CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3461
Family Name cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-specific 3',5'-cyclic phosphodiesterase 4B Inhibitor Benzyl-(2-thiophen-2-yl-quinazolin-4-yl)-amine Family
No. of Seeds 4 No. of Other Members 22
Family Centroid CFAMM00291920 Functional Category Investigative Drug
Superfamily Peptide deformylase, mitochondrial and cAMP-specific 3',5'-cyclic phosphodiesterase 4B Binder Superfamily
Class Class 1843

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
Transient receptor potential cation channel subfamily V member... 15 457
5-hydroxytryptamine receptor 3A Ligand DDP-225 Family 1 7
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Serine/threonine-protein kinase B-raf Inhibitor GSK2118436 Family 5 19
Aurora kinase A Inhibitor ABT-348 Family 20 49
PF-3758309 family 1 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CRA1000 Family 4 39
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
5-hydroxytryptamine receptor Ligand Sl65.0472 Family 2 16
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(1-(4-thi... 3 36
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Vascular endothelial growth factor receptor 2 Ligand 3-(4-amin... 2 5
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 3 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... 18 21
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Corticotropin-releasing factor receptor 1 Ligand N-mesityl-6-m... 3 2
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 8
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
5-hydroxytryptamine receptor 6 ligand AGN-PC-03P3TZ family 6 88
5-hydroxytryptamine receptor 6 ligand AGN-PC-031XQS family 1 1
Vascular endothelial growth factor receptor 2 and Mast/stem ce... 10 27
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Adenosine kinase inhibitor SureCN8183719 family 2 3
Epidermal growth factor receptor ligand AGN-PC-07C2E2 family 7 6
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Cell division cycle 7-related protein kinase inhibitor AGN-PC-... 6 6
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 1 1
Histamine H4 receptor ligand 8-chloro-4-[(3R)-3-(methylamino)p... 3 10
Histamine H4 receptor ligand 8-bromo-4-(4-methylpiperazin-1-yl... 2 1
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Ketohexokinase inhibitor 4-N-(2-methylsulfanylphenyl)-2-pipera... 6 23
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 12 7
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0760... 4 0
Growth hormone secretagogue receptor type 1 ligand SureCN63605... 5 7
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 2-[4... 5 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 5 0
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor CDK Inhibito... 8 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Protein-cysteine N-palmitoyltransferase porcupine inhibitor 2-... 5 2
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Transient receptor potential cation channel subfamily V member... 1 0
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
Dihydrofolate reductase inhibitor WR 158122 family 1 0
Prostaglandin G/H synthase 2 inhibitor 6-ethoxy-2-(4-methylsul... 5 1
Prostaglandin G/H synthase 2 inhibitor 2-(4-methylsulfonylphen... 1 0
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 1
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Growth hormone secretagogue receptor type 1 ligand AGN-PC-00CN... 1 2
Vascular endothelial growth factor receptor 2 ligand Thienopyr... 2 2
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Histamine H4 receptor and Histamine H1 receptor ligand 6-chlor... 1 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 5 0
Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... 7 2
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
D(4) dopamine receptor and D(2) dopamine receptor ligand 3-(1-... 1 0
Vascular endothelial growth factor receptor 2 and Insulin rece... 2 0
Aurora kinase A and Vascular endothelial growth factor recepto... 1 1
Lysophosphatidic acid receptor 2 ligand N-[(2S)-1-[4-(3,4-dich... 2 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00291931 CHEMBL400298 Bioactive (1S,3S)-1-N-(4-methylquinolin-2-yl)-3-N-(thiophen-3-ylmethyl)cyclohexane-1,3-diamine
CFAMM00291909 CHEMBL271104 Bioactive 2-(4-methylsulfonylphenyl)-6-propan-2-yl-N-(thiophen-2-ylmethyl)pyrimidin-4-amine
CFAMM00291920 DNC011965 Investigative Drug Benzyl-(2-thiophen-2-yl-quinazolin-4-yl)-amine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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