CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID349
Family Name Bacterial outer membrane Inhibitor HKI-9924129 Family
No. of Seeds 19 No. of Other Members 85
Family Centroid CFAMM00188520 Functional Category Investigative Drug
Superfamily Bacterial outer membrane Inhibitor HKI-9924129 Superfamily
Class Class 1053

Cousin Family NamesSeedsMembers
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Prothrombin Inhibitor Dabigatran Family 7 182
Transient receptor potential cation channel subfamily V member... 16 295
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Mast/stem cell growth factor receptor Kit and Vascular endothe... 4 47
Translocator protein Inhibitor Emapunil Family 7 89
Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family 2 41
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
Class II cytokine receptor Ligand IL-10 Family 7 45
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 6 Inhibi... 2 3
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Adenosine receptor A1 Ligand N-(4,6-diphenylpyrimidin-2-yl)ben... 4 8
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Potassium voltage-gated channel subfamily H member 2 Ligand Be... 22 56
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 6-(4-... 3 6
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 4
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 12
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Nicotinamide phosphoribosyltransferase inhibitor 4-[(7-chloro-... 6 4
Serine/threonine-protein kinase mTOR and RAC-alpha serine/thre... 3 3
RAC-alpha serine/threonine-protein kinase inhibitor (2S)-3-ami... 2 0
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Cell division cycle 7-related protein kinase and Cyclin-depend... 2 9
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 9 31
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
G1/S-specific cyclin-D1 and G1/S-specific cyclin-D3 inhibitor ... 6 3
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 2
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 2 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(4-chlo... 11 2
Hepatocyte growth factor receptor and Insulin receptor ligand ... 4 15
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 14
C-X-C chemokine receptor type 3 ligand SureCN13205646 family 4 0
Coagulation factor X and Kallikrein-1 inhibitor SureCN890858 f... 5 6
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
Coagulation factor X inhibitor AGN-PC-078Y3A family 4 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 1 0
ALK tyrosine kinase receptor and Insulin receptor ligand N-[(1... 3 6
Nicotinamide phosphoribosyltransferase inhibitor 4-[[(7-chloro... 1 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
G1/S-specific cyclin-E2 and G1/S-specific cyclin-E1 inhibitor ... 5 10
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-0733AC family 7 29
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Cell division cycle 7-related protein kinase and Dual specific... 3 1
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 8 5
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-2-[(2,6-di... 6 5
Substance-P receptor ligand 2-[3,5-bis(trifluoromethyl)phenyl]... 3 1
ALK tyrosine kinase receptor and Insulin receptor ligand 2-[[5... 1 0
Corticotropin-releasing factor receptor 1 ligand 4-[(1R)-1-cyc... 5 6
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Melanocortin receptor 4 ligand N-[(2R)-3-(2,4-dichlorophenyl)-... 2 2
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 3 0
cAMP-dependent protein kinase catalytic subunit beta and cAMP-... 2 9
Beta-secretase 1 and Beta-secretase 2 inhibitor 5-[(1R)-3-amin... 8 1
Aurora kinase A inhibitor Bisanilinopyrimidine, 6j family 2 1
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 11 2
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 2 0
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 6 3
P2X purinoceptor 7 inhibitor SureCN1635928 family 4 4
P2X purinoceptor 7 inhibitor SureCN113576 family 2 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Tyrosine-protein kinase receptor TYRO3 and Mitogen-activated p... 3 7
G-protein coupled bile acid receptor 1 ligand 2-(ethylamino)-6... 5 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor (3R)-... 4 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0Z0U... 2 0
Non-receptor tyrosine-protein kinase TYK2 ligand SureCN1298914... 3 0
Non-receptor tyrosine-protein kinase TYK2 ligand SureCN3514789... 1 0
Epidermal growth factor receptor ligand N-[3-[2-(4-morpholin-4... 2 2
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Macrophage colony-stimulating factor 1 receptor and Mast/stem ... 27 4
Coagulation factor X inhibitor 5-bromo-N-(5-chloropyridin-2-yl... 1 1
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 2
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Cathepsin S and Cathepsin K inhibitor AGN-PC-00CD7W family 5 5
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Coagulation factor X inhibitor N-[2-[(5-chloropyridin-2-yl)sul... 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Epidermal growth factor receptor ligand (E)-1-[4-(3-bromoanili... 9 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 7 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
P2X purinoceptor 7 inhibitor N-[1-[(Z)-[(cyanoamino)-(quinolin... 3 3
Transient receptor potential cation channel subfamily V member... 3 2
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
Poly [ADP-ribose] polymerase 1 inhibitor Piperazine analogue, ... 4 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Potassium ... 1 0
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-071H3F fa... 3 0
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 16 3
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 1
Melanin-concentrating hormone receptor 1 and Alpha-2A adrenerg... 1 0
LIM domain kinase 2 inhibitor 3-[[(cyanoamino)-[(2S)-2-methyl-... 6 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R96X family 7 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-[(2,6... 1 1
Tyrosine-protein kinase ABL1 inhibitor (3aS,4S,6aR)-4-[5-[3-[[... 1 0
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 inhibi... 3 7
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 0
Cannabinoid receptor 2 ligand SureCN13503317 family 7 7
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 2 0
Calpain-1 catalytic subunit inhibitor 2,6-dichloro-N-[(2S)-3,4... 1 0
Glycogen synthase kinase-3 beta inhibitor SureCN13987027 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00188535 CHEMBL1223343 Bioactive 2-[(3-aminophenyl)methylamino]-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7-one
CFAMM00188518 CHEMBL419360 Bioactive [[4-[[6-(2,6-dichlorophenyl)-8-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]phenyl]-hydroxyphosphoryl]methylphosphonic acid
CFAMM00188533 CHEMBL1221411 Bioactive 2-amino-N-[3-[[6-(2,6-dichlorophenyl)-8-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]phenyl]acetamide
CFAMM00188445 CHEMBL421024 Bioactive [[4-[[6-(2,6-dichlorophenyl)-8-[3-(dimethylamino)propyl]-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]phenyl]-hydroxyphosphoryl]methylphosphonic acid
CFAMM00188466 DNC009909 Investigative Drug PD-0173956
CFAMM00188483 DNC009908 Investigative Drug PD-0173952
CFAMM00188520 DNC000735 Investigative Drug HKI-9924129
CFAMM00188513 DNC006871 Investigative Drug PD-0173955

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24631 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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