CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3569
Family Name Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor Ligand 2,3,4,5-tetrahydro-1h-benzo[c]azepine Family
No. of Seeds 3 No. of Other Members 6
Family Centroid CFAMM00293814 Functional Category Investigative Drug with Natural Product
Superfamily Dopamine receptor ligand norcamphene derivative Fencamfamine, Amine oxidase inhibitor Rasagiline Superfamily
Class Class 90

Cousin Family NamesSeedsMembers
Alpha-1B adrenergic receptor ligand phenethylamine derivative ... 12 283
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Adrenergic neuron Inhibitor guanidine isoquinoline analog Debr... 2 44
Voltage-dependent T-type calcium channel subunit alpha-1H liga... 10 397
Extracellular calcium-sensing receptor ligand Cinacalcet Family 2 30
Histamine H1 receptor ligand piperazine derivative Cyclizine F... 16 140
Amine oxidase [flavin-containing] B Inhibitor Phenelzine Family 7 15
Amine oxidase [flavin-containing] B Inhibitor Selegiline Family 6 26
Noradrenergic re-uptake Inhibitor Phentermine Family 2 11
Squalene monooxygenase Inhibitor Naftifine Family 8 32
Noradrenergic re-uptake Inhibitor Protriptyline Family 3 25
Dopamine receptor ligand norcamphene derivative Fencamfamine F... 3 41
Amine oxidase [flavin-containing] B Inhibitor Rasagiline Family 2 11
Muscarinic acetylcholine receptor M3 Ligand Diphemanil Methyls... 22 45
Noradrenergic re-uptake Inhibitor Maprotiline Family 6 33
Serotonin re-uptake Inhibitor Dexfenfluramine Family 6 31
C-X-C chemokine receptor type 4 Ligand AMD-3100 Family 3 6
Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17
5-hydroxytryptamine receptor 2C Ligand Lorcaserin Family 8 38
Renin Inhibitor N-methyl-n-(methylbenzyl)formamide Family 2 17
Dipeptidyl peptidase 4 Inhibitor 1-biphenyl-2-ylmethanamine Fa... 2 23
Beta-secretase 1 Inhibitor 4-(4-fluorobenzyl)piperidine Family 2 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand (-)-3... 15 19
Sphingosine 1-phosphate receptor 1 Ligand [3-(4-nonyl-benzylam... 9 22
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Histamine H3 receptor Ligand 1-[2-(2,4,6-trimethyl-phenyl)-eth... 9 15
Calcium-activated potassium channel subunit alpha-1 Ligand N-m... 2 10
Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphtha... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 1
Amine oxidase [flavin-containing] B Inhibitor Methyl-(1,2,3,4-... 2 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 1
Sodium-dependent dopamine transporter and Sodium-dependent ser... 8 2
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor Sodium... 1 10
Sodium-dependent serotonin transporter and Sodium-dependent no... 9 0
Histamine H3 receptor ligand 2-benzyl-4-[4-(2-pyrrolidin-1-yle... 8 4
Sodium-dependent serotonin transporter and Transporter inhibit... 7 2
Sodium-dependent serotonin transporter and Sodium-dependent do... 1 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00293815 DNC012477 Investigative Drug 1,2,3,4,5,6-Hexahydro-benzo[c]azocine
CFAMM00293814 DNC012476 Investigative Drug 2,3,4,5-Tetrahydro-1H-benzo[c]azepine
CFAMM00293813 DNC012495 Investigative Drug 2,3-Dihydro-1H-isoindole

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48688 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543