CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3446
Family Name Delta-type opioid receptor and Kappa-type opioid receptor Ligand RTI-5989-23 Family
No. of Seeds 44 No. of Other Members 3
Family Centroid CFAMM00291700 Functional Category Investigative Drug
Superfamily Delta-type opioid receptor and Kappa-type opioid receptor Ligand RTI-5989-23 Superfamily
Class Class 2771

Cousin Family NamesSeedsMembers
D(2) dopamine receptor ligand catecholamine Dopamine family 9 170
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Beta adrenergic receptor ligand catecholamine group Isoprotere... 7 130
Histamine H1 receptor Ligand Terfenadine Family 3 50
Oestrogen receptor Ligand triphenyl ethylene stilbene derivati... 22 420
Opioid receptor ligand opiate Levorphanol Family 18 537
Alpha adrenergic receptor ligand catecholamine Phenylephrine F... 4 39
Beta-2 adrenergic receptor ligand catecholamine Salbutamol Family 10 90
D(1A) dopamine receptor Ligand Fenoldopam Family 4 78
Sigma non-opioid intracellular receptor 1 ligand opiate Dextro... 9 33
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Muscarinic acetylcholine receptor M1 Ligand Trihexyphenidyl Fa... 14 199
Histamine H1 receptor ligand diphenylpiperidine analog Dipheny... 13 224
Kappa-type opioid receptor Ligand Dezocine Family 36 46
Mu-type opioid receptor ligand opiate Methadyl Acetate Family 5 9
Mu-type opioid receptor Ligand Alvimopan Family 32 325
D(2) dopamine receptor Ligand Quinagolide Family 2 0
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Nicotinic acetylcholine receptor Ligand Benztropine Mesylate F... 10 20
Noradrenergic re-uptake Inhibitor Desvenalfaxine Succinate Family 2 4
Eptazocine Hbr family 6 8
Noradrenergic re-uptake and Opioid receptor Ligand Tapentadol ... 21 79
CORT-108297 family 46 44
5-hydroxytryptamine receptor 1A Ligand (s)-uh-301 Family 35 20
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 6 40
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Fibroblast growth factor receptor Ligand SU5403 Family 8 8
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Sulfen... 5 13
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Amine oxidase [flavin-containing] B Inhibitor 5-hydroxy-n-prop... 3 5
Adenosine receptor A3 and D(2) dopamine receptor Ligand (+)-bu... 5 14
Voltage-dependent N-type calcium channel subunit alpha-1B Liga... 1 0
Acetylcholinesterase and Cholinesterase Inhibitor N,n'-(1',10'... 12 8
Adenosine receptor A3 and Mu-type opioid receptor Ligand GBR-1... 80 110
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-n-diethyl Estrad... 6 16
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 7 22
Oestrogen receptor and Estrogen receptor beta Ligand 6-(4-hydr... 30 63
Estradiol 17-beta-dehydrogenase 1 Inhibitor N-ethyl Estrone-16... 3 5
Cytochrome P450 2D6 Inhibitor Bs 7840 Family 4 9
Sodium-dependent dopamine transporter and Sodium-dependent nor... 9 16
Potassium voltage-gated channel subfamily A member 5 Ligand 2-... 3 1
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 19
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 11 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 18 13
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-237... 21 56
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 9 7
Mu-type opioid receptor Ligand Cyprodime Family 12 8
Sodium-dependent dopamine transporter and Sodium-dependent nor... 10 9
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 3 4
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 1 2
D(1A) dopamine receptor Ligand 5-(2-amino-ethyl)-2-chloro-phen... 1 0
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-ri... 5 12
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Kappa-type opioid receptor Ligand Morphinan Cyclic Imine Analo... 3 1
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TF5... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 12
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-074TFC... 2 7
Glutamate receptor ionotropic, NMDA 3A and Glutamate receptor ... 2 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 0
Sigma non-opioid intracellular receptor 1 and Mu-type opioid r... 7 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 14 12
