CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFID3624
Family Name cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-specific 3',5'-cyclic phosphodiesterase 4B Inhibitor RS-14491 Family
No. of Seeds 5 No. of Other Members 22
Family Centroid CFAMM00294725 Functional Category Investigative Drug
Superfamily D(4) dopamine receptor and cAMP-specific 3',5'-cyclic phosphodiesterase 4B Binder Superfamily
Class Class 1532

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
Histamine H1 receptor ligand tricyclic antidepressant Loratadi... 5 163
5-hydroxytryptamine receptor 3A Ligand Granisetron Family 26 212
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Histidine decarboxylase Inhibitor Bf-derm1 Family 12 95
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Poly [ADP-ribose] polymerase 1 Inhibitor MK-4827 Family 8 43
Interleukin-1 beta and Interleukin-6 Inhibitor Ibudilast Family 2 11
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Substance-P receptor Ligand TAK-637 Family 18 63
ABC294640 family 5 75
Vascular endothelial growth factor receptor 1 and Angiopoietin... 29 127
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Stress kinase p38 Inhibitor P38 Map Kinase Inhibitor Family 1 3
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Inhibitor of nuclear factor kappa-B kinase subunit epsilon and... 1 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... 3 11
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 1 10
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 3 59
Melanocortin receptor 4 and Melanocortin receptor 3 ligand N-[... 1 0
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 11
5-hydroxytryptamine receptor 2A ligand AGN-PC-04RTMN family 7 5
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M8RE fa... 6 1
B1 bradykinin receptor ligand ELN-441958 family 1 0
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family 2 5
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Dihydroorotate dehydrogenase (quinone), mitochondrial inhibito... 2 21
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Glucocorticoid receptor ligand N-ethyl-2-fluoro-N-[3,3,3-trifl... 16 7
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 1
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Cannabinoid receptor 1 ligand N-[1-[[(1R)-1-[4-(3-chloroindazo... 10 0
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 1
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Histamine H3 receptor ligand N-methyl-N-[(3R)-1-propan-2-ylpyr... 3 1
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 2-... 3 0
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6
Rho-associated protein kinase 2 and Rho-associated protein kin... 2 6
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 5 4
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Lysosomal Pro-X carboxypeptidase inhibitor [(3S,4R)-1-tert-but... 20 13
Lysosomal Pro-X carboxypeptidase inhibitor [(1R,2R,4S)-4-amino... 9 0
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 8 1
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... 6 5
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 1
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... 5 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor AGN-... 1 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor Sure... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor AGN-... 1 0
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 17 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Cannabinoid receptor 1 ligand AGN-PC-07R6QU family 4 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 2
D(4) dopamine receptor and D(1A) dopamine receptor ligand 3-[[... 1 0
Cannabinoid receptor 1 ligand AGN-PC-07NHJ5 family 9 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 17
Vasopressin V2 receptor and Vasopressin V1a receptor ligand (2... 1 0
D(3) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 2 0
NADPH oxidase 4 inhibitor 4-[[benzyl(methyl)amino]methyl]-2-(2... 1 4
Metabotropic glutamate receptor 5 ligand [2-[6-(3-chlorophenyl... 1 2
NADPH oxidase 4 and NADPH oxidase 1 inhibitor 2-(2-chloropheny... 2 5
Kinesin-like protein KIF11 inhibitor SureCN5863107 family 4 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A inhibitor 6-(3... 1 3
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 4 0
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 7 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00294745 CHEMBL1957804 Bioactive (6-chloropyrazolo[1,5-a]pyridin-3-yl)-[4-[2-(2,4-difluorophenyl)ethyl]piperazin-1-yl]methanone
CFAMM00294726 CHEMBL2146809 Bioactive 8-[(4-chlorophenyl)methyl]-6-[[(2R)-1-methylpyrrolidin-2-yl]methyl]pyrido[2,3-d]pyridazin-5-one
CFAMM00294730 CHEMBL2146810 Bioactive 6-[[(2R)-1-butylpyrrolidin-2-yl]methyl]-8-[(4-chlorophenyl)methyl]pyrido[2,3-d]pyridazin-5-one
CFAMM00294725 DNC012750 Investigative Drug RS-14491

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24530 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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