CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFID3498
Family Name Reverse transcriptase Inhibitor UK-129485 Family
No. of Seeds 23 No. of Other Members 221
Family Centroid CFAMM00292623 Functional Category Investigative Drug with Natural Product
Superfamily Reverse transcriptase Inhibitor UK-129485 Superfamily
Class Class 1696

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Histamine H1 receptor Ligand Mepyramine Family 5 65
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
Insulin-like growth factor 1 receptor Ligand AEW-541 Family 12 140
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
AP26113 family 16 90
SB1518 family 7 103
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Histamine H3 receptor Ligand 4-(3-phenoxy-propyl)-1h-imidazole... 26 142
5-hydroxytryptamine receptor 3A and Alpha-2A adrenergic recept... 31 24
RAC-gamma serine/threonine-protein kinase Inhibitor GSK690693 ... 16 27
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Tissue-type plasminogen activator Inhibitor N-(7-benzyloxy-iso... 4 37
Cyclin-dependent kinase 2 Inhibitor 6-cyclohexylmethyloxy-2-(4... 2 11
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Methylated-DNA--protein-cysteine methyltransferase Inhibitor 6... 4 5
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Serine/threonine-protein kinase Chk2 Inhibitor 5-nitro-2-(4-ph... 6 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Metabotropic glutamate receptor 5 Ligand (3-ethoxy-pyridin-2-y... 3 12
Oestrogen receptor and Estrogen receptor beta Ligand 4-(2-phen... 2 9
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 37
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
D(4) dopamine receptor Ligand A-425444 Family 2 10
Aromatase Inhibitor 4-((1h-imidazol-1-yl)methyl)-2h-chromen-2-... 3 69
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
Oxytocin receptor and Vasopressin V1a receptor Ligand PF-32741... 4 36
Protein farnesyltransferase subunit beta Inhibitor A-313326 Fa... 85 149
Platelet-derived growth factor receptor alpha and Platelet-der... 3 18
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
5-hydroxytryptamine receptor 1A Ligand CP-293019 Family 9 24
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 13 15
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Metabotropic glutamate receptor 1 Ligand 4-(cyclohexyloxy)quin... 1 4
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Platelet-derived growth factor receptor beta and Platelet-deri... 2 19
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 2 6
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Aurora kinase A inhibitor SureCN208325 family 1 5
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
Proto-oncogene tyrosine-protein kinase Src and Cyclin-dependen... 2 1
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 16
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 18
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Corticotropin-releasing factor receptor 1 ligand AGN-PC-068CC4... 20 7
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Cathepsin S and Cathepsin K inhibitor AGN-PC-07YOWS family 4 6
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Aurora kinase A inhibitor SureCN761545 family 2 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 10 54
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 7 0
Extracellular calcium-sensing receptor ligand SureCN2972008 fa... 4 1
Heat shock protein HSP 90-alpha inhibitor 3-[2-amino-4-chloro-... 7 2
Adenosine receptor A3 and Adenosine receptor A2a ligand 4-(5-b... 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threon... 1 1
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Translocator protein inhibitor AGN-PC-080ILF family 9 3
Casein kinase I isoform delta and Mitogen-activated protein ki... 3 18
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
Dual specificity protein kinase CLK1 and Dual specificity prot... 2 14
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Translocator protein inhibitor SureCN6906757 family 3 2
Survival motor neuron protein inhibitor CHEMBL1379159 family 1 10
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 10
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 3
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... 1 4
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 6
Neuropeptide Y receptor type 1 ligand 1-[3-[1-(cyclohexylmethy... 15 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 5 2
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
Tyrosine-protein kinase JAK2 inhibitor 5-(3-methoxyphenyl)-N-[... 2 11
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family 3 13
Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Cathepsin S and Cathepsin K inhibitor AGN-PC-07YOWR family 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 3 4
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 4
Melanin-concentrating hormone receptor 1 ligand SureCN3334861 ... 1 3
Ephrin type-B receptor 4 ligand SureCN5131922 family 4 0
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 2 0
Cholecystokinin receptor type A ligand AGN-PC-0A9ULH family 8 8
