CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibitor Indirubin-3'-monoxime Family
No. of Seeds 16 No. of Other Members 0
Family Centroid CFAMM00188801 Functional Category Investigative Drug
Superfamily Reverse transcriptase and Receptor-type tyrosine-protein kinase FLT3 Binder Superfamily
Class Class 952

Cousin Family NamesSeedsMembers
Receptor-type tyrosine-protein kinase FLT3 inhibitor indoline ... 4 151
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Fibroblast growth factor receptor 1 and Aurora kinase B Inhibi... 4 51
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
Cyclin-dependent kinase 5 Inhibitor 9-nitropaullone Family 2 13
Platelet-derived growth factor receptor alpha and Platelet-der... 3 3
Serine/threonine-protein kinase Chk1 Inhibitor BIS-IMIDE A Family 1 3


External ID

Functional Category

Molecule Name

CFAMM00188799 DNC007559 Investigative Drug 7-chloroindirubin-3-oxime
CFAMM00188788 DNC010747 Investigative Drug 5-nitroindirubin-3'-oxime
CFAMM00188794 DNC010749 Investigative Drug (2'Z,3'E)-5-Chloro-5'-methyl-indirubin-3'-oxime
CFAMM00188797 DNC007555 Investigative Drug indirubin-3-acetoxime
CFAMM00188786 DNC007561 Investigative Drug 7-bromoindirubin-3-acetoxime
CFAMM00188793 DNC010748 Investigative Drug (2'Z,3'E)-5-Fluoro-5'-methyl-indirubin-3'-oxime
CFAMM00188796 DNC007556 Investigative Drug 7-fluoroindirubin-3-oxime
CFAMM00188785 DNC007560 Investigative Drug 7-bromoindirubin-3-oxime
CFAMM00188792 DNC010741 Investigative Drug (2'Z,3'E)-5-Nitro-5'-fluoro-indirubin-3'-oxime
CFAMM00188795 DNC007557 Investigative Drug 7-iodoindirubin-3-oxime
CFAMM00188802 DNC010625 Investigative Drug (2'Z,3'E)-7-Azaindirubin-3'-oxime
CFAMM00188791 DNC010743 Investigative Drug (2'Z,3'E)-5-Fluoro-5'-fluoro-indirubin-3'-oxime
CFAMM00188801 DNC000796 Investigative Drug Indirubin-3'-monoxime
CFAMM00188790 DNC010742 Investigative Drug (2'Z,3'E)-5-Chloro-5'-fluoro-indirubin-3'-oxime
CFAMM00188800 DNC007558 Investigative Drug 7-fluoroindirubin-3-acetoxime
CFAMM00188789 DNC010744 Investigative Drug (2'Z,3'E)-5-Nitro-5'-methyl-indirubin-3'-oxime

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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