CFam Chemical Families Database
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CFam Family Information

CFAM Family ID CFFID36
Family Name Potassium voltage-gated channel subfamily A member 5 Ligand S-20951 Family
No. of Seeds 34 No. of Other Members 206
Family Centroid CFAMM00175562 Functional Category Investigative Drug
Superfamily Delta-type opioid receptor and Potassium voltage-gated channel subfamily A member 5 Binder Superfamily
Class Class 1365

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
5-hydroxytryptamine receptor 3A Ligand Palonosetron Family 12 403
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Retinoic acid receptor alpha Ligand Tamibarotene Family 5 95
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
DNA Binder Procarbazine Family 8 358
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Serum albumin Inhibitor Ebselen Family 3 62
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Motilin receptor Ligand GSK962040 Family 30 457
Poly [ADP-ribose] polymerase 1 Inhibitor BSI-201 Family 3 16
Substance-K receptor and Substance-P receptor Ligand DNK-333 F... 15 95
Histone deacetylase 1 and Tyrosine-protein kinase JAK2 Inhibit... 2 3
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Dual specificity mitogen-activated protein kinase kinase Inhib... 8 4
K-604 family 4 71
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Pan-DAC Inhibitor AR-42 Family 21 153
Amonafide family 3 35
Intedanib family 7 54
Bavisant family 9 65
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Delta-type opioid receptor Ligand Sb 227122 Family 7 5
C-C chemokine receptor type 5 Ligand Tak-220 Family 8 56
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Poly(ADP-ribose) glycohydrolase Inhibitor N-bis-(3-phenyl-prop... 3 7
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Vasopressin V2 receptor Ligand VP-343 Family 1 0
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-m... 8 37
Fumarate reductase flavoprotein subunit Inhibitor 2-heptyl-4-h... 3 16
Urokinase-type plasminogen activator Inhibitor 6-(n-phenylcarb... 2 11
Bile acid receptor Ligand Fexaramine Family 1 26
Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dion... 10 35
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 9 19
Epidermal growth factor receptor Ligand 5,6-bis-p-tolylamino-i... 2 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 19 88
Potassium voltage-gated channel subfamily A member 5 Ligand N-... 8 32
Integrin beta-3 Inhibitor L-767679 Family 3 6
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Farnesyltransferase beta subunit, putative and Protein farnesy... 6 3
Integrin beta-3 Inhibitor L-750034 Family 7 38
Integrin beta-3 Inhibitor SB-208651 Family 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Fatty acid-binding protein and C-X-C chemokine receptor type 1... 1 6
Poly [ADP-ribose] polymerase 1 Inhibitor 8-amino-6h,11h-indeno... 3 9
Transient receptor potential cation channel subfamily V member... 6 33
Poly [ADP-ribose] polymerase 1 Inhibitor 3-morpholin-4-ylmethy... 1 2
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
3-oxo-5-alpha-steroid 4-dehydrogenase 2 Inhibitor 4-[4-(benzyl... 2 19
Androgen receptor Ligand YM-175735 Family 30 129
Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4... 2 17
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 13
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
C-C chemokine receptor type 8 Ligand N-(4-phenylsulfamoyl-naph... 4 62
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 41 24
Aurora kinase B Inhibitor Hesperadin Family 1 1
Integrin alpha-2 and Integrin beta-3 Inhibitor 3-(3-(carbamoyl... 7 13
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 7 13
D(2) dopamine receptor and D(3) dopamine receptor Ligand ST-19... 5 27
Telomerase reverse transcriptase Inhibitor 2,7-dinitroantraqui... 3 8
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Oxysterols receptor LXR-alpha Ligand 2-(2-phenethylphenyl)isoi... 4 7
Serine/threonine-protein kinase Chk1 Inhibitor 6-(3-aminopropy... 2 7
