CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3475
Family Name Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-aminobutyric acid receptor subunit beta-2 Ligand 2-thiophen-2-yl-3h-imidazo[4,5-c]quinoline Family
No. of Seeds 6 No. of Other Members 55
Family Centroid CFAMM00292136 Functional Category Investigative Drug
Superfamily Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor Binder Superfamily
Class Class 2000

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Toll-like receptor 7 Ligand Imiquimod Family 3 237
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Fumarate reductase flavoprotein subunit Inhibitor Thiabendazol... 3 20
Histamine H1 receptor Ligand Mizolastine Family 14 603
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Aurora kinase B and Aurora kinase A Inhibitor CYC116 Family 16 135
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 15 457
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 53
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
Aurora kinase A Inhibitor ABT-348 Family 20 49
PF-4217903 family 14 65
PF-3758309 family 1 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Tryptase Inhibitor Babim Family 12 90
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Tyrosine kinase Inhibitor PKI166 Family 17 198
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
5-hydroxytryptamine receptor Ligand Sl65.0472 Family 2 16
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(1-(4-thi... 3 36
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Methionine aminopeptidase 2 Inhibitor 2-(pyridin-2-yl)-1h-benz... 6 19
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Adenosine receptor A1 Ligand Phenyl-(9-phenyl-9h-purin-6-yl)-a... 7 12
Mitogen-activated protein kinase 14 Inhibitor 6-phenylsulfanyl... 4 6
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Mitogen-activated protein kinase 14 Inhibitor 9-benzyl-6-pheny... 5 33
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
TGF-beta receptor type-1 Ligand 4-pyridin-2-yl-5-quinolin-4-yl... 4 23
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(4-e... 2 5
Adenosine receptor A3 Ligand 2-(4-nitro-1h-benzo[d]imidazol-2-... 2 12
Metabotropic glutamate receptor 5 Ligand 4-(4-chlorophenylthio... 4 17
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Vascular endothelial growth factor receptor 2 Ligand 3-(4-amin... 2 5
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 4 23
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 3 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2
Indoleamine 2,3-dioxygenase 1 Inhibitor 3-(4h-imidazol-4-yl)be... 6 3
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-264... 6 32
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(thiophen-... 2 1
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-bromobenzyl... 3 0
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Peptide deformylase, mitochondrial Inhibitor 6-phenylsulfanylm... 2 3
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
NADH-ubiquinone oxidoreductase chain 3 Inhibitor 6-thiophen-3-... 2 0
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
Deoxycytidine kinase inhibitor AGN-PC-07Z9B3 family 2 7
Mitogen-activated protein kinase 14 inhibitor 6-[3-amino-5-(2-... 4 9
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 20
Potassium voltage-gated channel subfamily H member 2 and Neuro... 2 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 4
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Tyrosine-protein kinase JAK2 and Potassium voltage-gated chann... 1 0
Bombesin receptor subtype-3 ligand (2R)-1-[4-[2-[5-(2,2-dimeth... 1 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Sterol O-acyltransferase 1 inhibitor 1-(2,4-difluorophenyl)-3-... 8 90
5-hydroxytryptamine receptor 6 ligand AGN-PC-03P3TZ family 6 88
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Adenosine receptor A3 ligand 5-butyl-8-(4-methylsulfanylphenyl... 2 4
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 1 inhibi... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Vascular endothelial growth factor receptor 2 and Mast/stem ce... 10 27
5-hydroxytryptamine receptor 6 ligand 6-chloro-5-[1-(1-methylp... 9 0
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Adenosine receptor A1 and Adenosine receptor A2b ligand SureCN... 1 0
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Inosine-5'-monophosphate dehydrogenase and Nuclear receptor RO... 2 9
Pol polyprotein and Reverse transcriptase/RNaseH inhibitor AC1... 6 11
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Adenosine kinase inhibitor SureCN8183719 family 2 3
Amine oxidase [flavin-containing] B inhibitor 4-(4-fluoropheny... 3 4
Epidermal growth factor receptor ligand AGN-PC-07C2E2 family 7 6
