CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3445
Family Name Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464 Family
No. of Seeds 3 No. of Other Members 10
Family Centroid CFAMM00291684 Functional Category Investigative Drug
Superfamily Corticotropin-releasing factor receptor 1 and Proto-oncogene tyrosine-protein kinase Src Binder Superfamily
Class Class 903

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Cytochrome P450 3A4 Inhibitor Clotrimazole Family 16 145
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Benzodiazepine receptor Ligand Midazolam Family 5 160
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Type-1 angiotensin II receptor Ligand Forasartan Family 3 253
Histamine H1 receptor Ligand Mizolastine Family 14 603
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Transient receptor potential cation channel subfamily V member... 6 66
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Hepatocyte growth factor receptor Ligand SGX523 Family 1 15
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Reverse transcriptase Inhibitor Dapivirine Family 5 72
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Adenosine receptor A1 Ligand SLV320 Family 6 79
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Gamma-aminobutyric acid A receptor Ligand Ocinaplon Family 1 10
HCV NS4B protein Inhibitor Clemizole Family 2 43
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
GDC-0349 family 44 77
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
PF-4217903 family 14 65
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Tryptase Inhibitor Babim Family 12 90
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Glucan synthesis regulatory protein Inhibitor Pyridobenzimidaz... 2 12
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Histamine H3 receptor Ligand SCH79687 Family 11 29
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... 4 12
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Aromatase and Thromboxane-A synthase Inhibitor 6-(1h-imidazol-... 3 8
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Metabotropic glutamate receptor 5 Ligand 3-(1-pyridin-2-yl-1h-... 3 6
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Mitogen-activated protein kinase kinase kinase 8 and Stromelys... 6 53
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
Aromatase Inhibitor NSC-356781 Family 3 10
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... 2 3
Metabotropic glutamate receptor 5 Ligand 2-(3-bromophenyl)-7-m... 3 1
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 2
Metabotropic glutamate receptor 5 Ligand 5-(2-(3-chlorophenyl)... 2 13
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Adenosine kinase inhibitor GP683 family 12 7
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Adenosine kinase inhibitor abt-702 family 14 1
Prothrombin inhibitor SureCN5856722 family 3 16
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 3
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
Platelet-activating factor receptor ligand SureCN9383514 family 4 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 3 5
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 4
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Tyrosine-protein kinase ABL1 and Mitogen-activated protein kin... 1 3
Transient receptor potential cation channel subfamily V member... 1 0
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... 8 7
Histamine H3 receptor ligand SureCN4018269 family 1 0
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 1 inhibi... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... 2 0
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 27
Survival motor neuron protein and Menin inhibitor CHEMBL132797... 1 1
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Dihydrofolate reductase inhibitor AC1LAKQL family 3 1
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Dihydrofolate reductase inhibitor AC1LAKWV family 2 0
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1
Nuclear receptor ROR-gamma and Mitogen-activated protein kinas... 1 10
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Tyrosine-protein kinase JAK3 inhibitor N-methyl-N-[(1S,5S)-2-m... 2 12
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Corticotropin-releasing factor receptor 1 ligand 9-(2-bromo-4-... 15 3
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Toll-like receptor 7 ligand 6-amino-2-(butylamino)-9-[[4-(dime... 5 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 9 6
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(1H-pyr... 2 8
Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 8-... 6 2
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Ribosomal protein S6 kinase alpha-5 inhibitor AGN-PC-075HAD fa... 2 0
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 0
Dipeptidyl peptidase 4 inhibitor Aminomethylpyrimidine 1ck family 6 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Vascular endothelial growth factor receptor 2 and Fibroblast g... 5 2
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
Cell division cycle 7-related protein kinase and Protein DBF4 ... 15 7
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 0
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Transient receptor potential cation channel subfamily V member... 4 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 0
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-... 2 5
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
D(4) dopamine receptor and Alpha-1D adrenergic receptor ligand... 3 3
Activated CDC42 kinase 1 inhibitor N,N-dimethyl-4-[4-[[(2S)-ox... 4 2
Transient receptor potential cation channel subfamily V member... 4 0
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 0
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Beta-secretase 1 and Potassium voltage-gated channel subfamily... 3 4
Metabotropic glutamate receptor 2 ligand 3-(cyclopropylmethyl)... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Urokinase plasminogen activator surface receptor ligand 3-(1H-... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 5
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
Tyrosine-protein kinase JAK1 and Aurora kinase A inhibitor CHE... 2 0
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Fatty-acid amide hydrolase 1 inhibitor 4-(3-phenyl-1,2,4-thiad... 2 1
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 2 0
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Cytochrome P450 3A4 and Cytochrome P450 2C8 inhibitor N-[3-[(1... 1 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Cathepsin K inhibitor SureCN4141224 family 3 0
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 5
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 3 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1-met... 2 0
Cathepsin K inhibitor 4-[2,2-dimethylpropyl-[[4-(1,2,4-triazol... 2 1
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Cathepsin K and Cathepsin L1 inhibitor 5-[3-(3,4-dihydro-1H-is... 2 0
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 1 0
Epidermal growth factor receptor ligand Pyrroloquinazoline der... 7 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 14 14
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-03IU3J family 2 0
Corticotropin-releasing factor receptor 1 ligand 4-[7-(dipropy... 1 1
Type-1 angiotensin II receptor ligand SureCN7390271 family 2 1
Adenosine kinase inhibitor SureCN8248615 family 2 3
Coagulation factor X inhibitor SureCN1652469 family 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Nociceptin receptor and Mu-type opioid receptor ligand SureCN5... 1 0
Adenosine receptor A1 ligand 3-[(2-chlorophenyl)methyl]-N-cycl... 1 1
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 4 0
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine der... 4 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
G2/mitotic-specific cyclin-B2 and Cyclin-dependent kinase 1 in... 2 1
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Neuropeptide Y receptor type 5 ligand SureCN4464548 family 17 2
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 2 0
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 3 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0
High affinity nerve growth factor receptor ligand SureCN490352... 3 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Activated CDC42 kinase 1 inhibitor AGN-PC-078WDN family 7 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Nociceptin receptor and Mu-type opioid receptor ligand 2-(3-ch... 2 0
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-[2-... 9 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
LIM domain kinase 1 and LIM domain kinase 2 inhibitor (2S)-N'-... 9 0
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 1 0
Adenosine kinase inhibitor AGN-PC-074DKZ family 1 0
Dihydrofolate reductase inhibitor 5-[(7-chloro-10-methylsulfan... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2
Nitric oxide synthase, inducible inhibitor N-(3-chlorophenyl)-... 1 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00291684 DNC011928 Investigative Drug CGP-62464
CFAMM00291692 DNC012288 Investigative Drug 4-Chloro-5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

23106 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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