CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3584
Family Name Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2-yl)-acetamide Family
No. of Seeds 8 No. of Other Members 13
Family Centroid CFAMM00293986 Functional Category Investigative Drug
Superfamily Melatonin receptor type 1A Ligand N-(2,3-dihydro-1h-phenalen-2-yl)-acetamide Superfamily
Class Class 294

Cousin Family NamesSeedsMembers
Sodium-dependent dopamine transporter inhibitor substituted ph... 22 416
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Alpha-1B adrenergic receptor ligand phenethylamine derivative ... 12 283
5-hydroxytryptamine 2 receptor Ligand tricyclic antidepressant... 29 680
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Extracellular calcium-sensing receptor ligand Cinacalcet Family 2 30
Opioid receptor Ligand Methadone Family 3 39
Sodium channel protein type 5 subunit alpha Ligand Indecainide... 2 41
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Noradrenergic re-uptake Inhibitor Phentermine Family 2 11
Noradrenergic re-uptake Inhibitor Protriptyline Family 3 25
DNA Binder Procarbazine Family 8 358
Dopamine receptor ligand norcamphene derivative Fencamfamine F... 3 41
Noradrenergic re-uptake Inhibitor Maprotiline Family 6 33
Noradrenergic re-uptake Inhibitor Milnacipran Family 7 51
Serotonin re-uptake Inhibitor Dexfenfluramine Family 6 31
Peripheral carotid chemoreceptor Ligand Doxapram Family 4 36
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Glutamate receptor AMPA subtype and Noradrenaline uptake Ligan... 9 17
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 3
Substance-P receptor Ligand Vestipitant Family 14 137
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Reverse transcriptase Inhibitor 3-benzylamino-5-ethyl-6-methyl... 2 24
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Sigma non-opioid intracellular receptor 1 Ligand Dimemorfan Fa... 5 15
Renin Inhibitor N-methyl-n-(methylbenzyl)formamide Family 2 17
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Dipeptidyl peptidase 4 Inhibitor 1-biphenyl-2-ylmethanamine Fa... 2 23
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 3 12
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Histone deacetylase 1 Inhibitor 8-(3-benzoyl-ureido)-octanoic ... 7 13
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(6... 1 12
Adenosine receptor A3 and Glutamate receptor ionotropic, NMDA ... 4 30
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Serine/threonine-protein kinase Chk1 Inhibitor 6-(3-aminopropy... 2 7
Amine oxidase [flavin-containing] A Inhibitor 1-(2-naphthyl)-2... 4 4
Sodium-dependent serotonin transporter Inhibitor 1-(2-(naphtha... 5 2
Sodium-dependent dopamine transporter and Sodium-dependent nor... 28 71
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-2-nap... 3 3
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 6 1
Amine oxidase [flavin-containing] B Inhibitor Methyl-(1,2,3,4-... 2 0
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 17 9
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 4 1
Aminopeptidase N Inhibitor 2-amino-n1-benzyl-n3-hydroxymalonam... 3 4
Aminopeptidase N Inhibitor 2-benzyl-n1-hydroxy-n3-(4-phenylbut... 5 3
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 2 4
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 3 10
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand N-(3-... 1 7
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 2
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 7
Kappa-type opioid receptor ligand 1-[(2S)-2-(pyrrolidin-1-ylme... 4 0
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-2-[... 14 4
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 2
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 3
Survival motor neuron protein inhibitor CHEMBL1323700 family 1 4
Sigma non-opioid intracellular receptor 1 ligand 2-(3-bromophe... 5 1
Cathepsin K inhibitor (1R,2R)-N-(cyanomethyl)-5,5-difluoro-2-[... 6 0
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 2 5
Kinesin-like protein KIF11 and Potassium voltage-gated channel... 4 1
Histamine H3 receptor ligand N-ethyl-3-fluoro-3-[3-fluoro-4-(p... 3 0
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-(cyanomethyl)-... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 1
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
Cannabinoid receptor 2 ligand 1-adamantyl(1,3-dihydroisoindol-... 1 0
5-hydroxytryptamine receptor 1A ligand SureCN8901985 family 1 0
Tryptase alpha/beta-1 and Trypsin-1 inhibitor AGN-PC-074JFM fa... 3 1
Sodium-dependent serotonin transporter and Sodium-dependent do... 2 0
Melanocortin receptor 4 and Melanocortin receptor 3 ligand (2S... 2 0
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Urease inhibitor 1-$l^{1}-selanyl-N,N-dimethyl-N'-[(1S)-1-naph... 1 0
Dipeptidyl peptidase 4 inhibitor (2S,4S)-4-fluoro-1-[2-[[(E)-2... 1 0
Prelamin-A/C inhibitor CHEMBL1353052 family 1 1
DNA polymerase beta and Muscleblind-like protein 1 inhibitor C... 1 0
Arachidonate 5-lipoxygenase inhibitor AGN-PC-075QQO family 1 1
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00293980 CHEMBL338425 Bioactive AGN-PC-075KU2
CFAMM00293969 CHEMBL130319 Bioactive N-(2,3-dihydro-1H-phenalen-1-ylmethyl)acetamide
CFAMM00293976 CHEMBL131602 Bioactive SureCN6632742
CFAMM00293982 CHEMBL2314250 Bioactive N-[(1R,2S)-2-naphthalen-1-ylcyclopropyl]acetamide
CFAMM00293986 DNC012519 Investigative Drug N-(2,3-Dihydro-1H-phenalen-2-yl)-acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

38798 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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