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Cell division cycle 7-related protein kinase inhibitor AGN-PC-... 6 6
Platelet-activating factor receptor ligand Foropafant family 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 18
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Metabotropic glutamate receptor 4 and Potassium voltage-gated ... 2 15
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Cyclin-dependent kinase 5 and G1/S-specific cyclin-E1 inhibito... 1 1
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Cyclin-dependent kinase 1 inhibitor 4-[[4-(3H-benzimidazol-5-y... 1 0
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
TGF-beta receptor type-1 ligand 6-[(5E)-5-(4-methyl-3H-1,3-thi... 22 9
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
3-phosphoinositide-dependent protein kinase 1 and MAP kinase-a... 1 5
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Ketohexokinase inhibitor 4-N-(2-methylsulfanylphenyl)-2-pipera... 6 23
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 12 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 1
Neuropeptide Y receptor type 5 and Cytochrome P450 1A2 ligand ... 8 19
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152412 family 8 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-N-[... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 1
Neuropeptide Y receptor type 5 ligand 2-(3-phenylpiperidin-1-y... 6 2
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 3 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Somatostatin receptor type 3 and Somatostatin receptor type 4 ... 5 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206614 family 2 0
Mitogen-activated protein kinase 14 inhibitor 6-[2-(2,6-difluo... 3 0
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Tyrosine-protein kinase JAK1 and Aurora kinase A inhibitor CHE... 2 0
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 16 0
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 7 7
Methionine aminopeptidase 2 inhibitor SureCN5373581 family 6 0
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 5 3
Glucocorticoid receptor ligand 3-(1H-indol-5-yl)-2,2-dimethyl-... 2 7
Tyrosine-protein kinase ITK/TSK and Tyrosine-protein kinase Lc... 2 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Trans-2-enoyl-ACP reductase II inhibitor AGN-PC-01LWZK family 3 0
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 0
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 1 0
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 1 0
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 1 0
Epidermal growth factor receptor and Vascular endothelial grow... 2 1
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Epidermal growth factor receptor and Vascular endothelial grow... 3 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 4 0
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Histamine H4 receptor and Histamine H1 receptor ligand 6-chlor... 1 0
Mitogen-activated protein kinase 14 inhibitor SureCN828349 family 1 0
Alpha-1A adrenergic receptor and Alpha-2A adrenergic receptor ... 1 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Gonadotropin-releasing hormone receptor ligand AGN-PC-00AWCA f... 1 0
5-hydroxytryptamine receptor 3A ligand AGN-PC-077D8K family 3 1
Transient receptor potential cation channel subfamily V member... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 5 0
Histamine H3 receptor ligand 5-(3-bromophenyl)-2-[2-(1H-imidaz... 2 2
D(4) dopamine receptor and D(2) dopamine receptor ligand 3-(1-... 1 0
Bombesin receptor subtype-3 ligand AGN-PC-07ZCL7 family 1 0
Vascular endothelial growth factor receptor 2 and Insulin rece... 2 0
Cytochrome P450 11B1, mitochondrial and Cytochrome P450 11B2, ... 1 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-0763DE ... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Lysophosphatidic acid receptor 2 ligand N-[(2S)-1-[4-(3,4-dich... 2 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1
Acyl-CoA:cholesterol acyltransferase and Sterol O-acyltransfer... 3 2
Cyclooxygenase 2 and Prostaglandin G/H synthase 1 inhibitor Su... 2 1
Corticotropin-releasing factor receptor 1 ligand 2-[1-[1-[4-ni... 2 1
Glycogen synthase kinase-3 beta inhibitor pyrazolopyrimidine d... 1 0
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VN4 family 1 0
Glutaminyl-peptide cyclotransferase inhibitor 2-(3H-benzimidaz... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00292169 CHEMBL421747 Bioactive AGN-PC-0028YJ
CFAMM00292132 CHEMBL1079538 Bioactive AGN-PC-07ZBM9
CFAMM00292131 CHEMBL100148 Bioactive AGN-PC-000PKN
CFAMM00292164 CHEMBL1078906 Bioactive AGN-PC-00AUKO
CFAMM00292136 DNC012024 Investigative Drug 2-Thiophen-2-yl-3H-imidazo[4,5-c]quinoline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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