CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3442
Family Name 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 1D Ligand Phenylpiperazine Family
No. of Seeds 6 No. of Other Members 45
Family Centroid CFAMM00291567 Functional Category Investigative Drug
Superfamily 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 1D Binder Superfamily
Class Class 2765

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
Dopamine receptor Ligand Domperidone Family 2 21
Peptide deformylase, mitochondrial Inhibitor Proguanil Family 8 46
Serotonin re-uptake inhibitor Dibenzazepine Clomipramine Family 2 23
Histamine H1 receptor Ligand Antazoline Family 5 57
D(2) dopamine receptor Ligand Nomifensine Family 6 100
Motilin receptor Ligand GSK962040 Family 30 457
5-hydroxytryptamine receptor 1A and Sigma non-opioid intracell... 7 28
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 5 65
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 1,3,... 3 4
Progesterone receptor Ligand 2,2,4-trimethyl-6-phenyl-1,2-dihy... 5 82
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
Histone Deacetylase 8 Inhibitor 6-(2-mercaptoacetamido)-n-phen... 4 8
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-chloro-phenyl)... 5 50
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Sodiu... 2 11
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 34
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 42
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 3 31
Acetylcholinesterase Inhibitor (3-hydroxy-2-methyl-phenyl)-tri... 4 25
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 4 18
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 2
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 7 27
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 6 12
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 4 3
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 2
D(3) dopamine receptor and D(2) dopamine receptor ligand RGH-1... 8 0
5-hydroxytryptamine receptor 7 ligand 1-[2-(4-nitrophenyl)phen... 1 0
Substance-P receptor ligand (2R,3R)-2-benzhydryl-N-(2-iodophen... 2 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 3
5-hydroxytryptamine receptor 2C ligand SureCN5872545 family 3 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 1 0
5-hydroxytryptamine receptor 4 ligand AC1L4N66 family 2 4
5-hydroxytryptamine receptor 2B and Prostaglandin G/H synthase... 1 16
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 1 1
Proteasome subunit beta type-5 and Proteasome subunit beta typ... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 4
5-hydroxytryptamine receptor 2C ligand SureCN5872565 family 1 0
Polyamine oxidase inhibitor AGN-PC-07C3XH family 1 2
Monoglyceride lipase and Fatty-acid amide hydrolase 1 inhibito... 1 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00291601 CHEMBL1256029 Bioactive 1-(3-Chlorophenyl)piperazine dihydrochloride
CFAMM00291557 DNC012591 Investigative Drug 1-(2-Chloro-phenyl)-piperazine
CFAMM00291571 DNC011937 Investigative Drug 1-(3-Fluoro-phenyl)-piperazine
CFAMM00291577 DNC011901 Investigative Drug 1-(2-Fluoro-phenyl)-piperazine
CFAMM00291567 DNC011899 Investigative Drug PHENYLPIPERAZINE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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