Sodium/glucose cotransporter 2 inhibitor AGN-PC-0A9TPG family 2 0
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Voltage-dependent calcium channel subunit alpha-2/delta-1 and ... 9 15
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 9 10
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Insulin-like growth factor 1 receptor and Potassium voltage-ga... 2 2
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Corticotropin-releasing factor receptor 1 ligand CHEMBL1819076... 2 0
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 0
Hepatocyte growth factor receptor ligand 4-[(6-phenyl-[1,2,4]t... 3 6
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 3 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor 2-[4-[... 2 6
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 3
Toll-like receptor 7 ligand 4-amino-1-[[6-(2-pyrrolidin-1-ylet... 2 5
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 5 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 4 2
Metabotropic glutamate receptor 5 ligand SureCN4297614 family 2 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Cathepsin K and Cathepsin L1 inhibitor CHEBI:43424 family 2 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 16 3
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 7 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 24 5
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 3 0
Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-(... 4 3
Receptor tyrosine-protein kinase erbB-2 ligand 2-[2-[4-[3-chlo... 4 5
Tyrosine-protein kinase JAK2 inhibitor N-[3-chloro-4-(4-methyl... 2 1
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 3 1
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-met... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
ALK tyrosine kinase receptor ligand CHEMBL1946804 family 3 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 5 8
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Adenosine kinase inhibitor (2R,3R,4R)-2-[4-(2,3-dihydro-1,4-be... 5 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 4 4
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-07... 1 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN6387344 f... 6 11
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Dual specificity protein kinase TTK inhibitor 2-[1-[4-[[6-(cyc... 8 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Vascular endothelial growth factor receptor 2 and Vascular end... 4 2
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Xanthine dehydrogenase/oxidase inhibitor 4-[[4-(2-aminopyrimid... 3 16
Corticotropin-releasing factor receptor 1 ligand 8-(2-chloro-4... 13 1
Lysine--tRNA ligase inhibitor 4-[[[2-(2-piperazin-1-ylpyridin-... 2 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 25 2
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
D(3) dopamine receptor and D(2) dopamine receptor ligand Piper... 3 14
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 6 13
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
ALK tyrosine kinase receptor and Nucleophosmin ligand N-[2-[2-... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 18 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Eukaryotic translation initiation factor 2-alpha kinase 3 inhi... 1 1
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 1 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
Estrogen receptor and Estrogen receptor beta ligand 4-[3-[4-(2... 1 0
Rho-associated protein kinase 1 inhibitor SureCN4716133 family 2 2
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 4 2
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 1
Glucose-dependent insulinotropic receptor ligand (2R)-2-[1-(5-... 4 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Metabotropic glutamate receptor 2 ligand 8-chloro-3-(cycloprop... 6 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
CGMP-dependent protein kinase inhibitor 1-[2-(4-fluorophenyl)-... 1 4
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Transient receptor potential cation channel subfamily V member... 2 4
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4463897 f... 3 2
Neuropeptide Y receptor type 5 ligand 6-ethylsulfonyl-2-(4-phe... 4 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Motilin receptor ligand SureCN2012437 family 4 0
Histamine H3 receptor and Potassium voltage-gated channel subf... 1 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
cGMP-dependent 3',5'-cyclic phosphodiesterase inhibitor SureCN... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 12 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
G1/S-specific cyclin-E1 and Cyclin-dependent kinase 2 inhibito... 1 4
Phosphatidylinositol 4-kinase beta inhibitor (4E)-2-fluoro-4-[... 1 3
Diacylglycerol O-acyltransferase 1 inhibitor 4-[5-[5-(1H-benzi... 7 1
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Adenosine receptor A2a ligand 8-(3-fluorophenyl)-3-[2-[4-[4-(2... 5 0
Cyclin-dependent kinase 1 inhibitor N-[[5-[(3Z)-3-[4-(methoxym... 3 7
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 9 2
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 2
