CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3583
Family Name Reverse transcriptase Inhibitor PT-109 Family
No. of Seeds 6 No. of Other Members 7
Family Centroid CFAMM00293962 Functional Category Investigative Drug
Superfamily Reverse transcriptase and Macrophage migration inhibitory factor Binder Superfamily
Class Class 88

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Vascular endothelial growth factor Inhibitor PTC299 Family 6 145
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Amg 423 family 7 47
Carbonic anhydrase 2 Inhibitor Cyanamide Family 2 32
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Plasminogen and Tissue-type plasminogen activator Inhibitor N-... 1 5
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand 3-benz... 1 6
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Transient receptor potential cation channel subfamily V member... 2 26
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 2-(4-... 8 25
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 9 24
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Macrophage migration inhibitory factor Inhibitor 1-(2-chloroph... 2 22
Reverse transcriptase Inhibitor PT-102 Family 8 12
Reverse transcriptase Inhibitor PT-113 Family 3 4
Metabotropic glutamate receptor 5 Ligand 5-(2-(3-chlorophenyl)... 2 13
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
Bloom syndrome protein inhibitor SR 57227A family 2 12
Acetylcholine receptor subunit delta ligand Guanidine, N-[(6-c... 2 15
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Corticotropin-releasing factor receptor 1 ligand 3-chloro-4-[8... 7 1
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Cell division cycle 7-related protein kinase and Dual specific... 3 1
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Acetylcholinesterase and Cholinesterase inhibitor 2-amino-6-[3... 1 4
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
P2X purinoceptor 7 inhibitor SureCN1635928 family 4 4
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 2 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 5
D(4) dopamine receptor and D(2) dopamine receptor ligand (E)-1... 1 2
Neuropeptide Y receptor type 5 ligand SureCN4464548 family 17 2
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Reverse transcriptase/RNaseH inhibitor PETT deriv. 13 family 1 0
Reverse transcriptase/RNaseH inhibitor 181305-52-2 family 1 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 1
C-C chemokine receptor type 3 ligand CHEMBL360308 family 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00293964 CHEMBL36930 Bioactive 1-(5-Chloropyridin-2-yl)-3-[2-(2,6-difluorophenyl)ethyl]urea
CFAMM00293953 CHEMBL88840 Bioactive PETT deriv. 3
CFAMM00293952 CHEMBL252963 Bioactive 181305-21-5
CFAMM00293962 DNC012561 Investigative Drug PT-109
CFAMM00293959 DNC012556 Investigative Drug PT-110
CFAMM00293966 DNC012514 Investigative Drug PT-114

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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