CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID356
Family Name Neutrophil elastase Inhibitor Ici 200,355 Family
No. of Seeds 9 No. of Other Members 20
Family Centroid CFAMM00188677 Functional Category Investigative Drug
Superfamily Neutrophil elastase Inhibitor Ici 200,355 Superfamily
Class Class 1552

Cousin Family NamesSeedsMembers
Neutrophil elastase Inhibitor FK-706 Family 8 85
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 3 5
Calpain-1 catalytic subunit inhibitor N-[(2S)-4-[2-[[4-[(4-ace... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00188670 CHEMBL293809 Bioactive ICI-200880
CFAMM00188684 CHEMBL340818 Bioactive 4-N-(4-chlorophenyl)sulfonyl-1-N-[(2S)-3-methyl-1-oxo-1-[(2S)-2-[[(3S)-1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl]carbamoyl]pyrrolidin-1-yl]butan-2-yl]benzene-1,4-dicarboxamide
CFAMM00188669 CHEMBL320942 Bioactive 4-N-(benzenesulfonyl)-1-N-[(2S)-1-[(2S)-2-[[(3S)-5,5-difluoro-2-methyl-4,6-dioxo-6-(2-phenylethylamino)hexan-3-yl]carbamoyl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]benzene-1,4-dicarboxamide
CFAMM00188682 CHEMBL116606 Bioactive 4-N-(4-bromophenyl)sulfonyl-1-N-[(2R)-3-methyl-1-oxo-1-[(2S)-2-[(1,1,1-trifluoro-4-methyl-2-oxopentan-3-yl)carbamoyl]pyrrolidin-1-yl]butan-2-yl]benzene-1,4-dicarboxamide
CFAMM00188673 CHEMBL138869 Bioactive 4-N-(4-chlorophenyl)sulfonyl-1-N-[(2S)-3-methyl-1-oxo-1-[(2S)-2-[(5,5,6,6,6-pentafluoro-2-methyl-4-oxohexan-3-yl)carbamoyl]pyrrolidin-1-yl]butan-2-yl]benzene-1,4-dicarboxamide
CFAMM00188678 DNC000773 Investigative Drug ICI 200,880
CFAMM00188677 DNC000772 Investigative Drug ICI 200,355
CFAMM00188674 DNC004109 Investigative Drug ICI-200355
CFAMM00188687 DNC003718 Investigative Drug ICI-200880

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27648 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543