CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3449
Family Name 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 1D Ligand 1-(3-nitro-phenyl)-piperazine Family
No. of Seeds 3 No. of Other Members 31
Family Centroid CFAMM00291747 Functional Category Investigative Drug with Human Metabolite
Superfamily 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine receptor 1D Ligand 1-(3-nitro-phenyl)-piperazine Superfamily
Class Class 2177

Cousin Family NamesSeedsMembers
Glutamate receptor AMPA subtype Ligand Becampanel Family 2 20
5-hydroxytryptamine receptor 1A and Sigma non-opioid intracell... 7 28
Beta-lactamase Inhibitor 3-nitrophenylboronic Acid Family 4 15
Carbonic anhydrase 2 Inhibitor 4-nitrophenylsulfamide Family 1 2
Dipeptidyl peptidase 4 Inhibitor (3s,4r)-3-butyl-1-phenylpiper... 2 40
Histamine H3 receptor Ligand (r)-1-(4-nitrophenethyl)-2-methyl... 16 38
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Nitric oxide synthase, brain Inhibitor N*1*-(5-methyl-2-nitro-... 1 19
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 3 10
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 45
Acetylcholinesterase Inhibitor (3-hydroxy-2-methyl-phenyl)-tri... 4 25
Tyrosinase Inhibitor 1-hydroxy-3-(4-nitrophenyl)urea Family 2 2
Sigma non-opioid intracellular receptor 1 ligand 1-[(3-nitroph... 4 2
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 2 1
Quinoxalines Metabolite Quindoxin Family 1 3
N-[[(1S,9aR)-5-methyl-2,3,4,6,7,8,9,9a-octahydro-1H-quinolizin... 1 0


External ID

Functional Category

Molecule Name

CFAMM00291751 CHEMBL470366 Bioactive AGN-PC-077S1E
CFAMM00291766 CHEMBL148484 Bioactive 3-Nitrophenyltrimethylammonium iodide
CFAMM00291747 DNC011941 Investigative Drug 1-(3-Nitro-phenyl)-piperazine

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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