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Mu-type opioid receptor and Sigma non-opioid intracellular rec... 10 20
Estrogen receptor and Estrogen receptor beta ligand AGN-PC-01Z... 2 4
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 8
Sigma non-opioid intracellular receptor 1 ligand 1-[4-(4-metho... 1 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand (2R,... 3 2
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 0
Sodium-dependent dopamine transporter and Sodium-dependent ser... 6 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 4 2
D(1A) dopamine receptor ligand (5S)-5-(4-azidophenyl)-8-iodo-3... 2 0
Sigma non-opioid intracellular receptor 1 ligand CHEMBL154452 ... 2 1
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
D(2) dopamine receptor and D(1A) dopamine receptor ligand ISOM... 2 5
D(1A) dopamine receptor ligand (5R)-8-bromo-3-methyl-5-phenyl-... 6 15
Histamine H3 receptor ligand cyclohexyl-[4-(3-piperidin-1-ylpr... 4 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 2 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 8 0
Sodium-dependent dopamine transporter and Transporter inhibito... 2 0
Delta-type opioid receptor ligand N-[(7S)-5-(3-hydroxyphenyl)-... 9 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 1
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 8
Kinesin-like protein KIF11 inhibitor 3-[2-aminoethylsulfanyl-(... 2 5
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
D(1A) dopamine receptor and D(2) dopamine receptor ligand (2R,... 1 0
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Kappa-type opioid receptor ligand CHEMBL2367762 family 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 4
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 5
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
D(1A) dopamine receptor and D(2) dopamine receptor ligand Biom... 3 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Sodium-dependent dopamine transporter and Sodium-dependent ser... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(3-hydr... 1 0
Vesicular acetylcholine transporter inhibitor (2R,3R)-5-(3-flu... 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 6
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
D(1A) dopamine receptor and D(1B) dopamine receptor ligand Sur... 6 6
D(1A) dopamine receptor and D(1B) dopamine receptor ligand (6a... 1 0
D(1A) dopamine receptor and D(1B) dopamine receptor ligand met... 1 1
D(1A) dopamine receptor and D(1B) dopamine receptor ligand N-[... 1 0
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 2
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 2 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00291709 CHEMBL68855 Bioactive 3-[(3R)-1-(2-phenylethyl)piperidin-3-yl]phenol
CFAMM00291699 CHEMBL95343 Bioactive 3-[(3S,4S)-3,4-dimethyl-1-(5-methylhexyl)piperidin-4-yl]phenol
CFAMM00291698 CHEMBL98568 Bioactive 3-[(3R,4R)-3,4-dimethyl-1-(5-methylhexyl)piperidin-4-yl]phenol
CFAMM00291707 CHEMBL318954 Bioactive AGN-PC-074TCN
CFAMM00291697 CHEMBL97509 Bioactive 3-[(3R,4R)-1-(2-cyclohexylethyl)-3,4-dimethylpiperidin-4-yl]phenol
CFAMM00291703 CHEMBL95620 Bioactive 3-[(3R,4R)-1-(2-cyclopentylethyl)-3,4-dimethylpiperidin-4-yl]phenol
CFAMM00291706 CHEMBL95647 Bioactive 3-[(3R,4R)-1-(3-cyclopentylpropyl)-3,4-dimethylpiperidin-4-yl]phenol
CFAMM00291696 CHEMBL97223 Bioactive 3-[(3R,4R)-3,4-dimethyl-1-(4-methylpentyl)piperidin-4-yl]phenol
CFAMM00291712 CHEMBL96058 Bioactive 3-[(3R,4R)-1-hexyl-3,4-dimethylpiperidin-4-yl]phenol
CFAMM00291702 CHEMBL150052 Bioactive 3-[(3S,4S)-3,4-dimethyl-1-[(E)-3-phenylprop-2-enyl]piperidin-4-yl]phenol
CFAMM00291705 CHEMBL97731 Bioactive 3-[(3S,4S)-1-hexyl-3,4-dimethylpiperidin-4-yl]phenol
CFAMM00291695 CHEMBL1672190 Bioactive 3-[(3R,4R)-3,4-dimethyl-1-[(2-phenylcyclopropyl)methyl]piperidin-4-yl]phenol
CFAMM00291711 CHEMBL431845 Bioactive 3-[(3R,4R)-3,4-dimethyl-1-[3-(2-methylphenyl)propyl]piperidin-4-yl]phenol
CFAMM00291701 CHEMBL431266 Bioactive SureCN12168480
CFAMM00291700 DNC011933 Investigative Drug RTI-5989-23

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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