Transient receptor potential cation channel subfamily V member... 1 5
Beta-secretase 1 Inhibitor GSK-188909 Family 16 11
Progesterone receptor Ligand 3-(3,3-dimethyl-2-oxoindolin-5-yl... 2 10
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Telomerase reverse transcriptase Inhibitor 2,7-bis[2-(piperidi... 6 8
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 12
Cannabinoid receptor 1 Ligand N-(3,3-diphenyl)propyl-2-phenyla... 4 18
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Metabotropic glutamate receptor 5 Ligand N-(3-acetamidophenyl)... 4 20
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Sodium-dependent dopamine transporter and Sodium-dependent nor... 19 28
Histone deacetylase 2 Inhibitor N-(4-amino-4'-bromobiphenyl-3-... 1 1
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
MO15-related protein kinase Pfmrk Inhibitor 2-chloro-n-(o-toly... 6 28
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-3-naphthalen-2... 2 0
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 9 7
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 12 4
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-a... 1 15
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
5-hydroxytryptamine receptor 2A Ligand N-(1-(3-bromobenzyl)pip... 6 10
Voltage-dependent calcium channel gamma-1 subunit Ligand NP-11... 8 9
Metabotropic glutamate receptor 5 Ligand 3-cyano-n-(3-cyanophe... 7 5
Dihydroorotate dehydrogenase Inhibitor N-(4-bromo-2-methylphen... 1 3
Cholecystokinin receptor type A Ligand VL-0494 Family 1 0
Myeloperoxidase Inhibitor 4-aminobenzoic Acid Hydrazide Family 1 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
Substance-P receptor ligand AGN-PC-00FJ8P family 6 10
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
Vasopressin V1a receptor ligand AGN-PC-074VJP family 3 1
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 10
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 6 3
Rho-associated protein kinase 2 inhibitor N-(7-chloro-1-oxo-2H... 13 42
Substance-K receptor ligand 4-(4-methylphenyl)-N-[1-[[(2S)-5-[... 6 0
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [2... 2 4
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEDE family 7 17
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZFJZ family 1 3
Substance-K receptor and Substance-P receptor ligand N-[4-[[4-... 1 4
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 1 0
Vasopressin V1a receptor ligand AGN-PC-074VSA family 3 0
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 4 8
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 15 24
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
C-C chemokine receptor type 5 ligand AC1L9USC family 3 2
Progesterone receptor and Androgen receptor ligand AGN-PC-080P... 4 27
Integrin beta-3 and Integrin alpha-IIb inhibitor 2-[7-[[4-(N'-... 7 15
Disintegrin and metalloproteinase domain-containing protein 17... 1 2
Cathepsin K and Cathepsin B inhibitor AGN-PC-01Z23J family 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 7 5
C-C chemokine receptor type 3 ligand 4-[(3-acetylphenyl)carbam... 3 4
C-C chemokine receptor type 3 ligand SureCN6704607 family 3 22
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 4
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7345980... 4 6
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 5
Acetylcholinesterase inhibitor CHEMBL1651130 family 2 3
Vasopressin V2 receptor ligand [2-chloro-4-(prop-2-enylamino)p... 3 14
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 7 1
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 10 0
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 53
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 3 0
Acetylcholinesterase inhibitor 5-benzoyl-2-[2-(1-benzylpiperid... 2 3
Acetylcholinesterase inhibitor 2-[2-(1-benzylpiperidin-4-yl)et... 2 9
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 3 0
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 6 5
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 5
Sigma non-opioid intracellular receptor 1 ligand 2-(2-nitrophe... 2 5
