CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3465
Family Name Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 Inhibitor 2-benzyl-1,2-dihydro-indazol-3-one Family
No. of Seeds 9 No. of Other Members 7
Family Centroid CFAMM00291967 Functional Category Investigative Drug with Natural Product
Superfamily Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 Binder Superfamily
Class Class 1330

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Voltage-gated sodium channel Ligand Oxcarbazepine Family 1 4
Serum albumin Inhibitor Ebselen Family 3 62
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Motilin receptor Ligand GSK962040 Family 30 457
Poly [ADP-ribose] polymerase 1 Inhibitor BSI-201 Family 3 16
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Dual specificity mitogen-activated protein kinase kinase Inhib... 8 4
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dion... 10 35
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Transient receptor potential cation channel subfamily V member... 6 33
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 1 9
Transient receptor potential cation channel subfamily V member... 1 5
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor Benz... 3 12
Poly [ADP-ribose] polymerase 1 Inhibitor 5-aminoisoquinolin-1(... 2 8
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 12
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 9h-bet... 1 1
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(3-cyanophe... 7 5
Myeloperoxidase Inhibitor 4-aminobenzoic Acid Hydrazide Family 1 3
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 53
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Vascular endothelial growth factor receptor 2 ligand 1-[4-(3-o... 1 1
D-alanyl-D-alanine carboxypeptidase and Penicillin-binding pro... 1 0
3-prop-2-enyl-1H-quinolin-4-one NP 6-amino-2-methylquinolin-4-... 5 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00291957 DNC011981 Investigative Drug 2-Phenethyl-1,2-dihydro-indazol-3-one
CFAMM00291967 DNC011996 Investigative Drug 2-Benzyl-1,2-dihydro-indazol-3-one
CFAMM00291949 DNC012011 Investigative Drug 1-Benzyl-1,2-dihydro-indazol-3-one
CFAMM00291966 DNC011993 Investigative Drug 1-Methyl-1,2-dihydro-indazol-3-one
CFAMM00291962 DNC012004 Investigative Drug 2-(3-Phenyl-propyl)-1,2-dihydro-indazol-3-one
CFAMM00291959 DNC012007 Investigative Drug 2-Phenyl-1,2-dihydro-indazol-3-one
CFAMM00291952 DNC011979 Investigative Drug 2-(4-Phenyl-butyl)-1,2-dihydro-indazol-3-one
CFAMM00291958 DNC012003 Investigative Drug 2-Methyl-1,2-dihydro-indazol-3-one
CFAMM00291951 DNC011974 Investigative Drug 1,2-Dihydro-indazol-3-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24638 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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