CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID35
Family Name Sodium- and chloride-dependent glycine transporter 1 Inhibitor SSR-504734 Family
No. of Seeds 11 No. of Other Members 67
Family Centroid CFAMM00175371 Functional Category Investigative Drug
Superfamily Substance-K receptor and Substance-P receptor Ligand DNK-333 Superfamily
Class Class 496

Cousin Family NamesSeedsMembers
Noradrenergic re-uptake and Serotonin re-uptake inhibitor phen... 18 41
Vasopressin V1a receptor Ligand Felypressin Family 12 820
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Sodium channel protein type 5 subunit alpha Ligand Indecainide... 2 41
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Amine oxidase [flavin-containing] A Inhibitor Moclobemide Family 5 255
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
Acetylcholinesterase Inhibitor Ambenonium Family 4 71
DNA Binder Procarbazine Family 8 358
Peripheral carotid chemoreceptor Ligand Doxapram Family 4 36
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Neuromedin-K receptor Ligand Osanetant Family 38 192
Substance-P receptor Ligand Orvepitant Family 11 46
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Tumor necrosis factor Inhibitor Talactoferrin Alfa Family 26 131
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
C-C chemokine receptor type 5 Ligand Tak-220 Family 8 56
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Prothrombin Inhibitor D-leucyl-n-(3-chlorobenzyl)-l-prolinamid... 18 168
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 5-(4-chloro-... 10 52
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... 7 13
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Dipeptidyl peptidase 4 Inhibitor 2-(2-chlorophenyl)-2-morpholi... 2 34
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Dipeptidyl peptidase 4 Inhibitor N4-(4-chlorobenzyl)-2,4-diami... 10 22
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Phospholipase D1 Inhibitor Halopemide Family 17 111
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Cathepsin S Inhibitor N-(1-oxobutan-2-yl)-3-(trifluoromethyl)b... 2 10
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Aminopeptidase N Inhibitor 2-benzyl-n1-hydroxy-n3-(4-phenylbut... 5 3
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-3'... 14 11
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand N-(3-... 1 7
Integrin beta-2 and Intercellular adhesion molecule 1 inhibito... 3 18
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 1 1
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 1 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 7 9
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [2... 2 4
Substance-K receptor and Substance-P receptor ligand N-[4-[[4-... 1 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 1 1
C-C chemokine receptor type 5 ligand N-[(1S)-3-[(3aS,6aR)-5-(2... 1 1
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 5 11
Sodium-dependent dopamine transporter and Transporter inhibito... 4 3
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
P2X purinoceptor 7 inhibitor (4S)-N-[(2,4-dichlorophenyl)methy... 16 11
P2X purinoceptor 7 inhibitor (4S)-N-[[2-chloro-3-(trifluoromet... 10 18
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 6
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 3 0
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2,5-dichlor... 3 4
Substance-P receptor ligand AGN-PC-075NUD family 4 1
Shiga toxin 1 variant B subunit and Shiga toxin 1 variant A su... 1 3
Substance-P receptor ligand AGN-PC-075NRR family 2 1
Pyruvate kinase PKM and Huntingtin inhibitor CHEMBL1455935 family 1 3
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 2
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 9 0
Substance-P receptor ligand 1-benzyl-5-(3,4-dichlorophenyl)-5-... 2 0
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Prelamin-A/C and Ras-related protein Rab-9A inhibitor CHEMBL15... 1 7
Substance-K receptor and Substance-P receptor ligand N-[(2Z,3R... 26 4
Neuromedin-K receptor ligand (1S,2R)-1-(3,4-dichlorophenyl)-N-... 8 0
Prothrombin inhibitor AGN-PC-09QJ23 family 2 5
Transporter and Sodium-dependent serotonin transporter inhibit... 4 8
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 7 31
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 7 16
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Vasopressin V1a receptor ligand (2R)-3-(4-chlorophenyl)-2-[[2-... 6 2
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-[... 6 0
Vasopressin V1a receptor ligand N-[(2R)-3-(4-chlorophenyl)-1-(... 1 0
Dipeptidyl peptidase 8 inhibitor (2S)-2-amino-4-[4-[bis(4-fluo... 2 9
Kappa-type opioid receptor ligand 3,4-dichloro-N-[2-[[(1S)-2-[... 1 0
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
Substance-K receptor ligand SureCN3083325 family 4 0
