CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID362
Family Name 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine receptor 2C Ligand (r,s)-1-(6-fluoro-1h-indol-1-yl)propan-2-amine Family
No. of Seeds 6 No. of Other Members 17
Family Centroid CFAMM00188864 Functional Category Investigative Drug with Human Metabolite & Natural Product
Superfamily 5-hydroxytryptamine receptor 2A and Cholinesterase Binder Superfamily
Class Class 1116

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Neuronal acetylcholine receptor subunit alpha-4 Ligand Varenic... 3 54
Histamine H1 receptor ligand tricyclic antidepressant Deslorat... 6 136
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Acetylcholinesterase Inhibitor Tacrine Family 12 515
D(2) dopamine receptor Ligand Sertindole Family 3 173
Gamma-aminobutyric acid A receptor Ligand Bromazepam Family 2 60
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor Ethion... 5 68
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Prothrombin Inhibitor Ximelegatran Family 8 157
G protein-activated inward rectifier potassium channel 4 Ligan... 3 48
Transient receptor potential cation channel subfamily V member... 15 158
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Neuromedin-K receptor Ligand SB222200 Family 17 235
Substance-P receptor Ligand GSK424887 Family 8 184
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Growth hormone receptor Ligand EP-51216 Family 34 390
D(1B) dopamine receptor Ligand LE-300 Family 65 452
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 23 63
Amg 423 family 7 47
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Lethal factor Inhibitor GM6001 Family 50 435
Cyclin-dependent kinase 5 Inhibitor 9-nitropaullone Family 2 13
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
D(4) dopamine receptor Ligand Fauc 113 Family 14 96
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
TGF-beta receptor type-1 Ligand 4-(3-pyridin-2-yl-1h-pyrazol-4... 3 63
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 3 15
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 19
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 8-(3... 4 22
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 2 11
Histone deacetylase 6 Inhibitor N-(quinolin-3-yl)-6-(sulfamoyl... 4 8
Metabotropic glutamate receptor 5 Ligand 3-(3-pyridin-2-yl-pyr... 4 24
Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 3 11
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Indoleamine 2,3-dioxygenase 1 Inhibitor N-[2-(indol-3-yl)ethyl... 2 2
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand 1-(4-... 10 48
Trypsin Inhibitor 1-benzyl-1h-indole-5-carboxamidine Family 4 3
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 6
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 4 33
5-hydroxytryptamine receptor 2C Ligand Cyclo[(6-bromotryptopha... 3 17
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Hepatocyte growth factor receptor Ligand 1-benzyl-1h-pyrrolo[3... 2 16
Indoleamine 2,3-dioxygenase 1 Inhibitor 4-(1h-1,2,3-triazol-5-... 3 12
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Kinesin-like protein KIF11 Inhibitor 2-(trifluoromethyl)-9h-ca... 5 0
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
Translocator protein Inhibitor 5-phenyl-6-thia-10b-aza-benzo[e... 1 2
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 6
Metabotropic glutamate receptor 5 Ligand 5-(2-methylquinolin-7... 4 3
Metabotropic glutamate receptor 5 Ligand 7-m-tolyl-1,6-naphthy... 4 2
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Metabotropic glutamate receptor 1 Ligand N-(2-phenylpropyl)qui... 3 1
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 1 0
Metabotropic glutamate receptor 1 Ligand (e)-4,4-dimethyl-1-qu... 2 2
Acetylcholinesterase Inhibitor Infractopicrin Family 1 1
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Histone deacetylase Inhibitor ST-5732 Family 8 6
Protein kinase C alpha type Inhibitor Dequalinium Analogue Family 1 10
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 2 1 2
Histamine H3 receptor and Potassium voltage-gated channel subf... 4 33
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 14
5-hydroxytryptamine receptor 6 ligand CHEMBL1950756 family 8 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 4 5
Progesterone receptor and Androgen receptor ligand 5-[4-[(Z)-C... 2 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 2 3
Sodium-dependent serotonin transporter inhibitor SureCN6087392... 1 1
Sodium-dependent serotonin transporter inhibitor SureCN6087152... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 2
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
5-hydroxytryptamine receptor 2A and Alpha-1B adrenergic recept... 10 9
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 1
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Progesterone receptor and Mineralocorticoid receptor ligand AG... 6 1
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 5 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 0
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Sigma non-opioid intracellular receptor 1 ligand SureCN7434677... 1 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
CGMP-dependent protein kinase inhibitor AGN-PC-075XJ0 family 9 1
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 3 0
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 2 0
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 4
D(4) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 1
Prostaglandin D2 receptor 2 ligand SureCN317401 family 3 8
5-hydroxytryptamine receptor 6 ligand 2-methyl-5-methylsulfany... 1 1
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 2 2
5-hydroxytryptamine receptor 6 ligand 5-[3-(2-aminoethyl)indol... 1 0
Prostaglandin D2 receptor 2 ligand 2-[3-[(E)-2-cyano-3-(N-meth... 9 9
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
CGMP-dependent protein kinase inhibitor methyl 2-[[4-[5-(4-flu... 6 1
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 1 0
5-hydroxytryptamine receptor 1D ligand AGN-PC-01NTBS family 1 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
D(3) dopamine receptor and D(4) dopamine receptor ligand (7S)-... 1 2
CGMP-dependent protein kinase inhibitor AGN-PC-075INU family 1 1
Sigma non-opioid intracellular receptor 1 ligand 1-phenyl-4-(2... 1 0
CGMP-dependent protein kinase inhibitor 2-[[4-[5-(4-fluorophen... 1 0
5-hydroxytryptamine receptor 7 ligand 6-bromo-1-[2-[4-(cyclopr... 2 4
Serine/threonine-protein kinase B-raf and Mitogen-activated pr... 16 5
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1
Thromboxane-A synthase inhibitor AGN-PC-07BYVF family 1 0
Thymidylate synthase inhibitor AGN-PC-00EUGY family 2 7
Sodium-dependent noradrenaline transporter and Sodium-dependen... 5 7
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 1
Histamine H3 receptor ligand AGN-PC-09M6FC family 1 9
Nuclear receptor ROR-gamma and Prelamin-A/C ligand CHEMBL14461... 1 18
Cytochrome P450 2C19 inhibitor CHEMBL1449918 family 1 0
Farnesyl pyrophosphate synthase inhibitor [[(5-benzylpyridin-3... 1 0
Lactoylglutathione lyase inhibitor 1-hydroxy-6-[1-(3-methoxypr... 1 0
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 1 4
Kinesin-like protein KIF11 inhibitor AGN-PC-077SFB family 1 0
Pyridines and Derivatives Metabolite (S)-Actinidine Family 1 0
Indoles Metabolite Ethyl 3-methyl-9H-carbazole-9-carboxylate F... 1 1
NP Agn-pc-099dao Family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00188851 CHEMBL80226 Bioactive SureCN8959602
CFAMM00188849 DNC011049 Investigative Drug (R,S)-1-(5-fluoro-1H-indol-1-yl)propan-2-amine
CFAMM00188865 DNC011045 Investigative Drug (S)-1-(5,6-difluoro-1H-indol-1-yl)propan-2-amine
CFAMM00188855 DNC004323 Investigative Drug (2-Indol-1-yl-ethyl)-dimethyl-amine
CFAMM00188864 DNC011046 Investigative Drug (R,S)-1-(6-fluoro-1H-indol-1-yl)propan-2-amine
CFAMM00188861 DNC000798 Investigative Drug Indole N -acetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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