Hypoxia-inducible factor 1-alpha and Ubiquitin carboxyl-termin... 1 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 4
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
D(3) dopamine receptor and Alpha-1B adrenergic receptor ligand... 11 8
Prelamin-A/C inhibitor CHEMBL1547148 family 1 8
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
Cellular tumor antigen p53 and Inositol monophosphatase 1 inhi... 1 12
Cellular tumor antigen p53 inhibitor CHEMBL1554992 family 1 0
Prelamin-A/C and Lysine-specific demethylase 4E inhibitor 4-(4... 2 3
D(2) dopamine receptor and D(3) dopamine receptor ligand 1,1-d... 2 7
Coagulation factor X and Trypsin-1 inhibitor SureCN6161266 family 2 28
Cannabinoid receptor 2 ligand 4-methyl-3-piperidin-1-ylsulfony... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 5 2
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 8 1
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 1 0
Amyloid beta A4 protein inhibitor AGN-PC-08WTQK family 1 3
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 1
Neuromedin-K receptor ligand SureCN2477089 family 2 4
Free fatty acid receptor 1 ligand AGN-PC-03ZC6J family 2 14
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 24 11
Vasopressin V2 receptor and Vasopressin V1a receptor ligand 2-... 6 9
Melanin-concentrating hormone receptor 1 ligand 1-[2-[4-(3-cya... 3 2
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 6
Ribosyldihydronicotinamide dehydrogenase [quinone] and Melaton... 1 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 3
Mitogen-activated protein kinase 14 and Cytochrome P450 2C9 in... 2 0
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Mitogen-activated protein kinase 14 inhibitor 4-chloro-N-cyclo... 2 0
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... 4 0
Gonadotropin-releasing hormone receptor ligand 3-[(2R)-2-amino... 9 21
Dipeptidyl peptidase 8 inhibitor (2S)-2-amino-4-[4-[bis(4-fluo... 2 9
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 8 1
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-3-... 2 0
Kappa-type opioid receptor ligand N-methyl-N-[(1S)-2-pyrrolidi... 3 17
B1 bradykinin receptor ligand 4-(4-methyl-1-oxophthalazin-2-yl... 5 27
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
C-C chemokine receptor type 3 and Sodium-dependent serotonin t... 12 2
Delta-type opioid receptor and Potassium voltage-gated channel... 3 2
Transient receptor potential cation channel subfamily V member... 9 38
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
Neuronal acetylcholine receptor subunit alpha-7 ligand 2,7-bis... 2 1
Neuronal acetylcholine receptor subunit alpha-7 ligand 2,7-bis... 3 2
Histamine H3 receptor ligand SureCN3058680 family 4 0
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Transient receptor potential cation channel subfamily V member... 1 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
C-C chemokine receptor type 2 ligand N-[2-[[(2S,3S)-1-[(2,4-di... 13 8
C-C chemokine receptor type 2 ligand N-[3-amino-5-(trifluorome... 4 1
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Bifunctional epoxide hydrolase 2 inhibitor 1-(3-acetylphenyl)-... 1 3
Sphingosine 1-phosphate receptor 1 ligand 7-(2-hydroxyethyl)-1... 2 10
Substance-P receptor and Potassium voltage-gated channel subfa... 5 0
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4796979 f... 5 4
D(2) dopamine receptor and Potassium voltage-gated channel sub... 1 1
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 2 17
Testosterone 17-beta-dehydrogenase 3 inhibitor AGN-PC-00CHN2 f... 3 2
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 2
Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthy... 2 0
Melanin-concentrating hormone receptor 1 ligand SureCN13655018... 6 23
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
Melanin-concentrating hormone receptor 1 ligand AGN-PC-0762XZ ... 3 1
Melanin-concentrating hormone receptor 1 ligand methyl 4-[(1S,... 1 0
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(cyanomethyl)-... 1 6