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 4 3
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 2 2
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Histamine H1 receptor ligand N-[6-[2-[(4-methoxyphenyl)methyl-... 2 1
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 2
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 1
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074EV8... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1
Dihydrofolate reductase and Dihydrofolate reductase type 1 inh... 8 1
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 1 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Glucagon receptor ligand SureCN2647807 family 3 7
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-07... 1 0
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Transient receptor potential cation channel subfamily V member... 18 1
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Type-1 angiotensin II receptor ligand AGN-PC-00FH82 family 1 1
Proto-oncogene tyrosine-protein kinase Src inhibitor SureCN136... 1 0
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Insulin-like growth factor 1 receptor ligand SureCN310120 family 10 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Peroxisome proliferator-activated receptor gamma ligand (2S)-2... 8 0
Oxytocin receptor and Vasopressin V1b receptor ligand AGN-PC-0... 1 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 7 5
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
Cholecystokinin receptor type A ligand SureCN3132309 family 11 0
Cholecystokinin receptor type A ligand AGN-PC-077KXF family 2 0
Metabotropic glutamate receptor 2 ligand 2-[[(1R,5S)-6-[(2,5-d... 2 3
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Nociceptin receptor and Delta-type opioid receptor ligand 2-[3... 2 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor AGN-PC... 2 0
Acyl-CoA desaturase 1 inhibitor Pyridazine, 3-[4-(2-ethylpheno... 4 2
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 7 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4D inhibitor Sure... 2 6
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Epidermal growth factor receptor ligand 4-Anilinoquinazoline d... 2 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-07ZH03... 1 0
Potassium-transporting ATPase alpha chain 1 and Potassium-tran... 2 11
Sodium channel protein type 5 subunit alpha and Sodium channel... 15 8
Metabotropic glutamate receptor 5 ligand N-[2-[(3-chlorophenyl... 1 4
Metabotropic glutamate receptor 5 ligand AGN-PC-0760YR family 1 0
Delta-type opioid receptor and Kappa-type opioid receptor liga... 2 0
Bifunctional epoxide hydrolase 2 and Arachidonate 5-lipoxygena... 3 0
Metabotropic glutamate receptor 5 ligand 2-[4-(4-fluoro-3-meth... 1 0
Protein kinase C theta type inhibitor SureCN3953579 family 2 1
Corticotropin-releasing factor receptor 1 ligand N-[(1R,2S)-2-... 3 0
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8919280 f... 23 18
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 2 0
Tryptophan 5-hydroxylase 1 inhibitor (2S)-2-amino-3-[4-[5-[(3,... 1 3
Nuclear receptor ROR-gamma and Cytochrome P450 3A4 ligand NCGC... 1 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 3 35
Metabotropic glutamate receptor 5 ligand AGN-PC-09QKEE family 1 0
Aromatase inhibitor AGN-PC-0A9UOR family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00292715 CHEMBL2165027 Bioactive 4-[5-(methoxymethyl)-2-[(6-methoxypyridin-3-yl)amino]pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
CFAMM00292772 CHEMBL95265 Bioactive AGN-PC-074RYQ
CFAMM00292657 CHEMBL99151 Bioactive 2-ethyl-3-(1-methoxypentan-3-yl)-7-[6-methoxy-2-(trifluoromethyl)pyridin-3-yl]imidazo[4,5-b]pyridine
CFAMM00292650 CHEMBL99286 Bioactive AGN-PC-074RYT
CFAMM00292642 CHEMBL2165031 Bioactive 4-[2-[(6-methoxypyridin-3-yl)amino]-5-(4-methylpiperazin-1-yl)pyridin-3-yl]-6-methyl-1,3,5-triazin-2-amine
CFAMM00292721 CHEMBL1916093 Bioactive CHEMBL1916093
CFAMM00292595 CHEMBL211590 Bioactive AGN-PC-00DIKE
CFAMM00292669 CHEMBL420442 Bioactive AGN-PC-01NQ4K
CFAMM00292691 CHEMBL99239 Bioactive AGN-PC-074RYR
CFAMM00292621 CHEMBL112011 Bioactive SureCN6291771
CFAMM00292776 CHEMBL1085406 Bioactive AGN-PC-07YHOS
CFAMM00292791 CHEMBL316624 Bioactive 3-butan-2-yl-2-ethyl-7-[6-methoxy-2-(trifluoromethyl)pyridin-3-yl]imidazo[4,5-b]pyridine
CFAMM00292648 CHEMBL210283 Bioactive AGN-PC-00D1NB
CFAMM00292661 CHEMBL100157 Bioactive 2-ethyl-7-[6-methoxy-2-(trifluoromethyl)pyridin-3-yl]-3-pentan-2-ylimidazo[4,5-b]pyridine
CFAMM00292775 CHEMBL98093 Bioactive AGN-PC-074RZ0
CFAMM00292787 CHEMBL431287 Bioactive 3-(1-cyclopropylpropyl)-2-ethyl-7-(6-methoxy-2-methylpyridin-3-yl)imidazo[4,5-b]pyridine
CFAMM00292731 CHEMBL211118 Bioactive AGN-PC-00D2KB
CFAMM00292618 CHEMBL328163 Bioactive 3-(1-cyclopropylpropyl)-2-ethyl-7-[6-methoxy-2-(trifluoromethyl)pyridin-3-yl]imidazo[4,5-b]pyridine
CFAMM00292694 CHEMBL328851 Bioactive AGN-PC-074S0V
CFAMM00292623 DNC012116 Investigative Drug UK-129485

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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