CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3454
Family Name Sodium-dependent serotonin transporter Inhibitor Tefludazine Family
No. of Seeds 8 No. of Other Members 9
Family Centroid CFAMM00291798 Functional Category Investigative Drug
Superfamily Sodium-dependent serotonin transporter Inhibitor Tefludazine Superfamily
Class Class 2776

Cousin Family NamesSeedsMembers
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Dopamine receptor ligand norcamphene derivative Fencamfamine F... 3 41
Amine oxidase [flavin-containing] B Inhibitor Rasagiline Family 2 11
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Substance-P receptor Ligand Orvepitant Family 11 46
Zicronapine family 43 62
Sigma non-opioid intracellular receptor 1 Ligand Dimemorfan Fa... 5 15
Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15
Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphtha... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Sodium-dependent serotonin transporter Inhibitor Irindalone Fa... 16 9
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 5 6
Sigma non-opioid intracellular receptor 1 ligand CHEMBL101300 ... 2 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 7 and Sodium-dependent serotonin ... 5 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 7 1
Vesicular acetylcholine transporter inhibitor (3R,4R)-1-[(3-io... 17 20
D(1A) dopamine receptor and D(2) dopamine receptor ligand Sure... 2 0
D(1A) dopamine receptor and 5-hydroxytryptamine receptor 2A li... 2 0
Transporter and Sodium-dependent serotonin transporter inhibit... 4 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 6 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 12
D(1A) dopamine receptor and D(3) dopamine receptor ligand 2-[4... 1 0
Histamine H3 receptor ligand 2-benzyl-4-[4-(2-pyrrolidin-1-yle... 8 4
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Sodium-dependent serotonin transporter and Transporter inhibit... 2 8
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Histamine H3 receptor ligand 1-[4-[4-(pyrrolidin-1-ylmethyl)ph... 4 2
Sigma non-opioid intracellular receptor 1 ligand [(2R)-1,4-dib... 1 4
Melanocortin receptor 4 ligand 1-[3-[2-(4-tert-butylphenyl)phe... 1 3
Mu-type opioid receptor ligand CHEMBL2373396 family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00291813 CHEMBL343078 Bioactive AGN-PC-01ZH7Q
CFAMM00291812 CHEMBL1744116 Bioactive (Z)-but-2-enedioic acid;2-[4-[3-(4-fluorophenyl)-5-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl]ethanol
CFAMM00291804 CHEMBL1203891 Bioactive 4-[4-[6-fluoro-3-(4-fluorophenyl)-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl]butan-1-ol;dihydrochloride
CFAMM00291803 CHEMBL1204350 Bioactive 2-[4-[3-(4-fluorophenyl)-6-methyl-2,3-dihydro-1H-inden-1-yl]piperazin-1-yl]ethanol;dihydrochloride
CFAMM00291810 CHEMBL95636 Bioactive Tefludazine
CFAMM00291815 CHEMBL140189 Bioactive AGN-PC-01ZH7P
CFAMM00291798 DNC011951 Investigative Drug TEFLUDAZINE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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