CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3612
Family Name Aldose reductase Inhibitor (4-methyl-2-oxo-2h-quinolin-1-yl)-acetic Acid Family
No. of Seeds 1 No. of Other Members 15
Family Centroid CFAMM00294603 Functional Category Investigative Drug
Superfamily Aldose reductase and Tyrosine-protein phosphatase non-receptor type 1 Binder Superfamily
Class Class 1938

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(3) dopamine receptor ligand indol... 4 123
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
Sodium channel Ligand iminostilbene derivative (tricyclic stru... 2 46
Mu-type opioid receptor ligand opiate Remifentanil Family 10 24
Noradrenergic re-uptake inhibitor Dibenzazepine Imipramine Family 8 178
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
Benzodiazepine receptor ligand benzodiazepine derivative Fluni... 2 22
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Motilin receptor Ligand GSK962040 Family 30 457
Tumor necrosis factor Inhibitor Pirfenidone Family 2 38
K-604 family 4 71
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 4-methyl-5,6... 3 12
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Androgen receptor Ligand LG-121071 Family 8 32
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 67
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Transient receptor potential cation channel subfamily V member... 6 33
Acetylcholinesterase Inhibitor Bw-28c51 Family 3 8
Androgen receptor Ligand 6-n-propyl -4-trifluoromethylquinolin... 29 13
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 1 16
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Oxysterols receptor LXR-alpha Ligand 2-(2-phenethylphenyl)isoi... 4 7
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Fatty-acid amide hydrolase 1 Inhibitor 1-biphenyl-4-ylmaleimid... 2 11
Neutrophil elastase Inhibitor 3-butyl-3-ethyl-1-phenylazetidin... 6 5
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 47
Amine oxidase [flavin-containing] B Inhibitor L-136662 Family 3 20
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 5 18
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 9h-bet... 1 1
Glutamate receptor ionotropic, NMDA 2A and Glutamate receptor ... 8 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
Tyrosinase Inhibitor S-2-(o-toluidino)-2-oxoethyl Carbamothioa... 1 1
Leukotriene A-4 hydrolase Inhibitor SA-6541 Family 4 32
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 2 7
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor 8-bromo-4-me... 1 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor AGN-PC-006C4... 1 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 inhibitor SureCN681575... 2 9
Thyroid hormone receptor beta and DNA-(apurinic or apyrimidini... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 1 0
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-cyc... 2 1
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4802053 f... 2 2
Testosterone 17-beta-dehydrogenase 3 inhibitor SureCN4799212 f... 2 2
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 2
P2X purinoceptor 7 inhibitor SureCN3726471 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GOO family 3 0
P2X purinoceptor 7 inhibitor SureCN3721807 family 3 0
Cannabinoid receptor 2 ligand 1-adamantyl-(5-fluoro-2,3-dihydr... 4 7
Angiotensin-converting enzyme inhibitor AGN-PC-076HUL family 1 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 1
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Chitin synthase 1 inhibitor AC1O53V7 family 9 0
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 4 0
Angiotensin-converting enzyme inhibitor 6-methyl-4-(4-methylph... 1 1
Angiotensin-converting enzyme inhibitor 89177-63-9 family 2 0
5-hydroxytryptamine receptor 4 ligand 2-oxo-N-[(1R,5S)-8-(2-pi... 13 5
D(1A) dopamine receptor and D(3) dopamine receptor ligand 1-[4... 1 0
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 3 3
C-C chemokine receptor type 5 ligand AC1MHPA7 family 2 2
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Retinal dehydrogenase 1 and Nuclear receptor ROR-gamma ligand ... 3 13
Aldose reductase and Alcohol dehydrogenase [NADP(+)] inhibitor... 4 0
Angiotensin-converting enzyme inhibitor AGN-PC-076I0I family 1 2
Neuronal acetylcholine receptor subunit beta-2 and Neuronal ac... 1 3
Transient receptor potential cation channel subfamily A member... 1 0
Metabotropic glutamate receptor 2 ligand 4-[4-(methylamino)phe... 1 4
Substance-P receptor ligand AGN-PC-01XQZB family 1 0
NP Tert-butyl ((s)-3-methyl-1-oxo-1-(4-(((s)-1-oxo-1-(p-tolyla... 3 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00294603 DNC012705 Investigative Drug (4-Methyl-2-oxo-2H-quinolin-1-yl)-acetic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24517 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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