CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID347
Family Name Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 Family
No. of Seeds 6 No. of Other Members 70
Family Centroid CFAMM00188387 Functional Category Investigative Drug
Superfamily Serine/threonine-protein kinase mTOR and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Binder Superfamily 2
Class Class 850

Cousin Family NamesSeedsMembers
Prostaglandin G/H synthase 2 Inhibitor Niflumic Acid Family 7 119
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
AP26113 family 16 90
Fibroblast growth factor receptor 1 Ligand BGJ398 Family 3 6
Casein kinase II subunit alpha Inhibitor CX-4945 Family 1 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Mitogen-activated protein kinase 8 Inhibitor 2-(2-phenoxypyrim... 12 30
Hepatocyte growth factor receptor Ligand BMS-777607 Family 10 1
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Mitogen-activated protein kinase 14 Inhibitor Pamapimod Family 15 7
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 11
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 0
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Vascular endothelial growth factor receptor 2 ligand 1-[4-[6-a... 11 13
Glycogen synthase kinase-3 beta inhibitor 6-[(2S)-2-(2-methoxy... 1 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 9
Wee1-like protein kinase and ALK tyrosine kinase receptor liga... 1 9
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
ALK tyrosine kinase receptor and Insulin-like growth factor 1 ... 1 4
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(2,6-di... 6 5
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
Melanocortin receptor 4 ligand N-[(2R)-3-(2,4-dichlorophenyl)-... 2 2
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 1 2
Aurora kinase A inhibitor Bisanilinopyrimidine, 6j family 2 1
Aurora kinase A inhibitor 4-[[4-(2-chloroanilino)pyrimidin-2-y... 1 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0Z0U... 2 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Ephrin type-A receptor 3 and Tyrosine-protein kinase Fgr ligan... 1 3
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Dihydrofolate reductase inhibitor 5-[[4-(2,4-dichlorophenyl)-6... 1 0
Tyrosine-protein kinase Lck inhibitor SureCN374434 family 1 1
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-071H3F fa... 3 0
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(2,6... 1 1
Hepatocyte growth factor receptor ligand [4-[6-amino-5-[1-(2,6... 5 1
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00188405 CHEMBL323405 Bioactive AC1NS3B4
CFAMM00188347 DNC009910 Investigative Drug PD-0173958
CFAMM00188346 DNC009911 Investigative Drug PD-0179483
CFAMM00188404 DNC000727 Investigative Drug Heparin-Cantithrombin III
CFAMM00188361 DNC009907 Investigative Drug PD-0166326
CFAMM00188387 DNC001100 Investigative Drug PD166285

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27432 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543