-ibf
CFAMM00291427 CHEMBL1276400 Bioactive N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-3-hydroxy-2,6-dimethoxybenzamide
CFAMM00291417 CHEMBL1276496 Bioactive N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-3-hydroxy-5-iodo-2-methoxybenzamide
CFAMM00291465 CHEMBL73683 Bioactive SureCN10355675
CFAMM00291420 CHEMBL177762 Bioactive SureCN10355480
CFAMM00291407 CHEMBL1276528 Bioactive N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-3-hydroxy-2-methoxy-5,6-dimethylbenzamide
CFAMM00291477 CHEMBL1276585 Bioactive N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-3-hydroxy-2-methoxy-5-propylbenzamide
CFAMM00291387 CHEMBL76266 Bioactive SureCN10355445
CFAMM00291406 CHEMBL1276529 Bioactive 5-ethyl-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-3-hydroxy-2-methoxybenzamide
CFAMM00291394 CHEMBL305916 Bioactive SureCN9549979
CFAMM00291456 CHEMBL43552 Bioactive N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2,3-dimethoxy-5-propylbenzamide
CFAMM00291459 DNC011882 Investigative Drug EPIDEPRIDE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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