ALK tyrosine kinase receptor ligand 4-fluoro-N-[6-(piperidin-1... 10 7
Mitogen-activated protein kinase 14 inhibitor N-[3-[(11-oxo-5,... 2 0
C-C chemokine receptor type 3 ligand 1-(3-acetylphenyl)-3-[3-[... 9 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
P2X purinoceptor 7 inhibitor AGN-PC-050YNC family 1 6
P2X purinoceptor 7 inhibitor SureCN3652462 family 5 2
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 2
Inosine-5'-monophosphate dehydrogenase 2 inhibitor SureCN32339... 2 2
Bifunctional epoxide hydrolase 2 inhibitor 6-[[1-(2,4-dimethyl... 1 3
Mitogen-activated protein kinase 14 inhibitor ethyl 2-[[3-(2,4... 4 0
Mitogen-activated protein kinase 14 inhibitor ethyl 3-(2,4-dif... 5 1
Mitogen-activated protein kinase 14 inhibitor 3-(3-benzamido-4... 2 0
Mitogen-activated protein kinase 14 inhibitor 3-(2,4-difluoroa... 6 0
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 1
Cannabinoid receptor 2 ligand 1-adamantyl-(5-fluoro-2,3-dihydr... 4 7
Transient receptor potential M8 protein ligand 2-(4-bromopheny... 1 0
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Histone deacetylase 1 inhibitor SureCN3642893 family 10 23
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
Tankyrase-2 inhibitor 3-chloro-N-(2-methoxyethyl)-4-(4-methyl-... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 1
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Sodium channel protein type 9 subunit alpha ligand tert-butyl ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand Su... 1 1
Coagulation factor X inhibitor N-(4-chlorophenyl)-2-[[4-(2-oxo... 2 0
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 1 0
5-hydroxytryptamine receptor 7 ligand 2-[4-[4-(2-oxo-1,3,4,5-t... 1 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Chitin synthase 1 inhibitor AC1O53V7 family 9 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 7 12
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
Growth hormone secretagogue receptor type 1 ligand SureCN77944... 1 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 4 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Tryptase alpha/beta-1 and Tryptase delta inhibitor SureCN75047... 4 2
Mitogen-activated protein kinase 14 inhibitor 5-(2-chloro-4-fl... 3 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 1
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 3 0
Protease and Replicase polyprotein 1a inhibitor AC1LALLS family 1 0
C-C chemokine receptor type 3 ligand AGN-PC-075BAT family 1 0
Beta-secretase 1 and Beta-secretase 2 inhibitor AC1N6ZLA family 1 0
Dipeptidyl peptidase 4 inhibitor 4-[[(3S,5S)-5-[(2S)-2-cyanopy... 4 12
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-07... 1 1
Vascular endothelial growth factor receptor 2 ligand isoindoli... 1 0
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 1 0
Coagulation factor X and Tissue factor inhibitor AGN-PC-02WN8Y... 7 22
Urotensin-2 receptor and Kappa-type opioid receptor ligand Sur... 2 0
Somatostatin receptor type 1 ligand AGN-PC-078XL6 family 9 9
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
Transient receptor potential cation channel subfamily V member... 1 1
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Muscarinic acetylcholine receptor M3 ligand N-[[4-fluoro-3-[3-... 3 0
Vascular endothelial growth factor receptor 2 ligand SureCN578... 1 2
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
Collagenase 3 and Interstitial collagenase inhibitor (2R,3S)-N... 1 0
Mitogen-activated protein kinase 14 and Serine/threonine-prote... 1 1
Neuropeptide Y receptor type 5 ligand AGN-PC-01NS0Z family 1 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZK family 3 0
5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-pi... 13 5
D(1A) dopamine receptor and D(3) dopamine receptor ligand 1-[4... 1 0
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-[2-(1-hydroxy-3... 3 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 3 2
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Cannabinoid receptor 1 ligand SureCN14463736 family 2 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 4 0
