CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3600
Family Name Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor Ligand Siramesine Family
No. of Seeds 18 No. of Other Members 17
Family Centroid CFAMM00294404 Functional Category Investigative Drug
Superfamily D(2) dopamine receptor and D(1B) dopamine receptor Binder Superfamily
Class Class 2748

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Phospholipase A2 Inhibitor Quinacrine Family 13 95
Histamine H1 receptor Ligand Doxylamine Family 2 91
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
5-hydroxytryptamine receptor Ligand Metergolin Family 2 11
DNA Binder Elliptinium Acetate Family 11 116
Nicotinic acetylcholine receptor Ligand AZD0328 Family 11 97
Calcitonin gene-related peptide 1 Inhibitor Cizolirtine Family 3 15
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor Lig... 9 115
Apricoxib family 8 77
Grt 6005/06 family 4 22
PF-02545920 family 16 140
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Alpha-1A adrenergic receptor Ligand RS-17053 Family 9 6
D(2) dopamine receptor Ligand SLV-314 Family 19 69
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 4 35
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
DNA-dependent protein kinase catalytic subunit Inhibitor 2-(1h... 2 0
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
D(1B) dopamine receptor and D(2) dopamine receptor Ligand Flut... 1 6
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Metabotropic glutamate receptor 5 Ligand 7-(3,5-dimethoxypheny... 2 7
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Progesterone receptor and Glucocorticoid receptor ligand (5Z)-... 5 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Protein kinase C theta type and Protein kinase C delta type in... 16 8
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 7 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 6
5-hydroxytryptamine receptor 6 ligand N-[3-[[(2R)-1-methylpyrr... 6 0
Sigma non-opioid intracellular receptor 1 ligand 1'-butyl-6-me... 23 0
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 5 40
Progesterone receptor and Glucocorticoid receptor ligand SureC... 4 2
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 2 1
Melanin-concentrating hormone receptor 1 ligand SureCN11425142... 3 5
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
5-hydroxytryptamine receptor 1D ligand SureCN7253308 family 2 0
5-hydroxytryptamine receptor 2C and Cytochrome P450 1A2 ligand... 6 4
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Glucocorticoid receptor ligand SureCN5650626 family 17 25
Glucocorticoid receptor and Androgen receptor ligand AGN-PC-0A... 3 0
Glucocorticoid receptor ligand AGN-PC-0A9RHA family 1 2
5-hydroxytryptamine receptor 6 ligand SureCN5498885 family 5 4
Sodium/glucose cotransporter 2 inhibitor SureCN1405451 family 4 12
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Sigma non-opioid intracellular receptor 1 ligand 1-benzyl-1'-p... 1 0
Melanin-concentrating hormone receptor 1 ligand 4-[(2-fluoroph... 3 0
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Sodium-dependent serotonin transporter inhibitor AGN-PC-075G9A... 3 2
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Renin and Potassium voltage-gated channel subfamily H member 2... 13 11
Melanin-concentrating hormone receptor 2 ligand (2R)-1'-(9H-ca... 2 10
CGMP-dependent protein kinase inhibitor AGN-PC-075XJ0 family 9 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Transporter and Sodium-dependent serotonin transporter inhibit... 2 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 2A ligand (3R,4R)-3-(2-phenyl-1H-... 1 18
Histamine H3 receptor and Sodium-dependent serotonin transport... 3 2
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 1 2
CGMP-dependent protein kinase inhibitor methyl 2-[[4-[5-(4-flu... 6 1
Thromboxane-A synthase and Thromboxane A2 receptor ligand (Z)-... 2 10
Sigma non-opioid intracellular receptor 1 ligand 1'-[4-[1-(4-f... 2 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand RU-2... 3 4
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 0
5-hydroxytryptamine receptor 1D ligand AGN-PC-01NTBS family 1 1
CGMP-dependent protein kinase inhibitor AGN-PC-0761UG family 1 2
Protein kinase C theta type and Protein kinase C delta type in... 10 7
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
Sigma non-opioid intracellular receptor 1 ligand SureCN7438180... 2 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 1
Sodium/glucose cotransporter 2 inhibitor (2S,3R,4R,5S,6R)-2-[5... 1 2
D(2) dopamine receptor and D(3) dopamine receptor ligand methy... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00294397 CHEMBL63999 Bioactive AGN-PC-00FHEZ
CFAMM00294410 CHEMBL60099 Bioactive SureCN7437057
CFAMM00294416 CHEMBL59852 Bioactive SureCN7440500
CFAMM00294396 CHEMBL304232 Bioactive SureCN7441920
CFAMM00294388 CHEMBL64844 Bioactive 1'-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]spiro[3,4-dihydroisochromene-1,4'-piperidine]
CFAMM00294402 CHEMBL299284 Bioactive SureCN7438773
CFAMM00294387 CHEMBL60608 Bioactive 1'-[4-[1-(4-fluorophenyl)indol-3-yl]butyl]-7-(trifluoromethyl)spiro[1H-2-benzofuran-3,4'-piperidine]
CFAMM00294422 CHEMBL64683 Bioactive SureCN7435844
CFAMM00294406 CHEMBL59249 Bioactive SureCN7429285
CFAMM00294421 CHEMBL64115 Bioactive SureCN7437081
CFAMM00294412 CHEMBL263271 Bioactive SureCN7436300
CFAMM00294399 CHEMBL60845 Bioactive 1'-[3-[1-(4-fluorophenyl)indol-3-yl]propyl]spiro[1H-2-benzofuran-3,4'-piperidine]
CFAMM00294419 CHEMBL62300 Bioactive SureCN7435075
CFAMM00294398 CHEMBL61343 Bioactive 1'-[[1-(4-fluorophenyl)indol-3-yl]methyl]spiro[1H-2-benzofuran-3,4'-piperidine]
CFAMM00294411 CHEMBL59273 Bioactive SureCN7444068
CFAMM00294418 CHEMBL64113 Bioactive SureCN7434839
CFAMM00294404 DNC012651 Investigative Drug Siramesine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26224 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543