Transporter and Sodium-dependent dopamine transporter inhibito... 6 1
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075C6K ... 3 22
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 3
Sigma non-opioid intracellular receptor 1 ligand 2-(3-bromophe... 5 1
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 9 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 7 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (3R... 6 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 6 3
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
C-C chemokine receptor type 2 ligand (2S)-N-[[3,5-bis(trifluor... 1 0
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Substance-P receptor ligand AGN-PC-073QYE family 6 11
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
Prolyl endopeptidase and Seprase inhibitor [(2R)-1-[2-[(2,5-di... 3 2
C-C chemokine receptor type 2 ligand (1S,3R)-N-[[3-fluoro-5-(t... 22 27
Ceramide glucosyltransferase and Cytochrome P450 3A4 inhibitor... 4 0
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(cyanomethyl)-... 1 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
P2X purinoceptor 7 inhibitor SureCN3726471 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-050YWL family 2 4
P2X purinoceptor 7 inhibitor SureCN3652462 family 5 2
P2X purinoceptor 7 inhibitor SureCN8516206 family 5 1
P2X purinoceptor 7 inhibitor (2S)-N-[[2-chloro-3-(trifluoromet... 3 0
P2X purinoceptor 7 inhibitor (4S)-3-methyl-N-[[2-methyl-3-(tri... 3 0
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 3 0
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Receptor activity-modifying protein 1 and Calcitonin gene-rela... 2 4
P2X purinoceptor 7 inhibitor N-(1-adamantylmethyl)-2-chloro-5-... 3 1
C-C chemokine receptor type 1 ligand 4-chloro-N-[(2R)-1-[(4S)-... 6 3
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 4
Histamine H3 receptor ligand AGN-PC-01WA6E family 10 1
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 6 0
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(3... 2 4
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 2 6
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 3 1
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
Sodium-dependent dopamine transporter and Transporter inhibito... 6 0
Substance-P receptor and Potassium voltage-gated channel subfa... 5 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor methyl ... 6 2
Kappa-type opioid receptor ligand SureCN5629426 family 3 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 20 2
Substance-P receptor ligand SureCN8936495 family 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[ethyl-[2-(4... 1 1
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 9
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 1
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 1
C-C chemokine receptor type 5 ligand N-benzyl-N-[(3R)-1-[(1S,5... 1 3
Muscarinic acetylcholine receptor M3 ligand N-[[4-fluoro-3-[3-... 3 0
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[(3,4-dichlo... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor N-... 1 0
Neuromedin-K receptor and Substance-K receptor ligand AGN-PC-0... 2 0
Aldose reductase inhibitor SureCN8804611 family 2 0
Retinal dehydrogenase 1 and 15-hydroxyprostaglandin dehydrogen... 2 0
Substance-P receptor ligand 1-benzyl-3-[bis(4-chlorophenyl)met... 1 3
Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor N-[(2S)-1-[[... 1 3
C-C chemokine receptor type 2 ligand (2S)-N-[[3,5-bis(trifluor... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 2,6-d... 1 1
Sodium- and chloride-dependent glycine transporter 1 inhibitor... 1 0
Voltage-dependent T-type calcium channel subunit alpha-1H and ... 2 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00175396 CHEMBL1088874 Bioactive N-[2-[[(3R)-1-[2-[1-(2-chlorobenzoyl)piperidin-4-yl]ethyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
CFAMM00175394 CHEMBL1092238 Bioactive N-[2-[[(3R)-1-[2-[4-(2-chlorobenzoyl)piperazin-1-yl]ethyl]pyrrolidin-3-yl]amino]-2-oxoethyl]-3-(trifluoromethyl)benzamide
CFAMM00175429 CHEMBL1628568 Bioactive AGN-PC-00EH1B
CFAMM00175416 CHEMBL76564 Bioactive ST50904748
CFAMM00175413 CHEMBL1939495 Bioactive 2-chloro-N-[(S)-[(2S)-1-methylpiperidin-2-yl]-phenylmethyl]-3-(trifluoromethyl)benzamide
CFAMM00175392 CHEMBL136559 Bioactive AGN-PC-075NUZ
CFAMM00175421 CHEMBL2218168 Bioactive SureCN3658870
CFAMM00175405 CHEMBL138825 Bioactive AGN-PC-075NP7
CFAMM00175376 CHEMBL1628644 Bioactive 2-chloro-N-[phenyl-[1-(tritritiomethyl)piperidin-2-yl]methyl]-3-(trifluoromethyl)benzamide
CFAMM00175371 DPR000113 Investigative Drug SSR-504734

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22645 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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