CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3443
Family Name Prostaglandin G/H synthase 2 Inhibitor L-761000 Family
No. of Seeds 8 No. of Other Members 44
Family Centroid CFAMM00291620 Functional Category Investigative Drug with Natural Product
Superfamily Prostaglandin G/H synthase 2 Inhibitor L-761000 Superfamily
Class Class 2770

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Cyclooxygenase Inhibitor Indomethacin Family 6 271
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Phospholipase A2, membrane associated Inhibitor Varespladib Fa... 37 190
Arachidonate 5-lipoxygenase Inhibitor MK-591 Family 9 161
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
Indeglitazar family 3 39
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Platelet-derived growth factor receptor alpha and Platelet-der... 2 9
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Oestrogen receptor and Estrogen receptor beta Ligand ZK-119010... 2 16
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Fatty acid-binding protein, adipocyte Inhibitor 1-benzyl-2,3-d... 1 8
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Cyclin-dependent kinase 2 and G1/S-specific cyclin-E1 Inhibito... 5 1
DNA topoisomerase 2-beta Inhibitor 3-(6-(furan-2-yl)-4-phenylp... 1 3
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Androgen receptor Ligand 11-methyl-6,11-dihydro-5h-benzo[a]car... 7 9
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... 1 0
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 1 18
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 391
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Neuropeptide Y receptor type 1 ligand SureCN7959923 family 1 6
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 8 21
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Renin inhibitor SureCN1144364 family 3 15
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 1 6
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
5-hydroxytryptamine receptor 6 ligand SureCN5502542 family 4 2
Cellular tumor antigen p53 inhibitor CHEMBL1395699 family 1 30
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
Prostaglandin D2 receptor 2 and Prostaglandin D2 receptor liga... 20 37
5-hydroxytryptamine receptor 6 ligand 1-[9-(benzenesulfonyl)-6... 11 2
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-0759OR family 4 7
Prostaglandin D2 receptor 2 ligand SureCN2189431 family 7 1
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 5 12
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Prostaglandin D2 receptor and Prostaglandin E2 receptor EP2 su... 2 0
NS5B protein inhibitor AC1O5AET family 3 1
Glucagon receptor ligand 3-[[4-[(2S)-2-[5-(trifluoromethoxy)-1... 1 2
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Integrase inhibitor (Z)-4-[1-[(4-fluorophenyl)methyl]-5-methox... 1 0
Vascular endothelial growth factor receptor 2 and Vascular end... 2 52
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Peroxisome proliferator-activated receptor alpha and Peroxisom... 1 4
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Cytosolic phospholipase A2 inhibitor AGN-PC-00BH8R family 6 13
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Peroxisome proliferator-activated receptor delta and Peroxisom... 1 1
3-oxo-5-alpha-steroid 4-dehydrogenase 2 inhibitor 4-(benzyloxy... 1 10
Translocator protein inhibitor AGN-PC-07BUUF family 11 2
Translocator protein inhibitor N,N-diethyl-11-(2-fluoroethyl)-... 2 1
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Peroxisome proliferator-activated receptor delta and Peroxisom... 2 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 4 1
Neutrophil collagenase and Stromelysin-1 inhibitor (3R)-N-hydr... 2 0
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
5-hydroxytryptamine receptor 6 ligand 1-[9-(2,5-dimethoxypheny... 2 0
Prostaglandin E synthase 2 inhibitor AGN-PC-075D2E family 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 1 6
Cysteinyl leukotriene receptor 1 ligand 3-[5-[[3-[(E)-2-(7-chl... 1 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 18000... 1 1
Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluor... 3 0
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 6 5
Glycogen synthase kinase-3 beta and G2/mitotic-specific cyclin... 4 13
Phospholipase A2, membrane associated inhibitor 2-(1-benzyl-2-... 2 1
Glutamate receptor 2 and Glutamate receptor 4 ligand SureCN828... 1 0
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 1 0
Aldose reductase inhibitor [1-(3,5-difluoro-4-hydroxyphenyl)py... 3 2
Indoles Metabolite Mukeic acid Family 1 1
NP (6-bromo-3,4-dihydro-1h-pyrido[4,3-b]indol-2(5h)-yl)(4-meth... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00291631 CHEMBL159740 Bioactive SureCN3239976
CFAMM00291610 CHEMBL320140 Bioactive SureCN8607505
CFAMM00291630 CHEMBL162743 Bioactive AGN-PC-004PUF
CFAMM00291635 CHEMBL349248 Bioactive SureCN8878139
CFAMM00291612 CHEMBL162202 Bioactive SureCN3246589
CFAMM00291611 CHEMBL349600 Bioactive AGN-PC-025SCC
CFAMM00291620 DNC011922 Investigative Drug L-761000

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26843 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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