C-C chemokine receptor type 5 ligand AC1MHP8Y family 1 0
Glucagon receptor and Adenylate cyclase type 1 ligand AGN-PC-0... 1 0
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Fatty-acid amide hydrolase 1 inhibitor [(E)-1-[3-(3-carbamoylp... 1 0
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 4 6
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 1 3
Tyrosine-protein kinase ITK/TSK and Mast/stem cell growth fact... 1 0
Glucose-dependent insulinotropic receptor ligand AGN-PC-04UO8L... 2 2
DNA polymerase III PolC-type inhibitor SureCN3471150 family 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[[1... 2 5
Beta-secretase 1 inhibitor Naphthyl Compound, 5f family 2 0
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide de... 2 4
C-C chemokine receptor type 3 ligand 4-[[2-(4-chlorophenyl)eth... 4 2
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047568... 1 1
Coagulation factor X and Coagulation factor VII inhibitor AGN-... 1 2
Histone deacetylase 1 inhibitor 2-[4-[(2-aminophenyl)carbamoyl... 1 1
Protein farnesyltransferase subunit beta and Protein farnesylt... 2 4
Protein farnesyltransferase subunit beta and Protein farnesylt... 4 13
Progesterone receptor ligand AGN-PC-048NI9 family 1 5
Histone deacetylase 6 and Histone deacetylase 1 inhibitor AGN-... 1 2
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-04XL6C family 2 0
Cyclin-dependent kinase 4 inhibitor SureCN3569974 family 1 0
Serine/threonine-protein kinase Chk1 inhibitor 6-oxo-9-(2-oxo-... 1 0
Acyl-CoA:cholesterol acyltransferase inhibitor N-[2,6-di(propa... 1 2
Telomerase reverse transcriptase inhibitor AGN-PC-07ZBGW family 2 0
Proteinase-activated receptor 1 ligand 2-bromo-N-[3-(butanoyla... 4 0
Metabotropic glutamate receptor 2 ligand 4-[4-(methylamino)phe... 1 4
Arachidonate 5-lipoxygenase inhibitor (Z)-3-(N-hydroxyanilino)... 2 0
Progesterone receptor ligand AGN-PC-00PB7N family 2 1
Acenes Metabolite C.I. Pigment Red 149 Family 1 0
NP (1r,5r)-n-((s)-1-((3-chlorophenyl)amino)-1-oxo-3-phenylprop... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00175628 CHEMBL394793 Bioactive SureCN5516005
CFAMM00175610 CHEMBL2316472 Bioactive 3-(2,4-difluoroanilino)-N-(2-fluoroethyl)-11-oxo-5,6-dihydrodibenzo[3,1-[7]annulene-9-carboxamide
CFAMM00175490 CHEMBL253226 Bioactive SureCN3645712
CFAMM00175679 CHEMBL429464 Bioactive SureCN5510038
CFAMM00175475 CHEMBL1818901 Bioactive 4-(4-fluorophenyl)-N-[6-(pyrrolidin-1-ylmethyl)-7,8-dihydronaphthalen-2-yl]benzamide
CFAMM00175671 CHEMBL1818795 Bioactive 4-(4-chlorophenyl)-N-[6-[(dimethylamino)methyl]-7,8-dihydronaphthalen-2-yl]benzamide
CFAMM00175565 CHEMBL1818797 Bioactive 4-(4-chlorophenyl)-N-[6-(diethylaminomethyl)-7,8-dihydronaphthalen-2-yl]benzamide
CFAMM00175654 CHEMBL217358 Bioactive 3-[[(4R,5S)-5-amino-4-(3,4,5-trifluorophenyl)cyclohexene-1-carbonyl]amino]benzamide;2,2,2-trifluoroacetic acid
CFAMM00175538 CHEMBL2316194 Bioactive 3-(2,4-difluoroanilino)-N-[2-(4-methylpiperazin-1-yl)ethyl]-11-oxo-5,6-dihydrodibenzo[3,1-[7]annulene-9-carboxamide
CFAMM00175592 CHEMBL2316481 Bioactive 3-(2,4-difluoroanilino)-N-[2-(dimethylamino)ethyl]-11-oxo-5,6-dihydrodibenzo[3,1-[7]annulene-9-carboxamide
CFAMM00175641 CHEMBL2316470 Bioactive 3-(2,4-difluoroanilino)-N-methyl-11-oxo-5,6-dihydrodibenzo[3,1-[7]annulene-9-carboxamide
CFAMM00175495 CHEMBL1818783 Bioactive 4-(4-chlorophenyl)-N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]benzamide
CFAMM00175479 CHEMBL398617 Bioactive SureCN3639302
CFAMM00175689 CHEMBL1939737 Bioactive 4-[(R)-[3-(cyclopropanecarbonylamino)phenyl]-[4-[(4-fluorophenyl)methyl]piperazin-1-yl]methyl]-N,N-diethylbenzamide
CFAMM00175571 CHEMBL1818810 Bioactive 4-(4-methylphenyl)-N-[6-(pyrrolidin-1-ylmethyl)-7,8-dihydronaphthalen-2-yl]benzamide
CFAMM00175605 CHEMBL305375 Bioactive AGN-PC-074DHJ
CFAMM00175562 DNC001256 Investigative Drug S-20951

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22645 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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