CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3508
Family Name Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-piperazin-1-yl-quinoline Family
No. of Seeds 5 No. of Other Members 35
Family Centroid CFAMM00292975 Functional Category Investigative Drug
Superfamily Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-piperazin-1-yl-quinoline Superfamily
Class Class 2021

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Benzodiazepine receptor Ligand Midazolam Family 5 160
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Amiloride-sensitive sodium channel subunit alpha Ligand Triamt... 8 98
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Histamine H1 receptor Ligand Mizolastine Family 14 603
Transient receptor potential cation channel subfamily V member... 16 295
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
Transient receptor potential cation channel subfamily V member... 15 457
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
GDC-0349 family 44 77
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
D(4) dopamine receptor Ligand L-745,870 Family 30 205
5-hydroxytryptamine receptor 2B Ligand MT-500 Family 8 39
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Peptide deformylase, mitochondrial Inhibitor 5-chloryl-2,4,6-q... 2 6
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Peptide deformylase, mitochondrial Inhibitor 5-phenethyl-quina... 5 14
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 43 17
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand 3-benz... 1 6
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-amin... 2 30
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Cathepsin K Inhibitor 4-phenyl-6-propylpyrimidine-2-carbonitri... 6 10
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-amin... 4 11
Mitogen-activated protein kinase kinase kinase 8 and Stromelys... 6 53
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 9 24
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Urotensin-2 receptor Ligand Palosuran Family 4 4
Macrophage migration inhibitory factor Inhibitor 1-(2-chloroph... 2 22
Sodium-dependent serotonin transporter Inhibitor 6-nitroquipaz... 18 21
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Metabotropic glutamate receptor 5 Ligand 2-methyl-7-m-tolyl-1,... 5 2
Amine oxidase [flavin-containing] A Inhibitor 3-benzyl-n-(2-mo... 2 3
Amine oxidase [flavin-containing] A Inhibitor 1-(3-(4-chlorobe... 3 12
Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... 2 3
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
5-hydroxytryptamine receptor 3A and D(2) dopamine receptor Lig... 1 0
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 3 9
5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor li... 2 3
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 3 5
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Tyrosine-protein kinase ABL1 and Mitogen-activated protein kin... 1 3
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
Bloom syndrome protein inhibitor SR 57227A family 2 12
Cathepsin K and Potassium voltage-gated channel subfamily H me... 3 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and Thyrotropi... 1 2
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 2
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Dihydrofolate reductase inhibitor AC1LAKWV family 2 0
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand N-(1-... 2 6
Survival motor neuron protein inhibitor CHEMBL1581561 family 1 3
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(4-chlo... 11 2
Prostaglandin D2 receptor ligand N-[2-(2,4-dichlorophenyl)ethy... 1 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Histamine H4 receptor ligand 4-[(3R)-3-(methylamino)pyrrolidin... 7 6
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 1 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Corticotropin-releasing factor receptor 1 ligand 5-(2,4-dichlo... 5 17
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
Corticotropin-releasing factor receptor 1 ligand 8-[butyl(ethy... 2 6
Corticotropin-releasing factor receptor 1 ligand 3-chloro-4-[8... 7 1
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A ... 1 1
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 0
Dipeptidyl peptidase 4 inhibitor Aminomethylpyrimidine 1ck family 6 3
Histamine H4 receptor ligand 8-chloro-4-[(3R)-3-(methylamino)p... 3 10
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 10
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Vascular endothelial growth factor receptor 2 and Fibroblast g... 5 2
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 3 0
Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threon... 2 1
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Melanin-concentrating hormone receptor 1 and 5-hydroxytryptami... 2 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0760... 4 0
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Translocator protein inhibitor N-butan-2-yl-4-(2-chlorophenyl)... 14 12
Transient receptor potential cation channel subfamily V member... 4 0
Mitogen-activated protein kinase 14 inhibitor pyrimido-pyrimid... 15 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Dipeptidyl peptidase 4 inhibitor (4R,5R)-5-amino-1-[6-(3-methy... 2 5
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Histamine H4 receptor and Histamine H3 receptor ligand 7-cyclo... 2 0
Cytochrome P450 3A4 and Cytochrome P450 2C8 inhibitor N-[3-[(1... 1 0
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 7 7
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 14 14
Dihydrofolate reductase inhibitor 5-[4-[(3,4-dichlorophenyl)me... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 0
Adenosine kinase inhibitor SureCN8248615 family 2 3
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Histamine H4 receptor and Histamine H1 receptor ligand 6-chlor... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Nitric oxide synthase, brain and Nitric oxide synthase, induci... 2 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand (1S,5S)... 1 0
Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... 7 2
Dihydrofolate reductase inhibitor 5-[(7-chloro-10-methylsulfan... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
P2Y purinoceptor 14 inhibitor AGN-PC-0A9S8H family 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 2
Corticotropin-releasing factor receptor 1 ligand 5-N,5-N-bis(c... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 0
Serine/threonine-protein kinase Chk1 inhibitor N'-(8-chloro-3-... 1 1
1-acyl-sn-glycerol-3-phosphate acyltransferase beta inhibitor ... 3 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand 4-N-[... 16 21


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00292975 DNC012174 Investigative Drug 6-Chloro-2-piperazin-1-yl-quinoline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

46129 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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